DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and syne1a

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_021324303.1	Gene:	syne1a / 569553	ZFINID:	ZDB-GENE-030131-4172	Length:	8731	Species:	Danio rerio

Alignment Length:	1048	Identity:	201/1048 - (19%)
Similarity:	350/1048 - (33%)	Gaps:	286/1048 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YRPFKSSEEYLEAMREDLAEWLSTLYPELSINADNFMDR------------LDTGVA-LCKHANY 60
            :.|....:|.:...:..|.||     .:|....:..::|            |...|: |.:||..
Zfish  5507 WSPLSQMQEQIRTHQALLQEW-----QDLQGEFEGLVERVALLGEVVQTEMLHQQVSELSRHAEE 5566

  Fly    61 VRQAAVDYLARRQARNKSMTR-------------SMTSGLAGPILAMGNVHYLPAAKSGTFFARD 112
            ::|.|...|...|...|.:||             .:...||.|.||..::....|.:.......:
Zfish  5567 LQQGAKTRLLTLQDAAKDLTRLENDVKSLHQSIERVQETLASPDLARLSLREQLAQRQLLLSEME 5631

  Fly   113 NVSNFI---TWCRKSLKIIE--------C-----LLFETDDL----IMRKN------------EK 145
            .:...:   ..|:.:|::.|        |     |..|:..|    |.:.|            |:
Zfish  5632 GLKQQVQAMQMCQSALRLPEDVMAALPLCVTAQSLQHESSQLQHNTIQQCNILQEALVQYEQYEQ 5696

  Fly   146 HV--ILCLLEVARRGAKFGMLAPMLVQ-MERQID--REIAADIKANGAGCSENGTQTDALETGNS 205
            .|  :..|:|.|.|..:...:|...:| ::.||.  .|:|..||    |..|   |..||   ||
Zfish  5697 EVKNLQRLIEEAHRVIQDRPVATGNIQELQTQIQHHEELALKIK----GYQE---QISAL---NS 5751

  Fly   206 SAATMT------TITTTTVETDLYDDSDDSETEDDGDQNPVLMYGP-QPQIITNDLKSLDEMVRD 263
            ....:|      |:..|..|.|...|..: |.||:.|:.|  .:.| .|.::.........::..
Zfish  5752 KCKMLTVKAKHATMLLTVSEVDGLSDGLE-ELEDEEDEMP--KHPPTHPSVVMMTAGRCHTLLSP 5813

  Fly   264 LVEK---------------CTCPSQFPMVRVSEGKYRIGDTKV---LIFVRILRSHVMVRVGG-- 308
            :.|:               |..||..|....|:|..|...::.   .::...:.|.....:..
Zfish  5814 VTEESGEEGTNSEVSSPPACRSPSPGPNADTSQGSGRAPLSRAPLQELYDPSMESAASANLDDLQ 5878

  Fly   309 -GWDTLSHYLDKHDPCRCRAQHR---------------SSVAARLIPRQSPNHNPSNGIELHKAQ 357
             .|:||.:.:.:.......|..|               .|:...|.....|:.:|.:.:..|:|.
Zfish  5879 RSWETLKNVISEKQKSLYEALERQQHYQETLQSVSTKMESIETALNEGLEPSKSPESQMAAHQAL 5943

  Fly   358 ----VIFERSPPAARRVF--------NSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHSLSPNSG 410
                ::.:....|.:..|        :|...:.|..........|:|..:.......      ||
Zfish  5944 MDEILMLQDEISALQACFSQELQLDEDSLEADAGDQLALQSTLTVLGERMATIHMKA------SG 6002

  Fly   411 KYRSRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQ-----LLGSPSLARRSMSPSPR-- 468
            |   |....:|  ||:|      .......|.:....|..:     ||.:.:....::.|.|:
Zfish  6003 K---RQLLEER--LNEQ------LEEQRQEQALQRYHSEAEELDNWLLSTRATLSSTLQPHPQDM 6056

