DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and EPPK1

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_112598.3	Gene:	EPPK1 / 83481	HGNCID:	15577	Length:	5088	Species:	Homo sapiens

Alignment Length:	1083	Identity:	194/1083 - (17%)
Similarity:	327/1083 - (30%)	Gaps:	327/1083 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRQARNKSMTRSMTSGLAGP----ILAMGNVHYLPAAKSGTFFARDNVSNFI--TWCRKSLKIIE 129
            |||.   |.:...|||:.||    .||.|........:      .|:|..::  |.|      |.
Human  3779 RRQV---SASELHTSGILGPETLRDLAQGTKTLQEVTE------MDSVKRYLEGTSC------IA 3828

  Fly   130 CLLFETDDLIMRKNEKHVILCLLEVARRGAKFGMLAP--MLVQMERQ----------------ID 176
            .:|....|...|:.:..:...:.:        |:|.|  .||.:|.|                ::
Human  3829 GVLVPAKDQPGRQEKMSIYQAMWK--------GVLRPGTALVLLEAQAATGFVIDPVRNLRLSVE 3885

  Fly   177 REIAADIKANGAGCSENGTQTDALETGNSSAATMTTITT-TTVETDLYDDSD-----DSETEDDG 235
            ..:||.:.  |....|.....:...||.:...|...|:. ..::.||.....     :::....|
Human  3886 EAVAAGVV--GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 3948

  Fly   236 DQNPVLMYGPQPQIITNDLKSLDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRS 300
            ..:||..:.....:........:||.|.|.:    ||.     .::|.:.....:.|.:|::||.
Human  3949 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD----PSD-----DTKGFFDPNTHENLTYVQLLRR 4004

  Fly   301 HV--------MVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQ 357
            .|        |:::.|....: |.|.:...|..|.           .|.:|......|..:...:
Human  4005 CVPDPDTGLYMLQLAGRGSAV-HQLSEELRCALRD-----------ARVTPGSGALQGQSVSVWE 4057

  Fly   358 VIFERSPPAARRVFNSPNCNGGPGTGSSCG---TGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTP 419
            ::|.|.....||.........|..|....|   |.::..|.........:.||.        |.|
Human  4058 LLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPR--------PDP 4114

  Fly   420 QRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGS-----PSLARRSMSPSPRRLIDMRKKQSS 479
            :.                 :.:..|.:...|:|.|.     ..||...:|.:.|        :..
Human  4115 RE-----------------ALRAATMEVKVGRLRGRAVPVWDVLASGYVSRAAR--------EEL 4154

  Fly   480 LDSYSSGPKSLPG----YSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNG- 539
            |..:.||...||.    .:..:|||....|..........|....|.||...|        |:|
Human  4155 LAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDG--------DSGR 4211

  Fly   540 --SEISDEGYRSLGVIQSGAQKRESLHSQASIEDAE------------------------SNARL 578
              .|...||........:.|.:|:    :.::.||.                        |.||.
Human  4212 SQREGQGEGETQEAAAATAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARR 4272

  Fly   579 DQTSSDSQISPSDEPAEKAT-TDILEEED-------LNGQDREEDQEDYSVCD--GPQSLPAILS 633
            |:..:.........|...|. |.::||.:       ..|..|:....:.....  ||::|..:..
Human  4273 DELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQ 4337

  Fly   634 GAHKLSDKFEQ-------------SGVFIT-------DDEITV-------------DIAKTEDQS 665
            |...|.:..|.             :||.:.       .:::::             .:...|.|:
Human  4338 GTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGHQEKMSIYQAMWKGVLRPGTALVLLEAQA 4402

  Fly   666 VANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGG-AGGSLQD--LSSR---SGLPAPAFSRKQP 724
            ....:.:|..||            |.|::.:...| .||.:|:  ||:.   :|...|...::..
Human  4403 ATGFVIDPVRNL------------RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQIS 4455

  Fly   725 VY--------------RSVRTRNSTGATTTPVAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRP 775
            ::              |.:..:.:||....||  ...|....:...|...:....|....|
Human  4456 LFQAMQKDLIVREHGIRLLEAQIATGGVIDPV--HSHRVPVDVAYRRGYFDEEMNRVLAHP---- 4514

