Protein Alignment Mcm6 and Mcm3

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_032589.1
• Gene: Mcm3 / 17215
• MGIID: 101845
• Length: 812
• Species: Mus musculus
• Alignment Length: 749
• Identity: 221/749 - (29%)
• Similarity: 365/749 - (48%)
• Gaps: 120/749 - (16%)

  Fly    13 VKDEVGIR-AQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEE 76
            |.|:|.:| ||:.:.|||::.::.|  .|......|.|.::..|.||..|:.:.::..|..::..
Mouse     6 VLDDVELREAQRDYLDFLDDEEDQG--IYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNN 68

  Fly    77 YYHIYPFLCQSVSNYVK--DRIGLKTQKDCYVAFT-EVPTRH-KVRDLTTSKIGTLIRISGQVVR 137
            .:.......:::.::|.  |....|..::.|:... ...::| ..|.||:..:..::.:.|.|.:
Mouse    69 AFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTK 133

  Fly   138 THPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCS-----NRKRFMLDVE--KSLFL 195
            ...|.|::|..|..   |....:.:|:::.... |:...|..|     :.:...|:.|  .|::.
Mouse   134 CSLVRPKVVRSVHY---CPATKKTIERRYSDLT-TLVAFPSSSVYPTKDEENNPLETEYGLSVYK 194

  Fly   196 DFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAEN 260
            |.|.|.|||...:.|.|.:||:|::||..:||:.|:.|||....||...:|
Mouse   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLP-------------- 245

  Fly   261 SSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAE 325
                       |..|....|    .:|...:||:|:.               .::|::...:..:
Mouse   246 -----------GKKGCYTSG----TFRTVLIACNVKQ---------------MSKDIQPAFSADD 280

  Fly   326 WHKIYEMSKDR--NLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVG 388
            ..||.:.||.|  ::::.|..||.|||:|:|.||:.||....|||.:.....:.:|||||:.::|
Mouse   281 IAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIG 345

  Fly   389 DPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDE 453
            |||.||||.|:.|...:||||.|:|:.||..||||||..|:|:.:..:||||::|||.|:.||||
Mouse   346 DPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDE 410

  Fly   454 FDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPI 518
            ||||...|:.||||.|||..::||:||:.|.||||.|:||||||:.||||:.|:..:||.|...:
Mouse   411 FDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL 475

  Fly   519 MSRFDLFFILVDECNEVVDYAIARKIVDLH----------------SNI-------------EES 554
            :|||||.||::|:.:...|..|:..::.:|                |::             ::.
Mouse   476 LSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQ 540

  Fly   555 VERAYTREEVL------------------RYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTS 601
            ..|.|.:.:.|                  :|:..|:..||.::||:...:.|.|..||.:|:.:|
Mouse   541 DTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSS 605

  Fly   602 GRS-TWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLN----KSIIRVEQPDIHLDDD 661
            ..: |..:|.|.||::|||:.|.||...|..|..:..:||..|:.    |.::..|:......:|
Mouse   606 DTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASED 670

  Fly   662 EGLDMDD---GIQHDIDMENNGAAANVDENNGMD 692
            |. |::|   ..|.|.:.:......:..:....|
Mouse   671 ES-DLEDEEEKSQEDTEQKRKRRKTHAKDGESYD 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	17/88 (19%)
		MCM	113..649	CDD:475121	191/597 (32%)
		MCM6_C	702..816	CDD:465688
Mcm3	NP_032589.1	MCM_N	16..104	CDD:464206	17/89 (19%)
		MCM	109..654	CDD:214631	190/592 (32%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..744		7/41 (17%)