DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc7 and gish

DIOPT Version :9

Sequence 1:	NP_727103.1	Gene:	Cdc7 / 31598	FlyBaseID:	FBgn0028360	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	106/514 - (20%)
Similarity:	177/514 - (34%)	Gaps:	136/514 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 QRLPRQTVQQYATGTPATGSAGRHSGRAFATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSE 110
            ||..||.    :.|.|.|.:||..:|.   .|.||         .|:.|..::.......|....
  Fly     2 QRRERQA----SGGGPQTTTAGPSAGN---VANAT---------TALAGGKSSSNNMYSTRQSVS 50

  Fly   111 EAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLG-TLRRESHLPDSLRRKFAIKHHIPTSHPDRI 174
            .....|:     :|..|.|..:||.|.|..:.|| .|....|:        |||.....|...::
  Fly    51 TTTGVLM-----VGPNFRVGKKIGCGNFGELRLGKNLYNNEHV--------AIKMEPMKSKAPQL 102

  Fly   175 MKELQCMTKMG-----GKENVVGIH----CCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQY 230
            ..|.:....:|     ..:.:..|:    |..||:|....::.....|.|.....:..:..:...
  Fly   103 HLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMI 167

  Fly   231 MRNLLVALRHVHKFDVIHRDVKPSNFLYNR----RRREFLLVDFGLA---------QHVNPPAAR 282
            .:.||..:.:||...:|:|||||.|||..|    |.:...::|||||         :|:.....:
  Fly   168 AKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK 232

  Fly   283 S-SGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAG------LGGAVKRMRLHEES 340
            | :|:|..::.            |:...||:..:.|::.:    |      |.|::....|..::
  Fly   233 SLTGTARYMSI------------NTHMGREQSRRDDLEAL----GHMFMYFLRGSLPWQGLKADT 281

  Fly   341 NKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQP----- 400
            .|...:.:.|...:...|...||                .|::.....:..::....:.|
  Fly   282 LKERYQKIGDTKRATPIEVLCDG----------------HPEEFATYLRYVRRLDFFETPDYDFL 330

  Fly   401 ----QQQSQQQHPQRQPQLAQMDQTASTPSGS---------KYNTNRNVSAAAANNAKCVCFA-- 450
                |....::....:.:.....:|.|||.||         ..|.:|: :..|..|||....|
  Fly   331 RRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRH-NVTAKTNAKGGVAAWP 394

  Fly   451 ---NPSVCLNCLMKKEVH-------------------ASRAGTPGYRPPEVLLKYPDQT 487
               .|...|..|...:.|                   |..:.||..:.|||  :..|:|
  Fly   395 DVPKPGATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEV--EVVDET 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	88/435 (20%)
		PKc_like	<474..644	CDD:304357	5/14 (36%)
		PKc_like	<616..675	CDD:304357
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	63/332 (19%)
		S_TKc	62..335	CDD:214567	62/312 (20%)
		CK1gamma_C	354..428	CDD:289378	17/74 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030