Protein Alignment Cdc7 and CDC7

DIOPT Version :10

• Sequence 1: NP_727103.1
• Gene: Cdc7 / 31598
• FlyBaseID: FBgn0028360
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_010267.3
• Gene: CDC7 / 851545
• SGDID: S000002175
• Length: 507
• Species: Saccharomyces cerevisiae
• Alignment Length: 612
• Identity: 150/612 - (24%)
• Similarity: 238/612 - (38%)
• Gaps: 171/612 - (27%)

  Fly   102 TKQARN------KSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTV-----LLGTLRRE--SHLP 153
            |.:.:|      :.:|.:..|...:|.|...:.:..:||.||||:|     :.|.:.::  ||..
Yeast     2 TSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFW 66

  Fly   154 DSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDF 218
            :......|:|....||.|.||..||..:..|.|...|..:....|.......|:|:..|:.|:.|
Yeast    67 NYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTF 131

  Fly   219 YTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARS 283
            |..:.:..|::|:..||.||:.||...:||||:||:|||:|......:|||||||:       ..
Yeast   132 YRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAE-------AQ 189

  Fly   284 SGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPV 348
            ....:.|::.|:.:|..|.|:                   |.|..     ||.||:.  .|....
Yeast   190 MDYKSMISSQNDYDNYANTNH-------------------DGGYS-----MRNHEQF--CPCIMR 228

  Fly   349 NDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQP 413
            |..:|:                                       |..|..|....|........
Yeast   229 NQYSPN---------------------------------------SHNQTPPMVTIQNGKVVHLN 254

  Fly   414 QLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPE 478
            .:..:|.|...|.    |..|.:.                           .|:||||.|:|.||
Yeast   255 NVNGVDLTKGYPK----NETRRIK---------------------------RANRAGTRGFRAPE 288

  Fly   479 VLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMIT 543
            ||:|...|:|.:|:|:.|||.||::...:|.|::.:|..:|.|:.||||.:.:||.| ||
Yeast   289 VLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCA-AL----- 347

  Fly   544 LSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQY-----FFNCLCED---- 599
                 ..|......|.:...:.:|:......|:.::..|.: ....:|     .|..|.::
Yeast   348 -----HGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTI-GTFPEYSVAFETFGFLQQELHDR 406

  Fly   600 ---SDYLTEP------LDAYE--------------CFPPSAYDLLDRLLEINPHKRITAEEALKH 641
               ...|.:|      :||||              ||     .:|::..|::|.||.:||:.||.
Yeast   407 MSIEPQLPDPKTNMDAVDAYELKKYQEEIWSDHYWCF-----QVLEQCFEMDPQKRSSAEDLLKT 466

  Fly   642 PFFTAAEE------AEQTEQDQLANGT 662
            |||....|      .|.|::|.:.:.:
Yeast   467 PFFNELNENTYLLDGESTDEDDVVSSS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	138/557 (25%)
		Protein Kinases, catalytic domain	<474..644	CDD:473864	55/201 (27%)
		Protein Kinases, catalytic domain	<616..675	CDD:473864	16/53 (30%)
CDC7	NP_010267.3	STKc_Cdc7	31..348	CDD:270921	112/430 (26%)
		Protein Kinases, catalytic domain	<443..476	CDD:473864	14/37 (38%)