DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and Mcm3

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_032589.1	Gene:	Mcm3 / 17215	MGIID:	101845	Length:	812	Species:	Mus musculus

Alignment Length:	749	Identity:	221/749 - (29%)
Similarity:	365/749 - (48%)	Gaps:	120/749 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKDEVGIR-AQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEE 76
            |.|:|.:| ||:.:.|||::.::.|  .|......|.|.::..|.||..|:.:.::..|..::..
Mouse     6 VLDDVELREAQRDYLDFLDDEEDQG--IYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNN 68

  Fly    77 YYHIYPFLCQSVSNYVK--DRIGLKTQKDCYVAFT-EVPTRH-KVRDLTTSKIGTLIRISGQVVR 137
            .:.......:::.::|.  |....|..::.|:... ...::| ..|.||:..:..::.:.|.|.:
Mouse    69 AFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTK 133

  Fly   138 THPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCS-----NRKRFMLDVE--KSLFL 195
            ...|.|::|..|..   |....:.:|:::.... |:...|..|     :.:...|:.|  .|::.
Mouse   134 CSLVRPKVVRSVHY---CPATKKTIERRYSDLT-TLVAFPSSSVYPTKDEENNPLETEYGLSVYK 194

  Fly   196 DFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAEN 260
            |.|.|.|||...:.|.|.:||:|::||..:||:.|:.|||....||...:|
Mouse   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLP-------------- 245

  Fly   261 SSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAE 325
                       |..|....|    .:|...:||:|:.               .::|::...:..:
Mouse   246 -----------GKKGCYTSG----TFRTVLIACNVKQ---------------MSKDIQPAFSADD 280

  Fly   326 WHKIYEMSKDR--NLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVG 388
            ..||.:.||.|  ::::.|..||.|||:|:|.||:.||....|||.:.....:.:|||||:.::|
Mouse   281 IAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIG 345

  Fly   389 DPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDE 453
            |||.||||.|:.|...:||||.|:|:.||..||||||..|:|:.:..:||||::|||.|:.||||
Mouse   346 DPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDE 410

  Fly   454 FDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPI 518
            ||||...|:.||||.|||..::||:||:.|.||||.|:||||||:.||||:.|:..:||.|...:
Mouse   411 FDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL 475

  Fly   519 MSRFDLFFILVDECNEVVDYAIARKIVDLH----------------SNI-------------EES 554
            :|||||.||::|:.:...|..|:..::.:|                |::             ::.
Mouse   476 LSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQ 540

  Fly   555 VERAYTREEVL------------------RYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTS 601
            ..|.|.:.:.|                  :|:..|:..||.::||:...:.|.|..||.:|:.:|
Mouse   541 DTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSS 605

  Fly   602 GRS-TWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLN----KSIIRVEQPDIHLDDD 661
            ..: |..:|.|.||::|||:.|.||...|..|..:..:||..|:.    |.::..|:......:|
Mouse   606 DTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASED 670

  Fly   662 EGLDMDD---GIQHDIDMENNGAAANVDENNGMD 692
            |. |::|   ..|.|.:.:......:..:....|
Mouse   671 ES-DLEDEEEKSQEDTEQKRKRRKTHAKDGESYD 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	16/85 (19%)
		MCM	113..649	CDD:214631	191/597 (32%)
		MCM6_C	702..816	CDD:375690
Mcm3	NP_032589.1	MCM_N	17..129	CDD:291233	20/113 (18%)
		MCM	109..654	CDD:214631	190/592 (32%)
		P-loop_NTPase	340..479	CDD:304359	76/138 (55%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..744		7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810