DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and Clmn

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_444385.2	Gene:	Clmn / 94040	MGIID:	2136957	Length:	1052	Species:	Mus musculus

Alignment Length:	946	Identity:	170/946 - (17%)
Similarity:	278/946 - (29%)	Gaps:	307/946 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KNEKHVILCLLE-VARRGAKFGM---------------------LAPMLVQMERQIDREIAADIK 184
            |:::..|..||. |.|:..|:|:                     :.|.||.|::.:
Mouse   184 KDQRKAIKTLLSWVQRKTRKYGVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQAL--------- 239

  Fly   185 ANGAGCSENGTQTDALETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQ--- 246
                   |:.|: |.||...|.|.....|.......|:..|..|.::        ::.|..|
Mouse   240 -------EDSTR-DNLEKAFSIAHDSLHIPRLLEPEDIMVDMPDEQS--------IVTYVAQFLE 288

  Fly   247 --PQIITNDLKSLDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGG 309
              |::...|..:.|:         ..|.:...||:.|.....|...:|:
Mouse   289 RFPELEPEDFVNPDK---------EAPIESTFVRIKESPSEQGSRVLLL---------------- 328

  Fly   310 WDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERSPPAARRVF--- 371
                                                 ..||...:  .|..|.|.|...:||
Mouse   329 -------------------------------------SENGERAY--TVNQETSYPPPDKVFVCD 354

  Fly   372 --NSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTPQRKFLNQQANGGGIA 434
              .||             ||....:.|     .|.||.:|.::       ..:.::|...|
Mouse   355 QLESP-------------TGFCLDSAP-----SHKLSDSSTEF-------MHEIIDQVLQG---- 390

  Fly   435 SATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRLI----DMRKKQS-SLDSYSSGPKSLPGYS 494
             :||.:.::...|....:|.:....|||.|...::.:    |:.|..| |.|.:.|......|..
Mouse   391 -STGKTGSIAEPTPESSILSTRKDGRRSNSLPVKKTVHFEADLHKDASCSKDPFYSSDFRFEGSP 454

  Fly   495 CSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQ- 558
            .:.:|.:...|..|.| .||.....|    ||......|..||...|.:.:|   |..:...||
Mouse   455 KATKELSKQDGHVSLA-EVSKEKKKS----EQEARLVLEAASDKVPESTVDG---LDAVPQDAQP 511

  Fly   559 KRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTD----ILEEEDLNGQDREEDQEDY 619
            .::|.....::|...|........|    ||.|......:|:    :|..|.:       |:|||
Mouse   512 SQDSSFCNGTVESPSSQGEKGPPPS----SPGDHTLLANSTELKVQLLTVEPM-------DKEDY 565

  Fly   620 SVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSP 684
            ..|     :|...|..::....|..:.....:|..:.:..:.|::...|....|....||.||:.
Mouse   566 FEC-----IPLKASKFNRDLVDFASTSQAFGEDPSSHEKTRGEEEGSENHAEKPGKRKSKSPRAE 625

  Fly   685 LAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNS-----------TGAT 738
            ......|..............|:....:..|.....:|..||...:.:::           :|.:
Mouse   626 TEAAESRLEPKKLEPPPKDPEQEDQGHALPPETPADKKPKVYEKAKRKSTRHHSEEEGEAESGFS 690

  Fly   739 TT-----PVAPPRSRQATQLPMVRDVTNTWSGRTTGAP-KRRPPCTA------DTFVAP------ 785
            ..     |.|||.:  :..|..:|      |....|.. |..||.:.      |.|..|
Mouse   691 AVCEEEIPSAPPST--SVSLETLR------SHSEEGLDFKPSPPLSKISVIPHDLFYYPHYEVPL 747

  Fly   786 ------------------TNGTGPAGSFERNGKGRSSQILYDSNGRRVRSGAPGCTSSLTTSPVK 832
                              |:...|..|:.::.:...:    |.:....:|....|:.||   ||.
Mouse   748 AAVLEAYAEGGEDLKSEDTDLEHPEDSYLQDSREEEA----DEDEEEAQSSQSSCSFSL---PVD 805

  Fly   833 NHASSPLAQQLLEAASSAKNDAQILEKMKSLLSRYAAGNQTKAGVGATATAANKINSNGKKTPVY 897
            |...|     :.|..|.....::              |..:..|.|:              .|.:
Mouse   806 NSYPS-----VSEHVSHVDGSSE--------------GPTSALGPGS--------------PPSH 837

  Fly   898 EDFTTAWVHSNGNLERSESCSPP---------------AKARSKRSSAASSCESNNSNAGAGSGA 947
            ||........||.:|..:|..||               |...||:.......:...|:.....|.
Mouse   838 EDHQPKETKENGPVESQQSQEPPNPELPTKPLEEKLTEASTSSKKKEKRKHMDHVESSLFIAPGT 902

  Fly   948 AAGSASVVSPRRERGMSKIPAP---------VRHHT 974
            ...|..:.....|.   |:|:.         :|.||
Mouse   903 VRSSDDLEENSSEH---KVPSRNSHSDSSIYIRRHT 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	6/17 (35%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	7/66 (11%)
Clmn	NP_444385.2	Actin-binding	1..288		25/128 (20%)
		CH	33..134	CDD:278723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..178
		CH	191..286	CDD:278723	22/119 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..420		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..545		24/101 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..727		25/149 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..929		35/213 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900