DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and MCMDC2

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_775789.3	Gene:	MCMDC2 / 157777	HGNCID:	26368	Length:	681	Species:	Homo sapiens

Alignment Length:	763	Identity:	146/763 - (19%)
Similarity:	263/763 - (34%)	Gaps:	259/763 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVK 93
            |::|.:|  .||...:....:..|..:.::..||.:.|..|...|:.:     |.....|
Human    20 LQKFIDD--CKYYNDSKQSYAVYRFKILINPSDVVELDAELGNHILHQ-----PLKAAEV----- 72

  Fly    94 DRIGLKTQKDCYVAFTEVPTRHKVRDL-TTSKIGTLIRISGQVVRTHPVHPELVS-GVFMC---L 153
                  .|..|::|   |.|...:..| |.::|..::::      ||  .|.|.| |:.:|   |
Human    73 ------FQSVCFIA---VKTLSLIGQLQTETQINIVLKL------TH--LPPLPSYGLDLCEFPL 120

  Fly   154 D--------------CQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQE 204
            |              ..|.|....|..:|    :|.:..|...|            .||.||:.
Human   121 DYTSQRFYMMQGIVIAMTTITKYTQGARF----LCSDEACPLSK------------GFQYIRVH- 168

  Fly   205 TQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLI-----------VVPDVSVLAGVGTRA 258
                     :|.|.|           .|..|.||...|.           |:.|..::..:.|:|
Human   169 ---------VPGATE-----------SATIRNDFLCNLCASSLQEDRKFRVLGDKQIVEIIATKA 213

  Fly   259 ----ENSSRHKPGEGMDGVTGLKALGMRELN----YRMAFL---------ACSVQATTARFGGTD 306
                :..|.::|.........|:...:.::|    |::..:         |..::|.:..|..:.
Human   214 LRAFQGYSNNQPFRFQSLTIFLRDESVNKMNIGNEYKIIGIPTCVKTSQTAVCIEANSITFCNSK 278

  Fly   307 LPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLF------PSIYGNDEVKRGILLQQF 365
            :|............:|.:...|          :..:::::|      |..|  :.:|..:|:
Human   279 VPSGISDNFRCLLSLTSSSCWK----------FTAILANIFASQITPPGTY--NLLKLCLLM--- 328

  Fly   366 GGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFS----PRAI----------------Y 410
             .:.:||.....|...:::.|:    |:.:..:.::.:||    ||.|                |
Human   329 -SLVQTTDRNKELEDCLDILII----TSDTLLIDRLLNFSINLVPRGIRHLVSTEIFPTLSRNKY 388

  Fly   411 TSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEF-----DKMDQRDQVAIHEAME 470
            .:|..|                   |:||:.:||..|||.|.:.     ||::|     :...:|
Human   389 GTGAVS-------------------IQAGSALLAKGGICFIGDLASHKKDKLEQ-----LQTVLE 429

  Fly   471 QQTISIARAGVR--------ATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFI 527
            .::|::...|.:        .|...:.|..:..       |...|.::|.|....::.:.|...|
Human   430 SRSITVYIPGKKFGEDIDQQMTFPVQCSFWSFV-------DVDSSSRRNAQKINTLIGQMDCSLI 487

  Fly   528 ---------LVDECNE---------VVDYAIARKIVDLHSNIE---ESVERAYTREEVLRYVTFA 571
                     |:..|||         .|.:.:.:.|     |.|   .:..|.:|.|:..:.:.||
Human   488 PANLVEAFGLLINCNESSPCHPFLPTVQHTLNKAI-----NPEGLFYAASRQFTTEDFEKLLAFA 547

  Fly   572 RQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERH 636
            :......|.||..|....|...|:..||:...|  :::...|:.::.||||.|:|...|:||:..
Human   548 KNLNVEFSLEAERMTHGYYLASRRIRTGSVCGS--KLSASALKYLVFLSEAHARLNLRNKVLKED 610

  Fly   637 VKEA--------------------------FRLLNKSIIRVEQPDIHL 658
            |..|                          |.|.|:..:  ||.|::|
Human   611 VLIAALLFETSLTLKYGATVFCVAPNAVFPFELYNEEYL--EQRDLYL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	16/79 (20%)
		MCM	113..649	CDD:214631	125/668 (19%)
		MCM6_C	702..816	CDD:375690
MCMDC2	NP_775789.3	PTZ00111	<358..>435	CDD:173403	22/100 (22%)
MCMDC2	NP_775789.3	MCM	<514..622	CDD:278895	30/114 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810