DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc7 and ball

DIOPT Version :9

Sequence 1:	NP_727103.1	Gene:	Cdc7 / 31598	FlyBaseID:	FBgn0028360	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	92/499 - (18%)
Similarity:	155/499 - (31%)	Gaps:	164/499 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RPKTGVPSTNVVYANGGGSWRAAPRQTQRLPRQTVQ----------QYATGTPATGSAGRHSGRA 73
            :||...|:..||.|      :.|..:..::|.:..:          |:..| |:.|..|  .|..
  Fly     6 KPKAAAPAKKVVSA------KKAKSKLYKMPEKVKEGTVFTDLAKGQWRIG-PSIGVGG--FGEI 61

  Fly    74 FATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLF-DVHSRIGNGT 137
            :|.....|:     |..||:              |.|...|         |.|| ::|..:.|..
  Fly    62 YAACKVGEK-----NYDAVV--------------KCEPHGN---------GPLFVEMHFYLRNAK 98

  Fly   138 FSTVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDAS 202
            ...:                ::|..||.:.:.....|:        ..|...|.|       :..
  Fly    99 LEDI----------------KQFMQKHGLKSLGMPYIL--------ANGSVEVNG-------EKH 132

  Fly   203 AAFVMPFMAHD--RFQDFYTRMDVPE--IRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRR- 262
            ...|||....|  :|.: .....:||  :.:....:|...:::|....:|.|:|.:|.|....:
  Fly   133 RFIVMPRYGSDLTKFLE-QNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKG 196

  Fly   263 --REFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDA 325
              .:..|||||||.|              ....:.|.:....:|           |.::..:.||
  Fly   197 GAAQAYLVDFGLASH--------------FVTGDFKPDPKKMHN-----------GTIEYTSRDA 236

  Fly   326 GLGGAVKRMRLH------------------EESNKMPLK--------------PVNDIAPSDAPE 358
            .||...:|..|.                  ::...:|.|              .:..:.|...|.
  Fly   237 HLGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPP 301

  Fly   359 QSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTAS 423
            ...|...:|......||     |...:.:.......:|.:.|.......  :.:||.:. :...|
  Fly   302 PIGDFMKYVSKLTHNQE-----PDYDKCRSWFSSALKQLKIPNNGDLDF--KMKPQTSS-NNNLS 358

  Fly   424 TPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHAS 467
            .|..||        ||.|..||.:    .|..||..:.:::.||
  Fly   359 PPGTSK--------AATARKAKKI----DSPVLNSSLDEKISAS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	69/383 (18%)
		PKc_like	<474..644	CDD:304357
		PKc_like	<616..675	CDD:304357
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	66/384 (17%)
		SPS1	47..432	CDD:223589	83/452 (18%)
		Pol_alpha_B_N	<399..>502	CDD:285602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030