DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pigs and gas2l1

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_701004.4	Gene:	gas2l1 / 572219	ZFINID:	ZDB-GENE-070705-38	Length:	1074	Species:	Danio rerio

Alignment Length:	1095	Identity:	310/1095 - (28%)
Similarity:	445/1095 - (40%)	Gaps:	336/1095 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARPYRPFKSSEEYLEAMREDLAEWLSTLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYLA 70
            ::..||||||||||.||:|||||||:||| :|.|.||.||:.|:||.|||:|||.|.:||.::
Zfish    12 SKSIRPFKSSEEYLYAMKEDLAEWLNTLY-DLDITADTFMEGLETGCALCRHANNVNRAAHEF-- 73

  Fly    71 RRQARNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFET 135
              :|.......|:.......:....||  :|    |:|.|||||||||.|||:.|.|.:.|:|||
Zfish    74 --KANCPDAALSLRIPSKDVVFQSRNV--IP----GSFLARDNVSNFIGWCRQELWIKDVLMFET 130

  Fly   136 DDLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDAL 200
            :||:.|.|||:.:||||||||||||||||||||:|:|.:|:.||..         .||.|:...
Zfish   131 NDLVERCNEKNFVLCLLEVARRGAKFGMLAPMLIQLEEEIEEEIRD---------QENLTEVMG- 185

  Fly   201 ETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLM--YGPQPQIITNDLKSLDEMVRD 263
            |||.|.:....|.|               ..:..|:.:|.|:  :..|.:.:..|:::|||:||:
Zfish   186 ETGESESPPKRTYT---------------RKQSIGEPDPELLARWREQQKRVLLDMRNLDELVRE 235

  Fly   264 LVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRA- 327
            ::.:|:|||||||.:||||||::||:..|||:|:||:|||||||||||||.|||||||||||.|
Zfish   236 ILGQCSCPSQFPMTKVSEGKYKVGDSSALIFIRVLRTHVMVRVGGGWDTLEHYLDKHDPCRCAAY 300

  Fly   328 QHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERSPPAARRVFNSPNCNGGPGTGSSCGTGVVG 392
            .||...|.  ...|:|:...|:                    ..:|.:.:.||...:.      |
Zfish   301 AHRYQQAK--ASGQAPHSKSSS--------------------THSSRSTSPGPHWRNE------G 337

  Fly   393 VAVPPTLQNGHSLSPNSGKYRSRSPT-PQRKFLNQQANGGGIASATGSSQTVTTDTSSGQ---LL 453
            :| |..:.:..||.|..|.....||: |.|              :..::..|..||::|:   ||
Zfish   338 IA-PYKMPDRRSLDPAMGTTAQSSPSRPGR--------------SHHAAVPVEMDTNTGRPTTLL 387

  Fly   454 GSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSA 518
            ..|...|    ..||....:|.|:|          .||....|               |.|..|.
Zfish   388 PRPPRDR----SEPRHFNPLRNKES----------LLPARRLS---------------GDSDSST 423

  Fly   519 GSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGA-------QKRESLHSQASIEDAESNA 576
            .|...|..||                 |..|||...:.|       .::|..|   .||.....|
Zfish   424 ASSKGGSTGG-----------------GRFSLGTRHAHADEVVLLVNRKEGKH---VIERPGGAA 468

  Fly   577 -----RLDQTSSDSQISPSDEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILSGAH 636
                 |..||.:.|  :..:.||::|:| ||:...                  ||.|
Zfish   469 QIPALRTPQTRARS--ASRERPAQQAST-ILKPSP------------------PQGL-------- 504

  Fly   637 KLSDKFEQSGVFITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGA 701
                               .::.:|.......::|...|...:.||| |:|.:.          .
Zfish   505 -------------------AEVHRTPHTERGRSLGPDGPRKLQTPRS-LSQGKT----------P 539

  Fly   702 GGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATTTPVAPPR------SRQATQLPMVRDVT 760
            .|.|.|:|     |..:..||.|...|:..|........|.|.|:      .|||..    ....
Zfish   540 RGRLGDVS-----PGSSPRRKDPHPLSIDRREELRPKHVPTASPKLSGSMPRRQANS----SGSN 595

  Fly   761 NTWSGRTTGAPKR------RPPCTADTFVAPTNGT---------------------------GPA 792
            :...|.|:|:|.:      |||...    :|::|:                           .|.
Zfish   596 SPAKGCTSGSPAKKGMVMPRPPAPR----SPSSGSRKLLPPVTQPGRRSPHSSPRSSHHPPRSPR 656

  Fly   793 GSFERNGKGRSSQILYDSNGRRVRSGAPGCTSSLTTSPVKNHASSPLAQQLL------------E 845
            .:......||..::..:.:.::..|.......||...|    :..|..:|.|            :
Zfish   657 SAHNSRSIGRDQRVWANPHNQQQESQEDSSIFSLHLLP----SLDPQREQDLYRSFEAEFLANTQ 717

  Fly   846 AASSAKNDAQILEKMKSLL---SRYAAG---------NQTKAGVGATATAANKINSNGK------ 892
            .|.:....|....:|:||.   |:.|.|         |.|.:...::.::.:.:|..||
Zfish   718 QAKAGHGKASAGREMRSLQLPGSQQALGVLPNSSGDTNVTDSAYSSSNSSTSSLNVGGKVGVLPD 782

  Fly   893 ---------KTPVYEDFTTAWVHS-------NGNLERSESCSPPAKARSKRSSAASSCESNNSNA 941
                     :|...|| ..|.:||       ||.:...|.....:..|...:.::|..|...||.
Zfish   783 LRESKRTNSRTCALED-PPALLHSQIRGGLTNGGMMEGERWGGRSGLRKLPAISSSIEEGETSNP 846

  Fly   942 GAGSGAAAGSASVVSPRRERG---MSKIP--------------APV---RHHTEL 976
            |.       |.||..|:...|   ::::|              |.|   .||.:|
Zfish   847 GL-------SRSVCHPKDINGSLPLTEVPMESQEELVEWPGLEADVPQCEHHPDL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	69/136 (51%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	48/66 (73%)
gas2l1	XP_701004.4	CH	28..154	CDD:294029	69/136 (51%)
gas2l1	XP_701004.4	GAS2	230..297	CDD:280367	48/66 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573426
Domainoid	1	1.000	127	1.000	Domainoid score	I5330
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2744
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343422at2759
OrthoFinder	1	1.000	-	-		FOG0001647
OrthoInspector	1	1.000	-	-		oto41214
orthoMCL	1	0.900	-	-		OOG6_107791
Panther	1	1.100	-	-	O	PTHR46756
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5836
SonicParanoid	1	1.000	-	-		X3764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790