  Fly   776 PCTADTFVAPTNGTGPAGSFERNGKGRSSQILYDSNGRRVRSGAPGCTSSLTTSPVKNHASSPLA 840
              :.||          .|.|:.|.....:.:      :.:|...|...:.|....:....|:  .
Human  4515 --SDDT----------KGFFDPNTHENLTYV------QLLRRCVPDPDTGLYMLQLAGRGSA--V 4559

  Fly   841 QQLLEAASSAKNDAQIL------------------------EKMKSLLSRYAAGNQTKAGVGATA 881
            .||.|....|..||:::                        ::.:.|||||.||..|...:|||.
Human  4560 HQLSEELRCALRDARVMPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATL 4624

  Fly   882 TAANKINSNGKKTPVYEDFTTAWVHSNGNLERSESCSPPAKARSKRSSAASSCESNNSNAGA--- 943
            |:.               ...|...:....| :|:.||....|....:|....:.......|
Human  4625 TSL---------------LAQAQAQARAEAE-AEAGSPRPDPREALRAATMEVKVGRLRGRAVPV 4673

  Fly   944 ----GSGAAAGSASVVSPRRE------RGMSKIPAPVRHHTEL 976
                .||..:|:|     |.|      .|...:||..|..|.:
Human  4674 WDVLASGYVSGAA-----REELLAEFGSGTLDLPALTRRLTAI 4711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	20/93 (22%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	17/74 (23%)
EPPK1	NP_112598.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Plectin 1	34..71
		Interaction with KRT5. /evidence=ECO:0000250\|UniProtKB:Q8R0W0	42..1115
		Plectin	74..113	CDD:307019
		Plectin	151..189	CDD:307019
		Plectin	317..357	CDD:307019
		Plectin	393..433	CDD:307019
		Plectin	604..644	CDD:307019
		Plectin	643..682	CDD:307019
		PLEC	679..716	CDD:197605
		Plectin	718..758	CDD:307019
		Plectin	969..1001	CDD:307019
		PLEC	1000..1036	CDD:197605
		Plectin	1038..1078	CDD:307019
		Plectin 21	1239..1276
		Plectin 22	1277..1314
		Plectin	1278..1317	CDD:307019
		Plectin 23	1315..1352
		Plectin 24	1353..1390
		Plectin	1354..1393	CDD:307019
		Plectin 25	1391..1428
		Plectin 26	1564..1601
		Plectin	1565..1605	CDD:307019
		Interaction with KRT5. /evidence=ECO:0000250\|UniProtKB:Q8R0W0	1572..5085		194/1083 (18%)
		Plectin	1603..1643	CDD:307019
		PLEC	1641..1677	CDD:197605
		Plectin	1679..1718	CDD:307019
		Plectin	1891..1931	CDD:307019
		Plectin	1930..1969	CDD:307019
		Plectin	2005..2045	CDD:307019
		Plectin	2218..2263	CDD:307019
		Plectin	2261..2301	CDD:307019
		PLEC	2299..2335	CDD:197605
		Plectin	2337..2376	CDD:307019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2578..2637
		Plectin	2754..2799	CDD:307019
		Interaction with KRT14. /evidence=ECO:0000250\|UniProtKB:Q8R0W0	2761..2953
		Plectin	2797..2837	CDD:307019
		PLEC	2835..2871	CDD:197605
		Plectin	2873..2912	CDD:307019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3114..3168
		Plectin	3285..3330	CDD:307019
		Plectin	3328..3368	CDD:307019
		PLEC	3366..3402	CDD:197605
		Plectin	3404..3443	CDD:307019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3645..3702
		Plectin	3819..3864	CDD:307019	11/58 (19%)
		Plectin	3862..3902	CDD:307019	7/41 (17%)
		PLEC	3900..3936	CDD:197605	6/35 (17%)
		Plectin	3938..3977	CDD:307019	6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4179..4236		14/68 (21%)
		Plectin	4353..4398	CDD:307019	2/44 (5%)
		Plectin	4396..4436	CDD:307019	11/51 (22%)
		PLEC	4434..4470	CDD:197605	4/35 (11%)
		Plectin	4472..4511	CDD:307019	8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4715..4769
		Plectin	4886..4931	CDD:307019
		Plectin	4929..4969	CDD:307019
		PLEC	4967..5003	CDD:197605
		Plectin	5005..5044	CDD:307019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900