Protein Alignment Cdc7 and CDC7

DIOPT Version :10

• Sequence 1: NP_727103.1
• Gene: Cdc7 / 31598
• FlyBaseID: FBgn0028360
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_003494.1
• Gene: CDC7 / 8317
• HGNCID: 1745
• Length: 574
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 200/616 - (32%)
• Similarity: 288/616 - (46%)
• Gaps: 113/616 - (18%)

  Fly    74 FATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTF 138
            |...|:.::....|..|.|                 ::.|..|...:|.:..:|.:..:||.|||
Human    22 FQAEGSLKKNEQNFKLAGV-----------------KKDIEKLYEAVPQLSNVFKIEDKIGEGTF 69

  Fly   139 STVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASA 203
            |:|.|.|    :.|......|.|:||.||||||.||..||||:|..||::||:|:..|.|.:...
Human    70 SSVYLAT----AQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHV 130

  Fly   204 AFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLV 268
            ...||::.|:.|.|....:...|:|:||.||..||:.:|:|.::||||||||||||||.:::.||
Human   131 VIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALV 195

  Fly   269 DFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKR 333
            ||||||                           ..:::|....:..:.:.||..........:
Human   196 DFGLAQ---------------------------GTHDTKIELLKFVQSEAQQERCSQNKSHII-- 231

  Fly   334 MRLHEESNKMPLK-PVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQ------QQ 391
                 ..||:||. ||    |.:..:||...::..:|    ....|:|.:|.:..::      .|
Human   232 -----TGNKIPLSGPV----PKELDQQSTTKASVKRP----YTNAQIQIKQGKDGKEGSVGLSVQ 283

  Fly   392 QQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNA------------ 444
            :....::.....|...|.....:|.:..:|....|.......:.:|....|:|
Human   284 RSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPAS 348

  Fly   445 -KCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYP 508
             .|.|:|...||..||.:::..|.||||||:|.||||.|.|:||||:|:|:|||||||::|..||
Human   349 LTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 413

  Fly   509 FFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLK 573
            |:||.:|..|||:|:||.|.:...:.|....:.|..|:.....:|||||.|.|    ..|:...|
Human   414 FYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLR----GMDSSTPK 474

  Fly   574 SYESVDG----------------SCEVCRNCDQYFFNCL-------CED--SDYLTEPLDAYECF 613
            ....:.|                ||.|.....||..|..       ||.  .:|.|. |:.:...
Human   475 LTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTN-LEGWNEV 538

  Fly   614 PPSAYDLLDRLLEINPHKRITAEEALKHPFF 644
            |..||||||:||::||..||||||||.||||
Human   539 PDEAYDLLDKLLDLNPASRITAEEALLHPFF 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	190/563 (34%)
		Protein Kinases, catalytic domain	<474..644	CDD:473864	79/194 (41%)
		Protein Kinases, catalytic domain	<616..675	CDD:473864	22/29 (76%)
CDC7	NP_003494.1	STKc_Cdc7	56..438	CDD:270921	145/427 (34%)
		Protein Kinases, catalytic domain	<293..>419	CDD:473864	48/125 (38%)
		Protein Kinases, catalytic domain	<358..571	CDD:473864	92/217 (42%)