DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and mcm-4

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_490962.1	Gene:	mcm-4 / 171793	WormBaseID:	WBGene00003156	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	829	Identity:	254/829 - (30%)
Similarity:	402/829 - (48%)	Gaps:	142/829 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DAQVGQLR-VKDEV------------GIR-----AQKLFQDFLEEFK-----ED----------- 35
            |.:..|:| ::||:            |.|     .|:.|:|||..||     ||
Worm    83 DHRTVQIRGMEDEMAGDDGQPRLYVWGTRICVADVQRSFRDFLTTFKISQLAEDENMMTGHDEAL 147

  Fly    36 GEIKYTRP---AASLESPDR--CTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDR 95
            .||....|   ...||..|.  ..:.::.:.:..:.:.|...:|.....:.|:|...|:....:|
Worm   148 HEIDVNHPYYMERLLECNDAEVTHINLNLKHLNAFSEALYRKVIAYPADVIPYLDIVVNEVFAER 212

  Fly    96 IGLKTQKDCYV-AFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEI 159
            ......:...: .|....||: :|.|..:.:..||.|||.|.||..:.||:.||.|.|..|...|
Worm   213 FNRTLAQSIELRPFNAQKTRN-MRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAFGI 276

  Fly   160 RNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRS 224
            .:...:.:...|.:|.|  |||...|.|...:|:|||.|.:::||:..::|.|..|..|.:....
Worm   277 ESEVDKGRIEEPVVCTN--CSNTHCFQLVHNRSVFLDKQVVKLQESPDDMPSGETPHTVSVYAHG 339

  Fly   225 ELVETVQAGDRYDFTGT-----LIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMREL 284
            .|||:||.|||...||.     :.|.|....||.|..                 |.:.||..|::
Worm   340 SLVESVQPGDRITVTGIFRATGMKVNPKQRALASVYR-----------------TSIDALHFRKM 387

  Fly   285 NYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPS 349
            :             |:|.           .:|..:.:|:....:|.|:||..::...|..|:.||
Worm   388 D-------------TSRL-----------HQDNGETITEERIQQIIELSKRPDIMDALAQSIAPS 428

  Fly   350 IYGNDEVKRGILLQQFGGVAK--TTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTS 412
            ||.:|:||||:|...|||..|  .||.||.||.:||:.:.|||.|:|||.|:.|....||:.|||
Worm   429 IYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTS 493

  Fly   413 GKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIA 477
            ||.|||.||||:|.||.::...|::.|||:|||||:|||||||||::..:..:||.|||||:|||
Worm   494 GKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIA 558

  Fly   478 RAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIAR 542
            :||:...||||.|:||||||::.:::|:|::.:||.|...::|||||.|::||..:|:.|..:..
Worm   559 KAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGN 623

  Fly   543 KIVDLHSNIEESVERA-YTREEVLR-YVTFAR-QFKPVISQEAGHMLVENYGHLRQRDTGTSGRS 604
            .:|.|:...:.:.|:. :....:|| |:.:|: ...|.:|:||...::|.|..:|:     :|..
Worm   624 HLVSLYFENDGNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMRK-----AGAQ 683

  Fly   605 TWRITV--RQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMD 667
            ..:||.  |||||:||||||.||:..|..|....|::||.|..:::           ....:|..
Worm   684 HGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREAL-----------KQSAVDPS 737

  Fly   668 DGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLH-MRAEEARCEV 731
            .| :.|:.:..:|.:|:  ....::......:::.|....|     :::..:.| :::.:..|:.
Worm   738 TG-RVDVAILASGMSAS--GRKAVEAMCEAVLKQLKTAKGF-----VTSKALFHTLKSADKTCQR 794

  Fly   732 EGNDTGIKRSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQ 780
            |..|..|..                     :|:|..|.:..||:.:..:
Worm   795 EVFDEAINE---------------------LSKKESIARSGDRIRFQTE 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	20/105 (19%)
		MCM	113..649	CDD:214631	208/547 (38%)
		MCM6_C	702..816	CDD:375690	12/80 (15%)
mcm-4	NP_490962.1	MCM_N	121..226	CDD:317013	20/104 (19%)
mcm-4	NP_490962.1	MCM_OB	230..730	CDD:330264	208/559 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820