DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and Mcm4

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_032591.3	Gene:	Mcm4 / 17217	MGIID:	103199	Length:	862	Species:	Mus musculus

Alignment Length:	797	Identity:	246/797 - (30%)
Similarity:	376/797 - (47%)	Gaps:	131/797 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FQDFLEEF-----KEDGEI-------KYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEY 77
            ||.||:.|     ||:..:       .|.:....:.......|.|:.|.::.:.:||...:|...
Mouse   165 FQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNLYRQLISYP 229

  Fly    78 YHIYPFLCQSVSNYVKDRI---------------GLKTQKDCYVAFTEVPTRHKVRDLTTSKIGT 127
            ..:.|....:|:....||.               .|||:              .:|:|....|..
Mouse   230 QEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTK--------------SMRNLNPEDIDQ 280

  Fly   128 LIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKS 192
            ||.|||.|:||..:.||:....|.|..|....|....:.:...|..|.:  |.......|...:|
Mouse   281 LITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEIDRGRIAEPCSCVH--CHTTHSMALIHNRS 343

  Fly   193 LFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTR 257
            .|.|.|.|::||:..::|.|..|..:.:...::||:.||.|||.:.||....||     ..|..|
Mouse   344 FFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAVP-----IRVNPR 403

  Fly   258 AENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMT 322
            ..|            |..:....:..::||        :....|..|.|       .|..:|..:
Mouse   404 VSN------------VKSVYKTHIDVIHYR--------KTDAKRLHGLD-------EEAEQKLFS 441

  Fly   323 DAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAK--TTTEKTSLRGDINVC 385
            :.....:.|:|:..::|:.|.|:|.||||.::::|:|||||.|||..|  :.|.:...|.:||:.
Mouse   442 EKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINIL 506

  Fly   386 IVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICC 450
            :.|||.|:|||.|:.|.:..||..|||||.|||.||||.|::|.|:...|::.|||:|:||||||
Mouse   507 LCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICC 571

  Fly   451 IDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLS 515
            |||||||::..:..:||.|||||:|||:||:...||||||:|||||||..:::..|:..:||||.
Mouse   572 IDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLP 636

  Fly   516 APIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLR-YVTFARQ-FKPVI 578
            ..::|||||.|:::|..:|..|..:|..:|.|:...||.||..:....||: |:.:|.. ..|.:
Mouse   637 HTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTIMPRL 701

  Fly   579 SQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRL 643
            |:||...|:|.|.::|:  .|:| |.......|||||:|||:||.||:..||:|....|:||.||
Mouse   702 SEEASQALIEAYVNMRK--IGSS-RGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAIDVEEAKRL 763

  Fly   644 LNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKFTLSF 708
            ..:::           .....|...||. ||.:              :.|..|...:|:|
Mouse   764 HREAL-----------KQSATDPRTGIV-DISI--------------LTTGMSATSRKRK----- 797

  Fly   709 EDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDELISRKNLIEKLID 773
            |:.......|:|.          :|....:|        .:|:.:.|..:.:....|::.|:.:.
Mouse   798 EELAEALRKLILS----------KGKTPALK--------YQQLFEDIRGQSDTAITKDMFEEALR 844

  Fly   774 RLIYHDQVIIPLKTSTL 790
            .|...|.:.:..||..|
Mouse   845 ALADDDFLTVTGKTVRL 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	21/110 (19%)
		MCM	113..649	CDD:214631	202/539 (37%)
		MCM6_C	702..816	CDD:375690	15/89 (17%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..121
		MCM_N	165..286	CDD:291233	27/134 (20%)
		MCM	266..769	CDD:214631	204/564 (36%)
		P-loop_NTPase	504..643	CDD:304359	76/138 (55%)
		Arginine finger	641..644		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820