Protein Alignment Cdc7 and hsk1

DIOPT Version :9

• Sequence 1: NP_727103.1
• Gene: Cdc7 / 31598
• FlyBaseID: FBgn0028360
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_596328.1
• Gene: hsk1 / 2541165
• PomBaseID: SPBC776.12c
• Length: 507
• Species: Schizosaccharomyces pombe
• Alignment Length: 663
• Identity: 150/663 - (22%)
• Similarity: 232/663 - (34%)
• Gaps: 271/663 - (40%)

  Fly   107 NKSEEAINDLLTR----IPDIGKLF-------DVHSRIGNGTFSTV----------------LLG 144
            |||:|.|.|:..|    |.:|.:.|       .:..:||.||||:|                :..
pombe    37 NKSQEMIQDIPARDREEIENITRTFVELQENYRLIEKIGEGTFSSVYKAEDLHYGRYINDWDIQS 101

  Fly   145 TLRRES-----HLP---DSLRRKF-AIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYD 200
            .:.:||     .:|   ||.:.|: |||....||.|.||..||:.:..:.|...:..:...:|.:
pombe   102 EVLKESSFGKEKIPVNEDSRKPKYVAIKKIYATSSPARIYNELEILYLLRGSSVIAPLITALRNE 166

  Fly   201 ASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREF 265
            .....|:|:..|..|:.:|:.....::..|.|.|..|::......:||||:||||||::.|.:..
pombe   167 DQVLVVLPYYEHTDFRQYYSTFSYRDMSIYFRCLFQAMQQTQTLGIIHRDIKPSNFLFDVRTKHG 231

  Fly   266 LLVDFGLAQHVN----PPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAG 326
            :|||||||:..:    ..:.|.:.|.||..|.:                        ..||.:..
pombe   232 VLVDFGLAERYDGRQQSHSCRCTNSNAAELAHD------------------------FSIAQETS 272

  Fly   327 LGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQ 391
            | |.:|                ||..||.
pombe   273 L-GYIK----------------NDTRPSK------------------------------------ 284

  Fly   392 QQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCL 456
                                                                             
pombe   285 ----------------------------------------------------------------- 284

  Fly   457 NCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAE 521
                    .|:||||.|:|.||||.|...|:..||:|:||||.||.::..:|.|.:.:|..||.|
pombe   285 --------RANRAGTRGFRAPEVLFKCSSQSPKVDIWSAGVILLSFLTKRFPMFNSKDDVDALME 341

  Fly   522 IVTIFGDQAIRKTALAL------DRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDG 580
            |..|||...:|:.| ||      ..:.||:::.  :|.|||.|                :.|
pombe   342 IACIFGKSEMRQCA-ALHGCTFETNVSTLTEKR--VNFRKLIL----------------WAS--- 384

  Fly   581 SCEVCRNCDQYFFNCLCEDSDYLTEPLDAYECFPPS-----AYDLLDRLLEINPHKRITAEEALK 640
                            |..:....|.|.    ..||     ..|.|::.||::.:|||:|||||.
pombe   385 ----------------CGSASIYKEKLR----HKPSQEERLCLDFLEKCLELDCNKRISAEEALD 429

  Fly   641 HPFF-------------TA-----AEEAEQTEQDQLANGTPRKMRRQRYQSHRTVAASQEQVKQQ 687
            |.|.             ||     .|.:.:.::|..|          ::.||......||:..:.
pombe   430 HDFLYLDNLAYEKKDDDTAFDNSFGETSFEKDEDLTA----------KHLSHILDFKEQEETDEP 484

  Fly   688 VALDLQQAAINKL 700
            .:|..::.:|:::
pombe   485 TSLSKRKRSIDEI 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	129/565 (23%)
		PKc_like	<474..644	CDD:304357	56/180 (31%)
		PKc_like	<616..675	CDD:304357	21/81 (26%)
hsk1	NP_596328.1	STKc_Cdc7	66..433	CDD:270921	128/558 (23%)
		Pkinase	68..433	CDD:278497	128/556 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I1078
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		mtm9301
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	O	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
TreeFam	1	0.960	-	-
	10	9.940