DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc7 and cdc7

DIOPT Version :9

Sequence 1:	NP_727103.1	Gene:	Cdc7 / 31598	FlyBaseID:	FBgn0028360	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005171217.1	Gene:	cdc7 / 492768	ZFINID:	ZDB-GENE-041114-113	Length:	549	Species:	Danio rerio

Alignment Length:	577	Identity:	201/577 - (34%)
Similarity:	291/577 - (50%)	Gaps:	67/577 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RTTKQARNKS------EEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLGTLRRESHLPDSLRR 158
            |:.::.|::.      |..|..|...:|.:.::|.:..:||.||||:|.|.    |:.:.||.||
Zfish    13 RSVEKGRSRHKISRDVETEIAYLYEVLPQLSRIFRIIDKIGEGTFSSVYLA----EAQMTDSSRR 73

  Fly   159 KFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMD 223
            .||:||.||||||.||..||||:|..||.|||:|:..|.|.:.....|||:|.|..|.|....:.
Zfish    74 LFALKHLIPTSHPVRIAAELQCLTVAGGTENVMGVTYCFRKEHHVVIVMPYMEHQTFVDIVGLLS 138

  Fly   224 VPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQH-----------VN 277
            ..::|.|:.:||.||:|:|||.:||||:||:|||:||::||:.||||||||.           |.
Zfish   139 FEDVRHYIYHLLKALKHIHKFGIIHRDIKPTNFLFNRQKREYALVDFGLAQGTPDTQIELLKVVK 203

  Fly   278 PPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKR----MRLHE 338
            ....:..||:..:..:..|........||:.|            |:.:......||    .|:..
Zfish   204 SKGHKGGGSSKMVEESLGKQKLVPLPPNSRNP------------AVQSSTKAPAKRPCPPSRVKH 256

  Fly   339 ESNKMPLKPVNDIAP-SDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQ 402
            ....|.|    |.|| |...|:|::.:|..:|...:.|....:|:            :::..|::
Zfish   257 SKELMGL----DKAPRSVFGEKSINSTNSHKPGSDKVEGLLSKPK------------KEEVIPRK 305

  Fly   403 QSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANN-AKCVCFANPSVCLNCLMKKEVHA 466
            ....:| :..|..|.::|....|:.|     :....||.|. ..|.|:....||..||.:|:..|
Zfish   306 IVSAKH-RSVPVRAPLNQKQKLPAES-----QKPKPAAVNPLLTCNCYMTDRVCNICLSRKQQVA 364

  Fly   467 SRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAI 531
            .||||||:|.||||.|.|:|.||:|:|:||||.||::|..||||||.:|.|||.:|:||.|.:..
Zfish   365 PRAGTPGFRAPEVLTKCPNQGTAIDMWSAGVILLSLLSGRYPFFKANDDLIALTQIMTIRGSKET 429

  Fly   532 RKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNC- 595
            .:.|....:.|..|:....|:||.||...|....:.||.|...:::.....|.....:......
Zfish   430 IEAAKTFGKSIVCSRELPRLDLRILCETLRGLRSWDDASLPAEFQASHNPAEEKEEAESPALKST 494

  Fly   596 ---LCEDSDYLTEPLDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEE 649
               ||..|..|.|  ..::..|...|||||:||::||..||||..||:||.|....|
Zfish   495 GSRLCRSSAELKE--IGWDRVPDEVYDLLDKLLDLNPATRITASTALQHPLFKDMSE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	193/539 (36%)
		PKc_like	<474..644	CDD:304357	69/173 (40%)
		PKc_like	<616..675	CDD:304357	19/34 (56%)
cdc7	XP_005171217.1	STKc_Cdc7	45..431	CDD:270921	157/423 (37%)
cdc7	XP_005171217.1	PKc_like	<332..513	CDD:304357	68/182 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594733
Domainoid	1	1.000	160	1.000	Domainoid score	I4027
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2736
OMA	1	1.010	-	-		QHG60149
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.800