  Fly   469 -----------RLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGV 522
                       .|:::.:|...|...|...:||     .:|                      |.
Zfish  6057 DMEEQLIDCQNMLLEIEQKVLCLSELSVHSESL-----LLE----------------------GK 6094

  Fly   523 AGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQI 587
            ||.:|.|   |.:|.....:..    ||..:|...|.::: |.|.|:::.|      .|.|||.:
Zfish  6095 AGTRGDA---EQLSLKLHSLKS----SLLELQRILQDKQT-HIQGSLQEQE------DTESDSSL 6145

  Fly   588 SPS----DEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILS-GAHKLSDKFEQSGV 647
            |.|    |..::..:|...:.:|...:.||.:::   :.:..:.|.::.| |...||.:...:|
Zfish  6146 SQSPNMMDWLSQARSTRNQQHQDTVQRQRELEEQ---LGEQKKLLQSVASRGEEILSQRTTPNG- 6206

  Fly   648 FITDDEITVDIAKTED------QSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGAGGSLQ 706
                :....:....||      .|..:.|.....||||..::.| |....:::.:.|...   .|
Zfish  6207 ----ENCPAEFPNGEDGQWPACMSTKDQMRVRWENLSKDLKNKL-QLSLNTMEQTPCNAL---YQ 6263

  Fly   707 DLSSRSG----------LPAPAFSRKQPVYRSVRTRNSTGATTTPVAPPRSRQATQLPMVRDVT- 760
            .:||..|          :|:|. |..:...:.:.....||.|.:    .|||. .|..:.:.|:
Zfish  6264 PVSSPCGVFRGEQLSQDIPSPR-SLFEGFNQDLEDLPQTGGTDS----KRSRD-LQKALYQAVSS 6322

  Fly   761 -NTWSGRTTGAPKRRPPCTAD---TFVAPTNGTGP---------------AGSFERNG-KGRSSQ 805
             :||...........|...:|   ..:....|...               .|..||.. :||.|.
Zfish  6323 ASTWLDNAENELASGPVLLSDDSEAHLVHLEGLNKEVKNVNEEVCKCRDVLGGRERLWVEGRESD 6387

  Fly   806 ILYDSNGRRVRSGAPGCTSSLTT------SPVKNHASS-PLAQQLLEAASSAKNDA--QILEKMK 861
            ::     ..|..|..|....|.|      ..:|:.... .:.|..|....:|.||:  |:|:||.
Zfish  6388 VV-----EEVFDGLEGRLKLLDTVLEQQCDGMKDKLQELTVFQTELRLLLTALNDSKYQLLQKMN 6447

  Fly   862 SLLSRYAA 869
            :.:.|.|:
Zfish  6448 AAMDRPAS 6455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	38/196 (19%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	12/87 (14%)
syne1a	XP_021324303.1	SAC6	37..>300	CDD:227401
		SMC_N	<1428..>1931	CDD:330553
		SPEC	1510..1716	CDD:321951
		SMC_N	<2072..2311	CDD:330553
		SMC_N	<2295..2978	CDD:330553
		SMC_N	3059..>3804	CDD:330553
		SPEC	3445..3656	CDD:238103
		SPEC	3769..3960	CDD:238103
		SMC_N	3843..4677	CDD:330553
		SMC_N	<4593..>4831	CDD:330553
		SMC_N	4879..5752	CDD:330553	54/259 (21%)
		SMC_N	5870..6729	CDD:330553	124/667 (19%)
		SPEC	6668..6839	CDD:321951
		SPEC	6849..7053	CDD:321951
		SPEC	6959..7168	CDD:321951
		SPEC	7096..7276	CDD:321951
		SPEC	7281..7483	CDD:238103
		SPEC	7387..7600	CDD:238103
		SPEC	7709..7924	CDD:238103
		SPEC	7928..8138	CDD:238103
		SPEC	8397..8587	CDD:238103
		KASH	<8697..8731	CDD:313711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900