DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and Mcm5

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	675	Identity:	211/675 - (31%)
Similarity:	340/675 - (50%)	Gaps:	77/675 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGE-----IKYTRPAASLESPDRCTLEVSFEDVEKY 65
            |:.||.| |.::    |:.|::||.:::...:     .||........:.....:||..||:..:
Mouse    21 AEEGQAR-KSQL----QRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASF 80

  Fly    66 DQNLATAIIEEYYHIYPF----LCQSVSNYVKDRI------GLKTQKDCYVAFTEVPTRHKVRDL 120
            |:.||     ::.|..|.    |.:..:..|.|.:      |.:..:|..|......:...:|.|
Mouse    81 DEELA-----DHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRIL 140

  Fly   121 TTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQ---FKFTNPTICR-----NP 177
            .:..:..|::|.|.::....|..:.......|..|...:.|:..:   ..:..|..|.     .|
Mouse   141 KSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPRKCNMDQAGRP 205

  Fly   178 VCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTL 242
            .|.....|::. :|...:|||.:::||....:|.|.:||.:::.....|.:.|..|:|
Mouse   206 KCPLDPYFIMP-DKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNR------- 262

  Fly   243 IVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDL 307
            :.:..:..:...|.        .|.:|.|.|    .:|:|....|:..:......:...|.|:..
Mouse   263 VTIMGIYSIKKFGL--------NPSKGRDRV----GVGIRSSYIRVLGIQVDTDGSGRSFAGSVS 315

  Fly   308 PMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTT 372
            |..|   |:.::            ::...|:|:.:..|:.|||:|..::|:.|....|||..|..
Mouse   316 PQEE---EEFRR------------LAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRL 365

  Fly   373 TEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIE 437
            .:..:.|||||:.::|||.|||||.||.|...||..:|||||.||||||||:|:||..|.:|::|
Mouse   366 PDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIME 430

  Fly   438 AGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRY 502
            .||::|||.|:.||||||||.:.|:|||||||||||||||:||:..|||:|.|:|||||.:.||:
Mouse   431 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRW 495

  Fly   503 DRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNI---EESVERAYTREEV 564
            |.:|. :.||.....|:||||:.||:.||.||..|..:|:.::.||.:.   .::||......::
Mouse   496 DETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAVEGEIDLAKM 559

  Fly   565 LRYVTFAR-QFKPVISQEAGHMLVENY----GHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMA 624
            .:::.:.| :..|.:|.||...|...|    ...||.:..:..||:..|||||||:::|::||::
Mouse   560 KKFIAYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALS 624

  Fly   625 KLECSNRVLERHVKEAFRLLNKSII 649
            |::......|..|:||.||...|.:
Mouse   625 KMKLQPFATEADVEEALRLFQVSTL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	20/98 (20%)
		MCM	113..649	CDD:214631	185/551 (34%)
		MCM6_C	702..816	CDD:375690
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	20/99 (20%)
		MCM	133..649	CDD:214631	185/551 (34%)
		Arginine finger	512..515		2/2 (100%)
		BREX_BrxC	<618..>730	CDD:380283	11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820