Protein Alignment Mcm6 and MCMDC2

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_775789.3
• Gene: MCMDC2 / 157777
• HGNCID: 26368
• Length: 681
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 147/757 - (19%)
• Similarity: 263/757 - (34%)
• Gaps: 247/757 - (32%)

  Fly    29 LEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVK 93
            |::|.:|  .||...:....:..|..:.::..||.:.|..|...|:.:     |.....|
Human    20 LQKFIDD--CKYYNDSKQSYAVYRFKILINPSDVVELDAELGNHILHQ-----PLKAAEV----- 72

  Fly    94 DRIGLKTQKDCYVAFTEVPTRHKVRDL-TTSKIGTLIRISGQVVRTHPVHPELVS-GVFMC---L 153
                  .|..|::|   |.|...:..| |.::|..::::      ||  .|.|.| |:.:|   |
Human    73 ------FQSVCFIA---VKTLSLIGQLQTETQINIVLKL------TH--LPPLPSYGLDLCEFPL 120

  Fly   154 D--------------CQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQE 204
            |              ..|.|....|..:|    :|.:..|...|            .||.||:.
Human   121 DYTSQRFYMMQGIVIAMTTITKYTQGARF----LCSDEACPLSK------------GFQYIRVH- 168

  Fly   205 TQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLI-----------VVPDVSVLAGVGTRA 258
                     :|.|.|           .|..|.||...|.           |:.|..::..:.|:|
Human   169 ---------VPGATE-----------SATIRNDFLCNLCASSLQEDRKFRVLGDKQIVEIIATKA 213

  Fly   259 ----ENSSRHKPGEGMDGVTGLKALGMRELN----YRMAFL---------ACSVQATTARFGGTD 306
                :..|.::|.........|:...:.::|    |::..:         |..::|.:..|..:.
Human   214 LRAFQGYSNNQPFRFQSLTIFLRDESVNKMNIGNEYKIIGIPTCVKTSQTAVCIEANSITFCNSK 278

  Fly   307 LPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKT 371
            :|............:|.:...|...:.  .|::.:.|:.  |..|  :.:|..:|:    .:.:|
Human   279 VPSGISDNFRCLLSLTSSSCWKFTAIL--ANIFASQITP--PGTY--NLLKLCLLM----SLVQT 333

  Fly   372 TTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFS----PRAI----------------YTSGKAS 416
            |.....|...:::.|:    |:.:..:.::.:||    ||.|                |.:|..|
Human   334 TDRNKELEDCLDILII----TSDTLLIDRLLNFSINLVPRGIRHLVSTEIFPTLSRNKYGTGAVS 394

  Fly   417 SAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEF-----DKMDQRDQVAIHEAMEQQTISI 476
                               |:||:.:||..|||.|.:.     ||::|     :...:|.::|::
Human   395 -------------------IQAGSALLAKGGICFIGDLASHKKDKLEQ-----LQTVLESRSITV 435

  Fly   477 ARAGVR--------ATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFI------ 527
            ...|.:        .|...:.|..:..       |...|.::|.|....::.:.|...|
Human   436 YIPGKKFGEDIDQQMTFPVQCSFWSFV-------DVDSSSRRNAQKINTLIGQMDCSLIPANLVE 493

  Fly   528 ---LVDECNE---------VVDYAIARKIVDLHSNIE---ESVERAYTREEVLRYVTFARQFKPV 577
               |:..|||         .|.:.:.:.|     |.|   .:..|.:|.|:..:.:.||:.....
Human   494 AFGLLINCNESSPCHPFLPTVQHTLNKAI-----NPEGLFYAASRQFTTEDFEKLLAFAKNLNVE 553

  Fly   578 ISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEA-- 640
            .|.||..|....|...|:..||:...|  :::...|:.::.||||.|:|...|:||:..|..|
Human   554 FSLEAERMTHGYYLASRRIRTGSVCGS--KLSASALKYLVFLSEAHARLNLRNKVLKEDVLIAAL 616

  Fly   641 ------------------------FRLLNKSIIRVEQPDIHL 658
                                    |.|.|:..:  ||.|::|
Human   617 LFETSLTLKYGATVFCVAPNAVFPFELYNEEYL--EQRDLYL 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	16/79 (20%)
		MCM	113..649	CDD:475121	126/662 (19%)
		MCM6_C	702..816	CDD:465688
MCMDC2	NP_775789.3	MCM	<390..621	CDD:475121	59/268 (22%)