DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and syne1b

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_009291106.1	Gene:	syne1b / 567576	ZFINID:	ZDB-GENE-071218-4	Length:	8816	Species:	Danio rerio

Alignment Length:	1064	Identity:	199/1064 - (18%)
Similarity:	348/1064 - (32%)	Gaps:	294/1064 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FKSSEEYLEAMREDLAEWLSTLYPELS---INADNFMDRLDTGVALCKHANYVRQAAVDYLARRQ 73
            :|::....:.:.:||:|      .|::   .|..|..|.|          :.:|:.|:..|...|
Zfish   769 YKTATRNAQQLTKDLSE------DEIAHMLNNMTNIKDEL----------SKIRERALPLLRDSQ 817

  Fly    74 ARNKSMTRSMTSGLAGPILAMGNVHYLPAAKS----GTFFARDNVSNFITW---CRKSLKIIECL 131
            |....: ..|...:.|...::.....:.:::.    |.|  .......:|:   |:|.|.:|:
Zfish   818 AMLPPL-EEMEKNITGFYQSLEKASRITSSRDSEAPGDF--TQKCQELVTYQQSCKKCLSVID-- 877

  Fly   132 LFETDDLIMR-----KNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCS 191
              :...:|::     ||.||:...||                   ||:|     .:::|:..|..
Zfish   878 --KNHQVILKSLDTSKNLKHLDTSLL-------------------ERRI-----TELQASSQGMV 916

  Fly   192 ENGTQTDALETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVL-----MYGPQPQIIT 251
            :..|:.......|||  .|.....:.||.:.......|...:.|:...:|     .:|...|.:.
Zfish   917 KETTEWKQHVEANSS--LMKRFEESRVELEKVLKIARSSMTERGNPEDLLKKHTEFFGQLDQRVL 979

  Fly   252 ND-LKSLDEM-----------VRDLVEKC-----TCPSQFPM----VRVSEGKYRI--------- 286
            |. ||:.||:           :::.|.|.     ...::||.    ::|...|.|:
Zfish   980 NAFLKACDELTDILPEQEQQNLQETVRKLHKQWKDVQTEFPYHLLHLKVDLEKSRLMTSLQECQA 1044

  Fly   287 ---GDTKVLIFV---RILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNH 345
               .:.:.|..|   |:::.|.|.....|...|         |..|.||...:..:|...|
Zfish  1045 ELARENRSLPSVGSERLIKEHRMFFKEKGPQAL---------CEKRLQHMDELCLKLPESQ---- 1096

  Fly   346 NPSNGIELHKAQVIFERSPPAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHS-LSPNS 409
                  :..:..||       ||..|                     ..|...:.:.|. |..:.
Zfish  1097 ------QAQQTLVI-------ARTAF---------------------AEVKEEIDSTHQRLMQHP 1127

  Fly   410 GKYR---------SRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGSPSLARRSMSP 465
            .|::         |...|.:...|....|..|..|..|  |..:|..|   |.....|...::|.
Zfish  1128 DKWKEFNTRFSELSAWVTSKESQLRLLRNRAGDPSKFG--QVKSTIES---LRNDAELQEGNVSW 1187

  Fly   466 SPRRLI---------DMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSG 521
            ...||.         |.:::.::|...|:..|   |...|:.|:.  ..|.:.:..|........
Zfish  1188 LKNRLAALIEICTESDAQRQGAALSKLSNDFK---GLLISLSESE--KVVLAVSDCVQFREEVKT 1247

  Fly   522 VAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQ 586
            ...|.....| |..|||...:..|..|.       ||:...||.|..     ...||.:.....|
Zfish  1248 TLEELTQGQK-ELQSDNSKILDSESVRE-------AQQLLLLHQQQL-----KRLRLKRKDMQEQ 1299

  Fly   587 ISPS-----DEPAEKATTDILE---------EEDLNGQDR----------EEDQEDYSVCDGPQS 627
            |:..     :|..|::..|.|:         :|:...|::          |.|.:..||.:....
Zfish  1300 INRGKQLQIEEGLEESLQDDLQKLESTLKKMDENTESQEKNLEVTLSAWQEFDAQQASVREFVGK 1364

  Fly   628 LPAI------LSGAHKLSDKFEQSGVFITDDEITVDIAK---TEDQSVANTMGNPTPNLSKIPRS 683
            :.::      .|....||.:.||          |.|:.|   ||.:.| ||:......:...|::
Zfish  1365 VRSVTEREMNFSSPESLSSELEQ----------TKDLLKQCETEVRQV-NTLLKRATEIQLGPKN 1418

  Fly   684 -PLAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPA---------PAFSRKQPVYRSVRTRNSTGAT 738
             .|.|.:.|::.........|..:|:.:..|:.:         .|||.    :...|.|......
Zfish  1419 QSLLQDQARALSEQVDKVEKGLKRDVKTLEGMKSQWDLFGSEFEAFSS----WIMEREREMDALK 1479

  Fly   739 TTPVAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGK--- 800
            ::.:  |..:|...:..:||.....|...:...::.....  .||:............:.|:
Zfish  1480 SSSI--PLDQQICTVQTIRDGLQERSEVLSNLEEKSQSLV--QFVSSGESARIKARLTQIGRYWE 1540

  Fly   801 ---------------GRSSQILYDSNGRRVRSGAPGCTSSLTTSPVKNHASSPLAQQLLEAASSA 850
                           ..|.|..::||.::|:|........| .:||.:..||....:.|:   |.
Zfish  1541 ELKESVDHLSGQLEESSSHQTKFNSNLQQVQSEVEEIQKKL-DNPVTSCISSSETYKTLQ---SH 1601

  Fly   851 KNDAQILEKMKSLLSRYAAG-----NQTKAGVGATATAAN----------KINSNGKKTPVYEDF 900
            .:..|.|||:|:.|...:||     .:.||.....|...|          |.|........::.:
Zfish  1602 MDVFQSLEKLKATLLSLSAGARRLSEREKAERAVAALQQNYEQCLKQAKEKQNQTESLLSHWQKY 1666

  Fly   901 TTAWVHSNGNLERSE-SCSPPAKA 923
            ...|......|||.| :|.|.:::
Zfish  1667 EKDWSALKSCLERCEAACGPDSQS 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	29/151 (19%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	17/101 (17%)
syne1b	XP_009291106.1	CH	28..134	CDD:237981
		CH	180..278	CDD:278723
		SMC_prok_B	<1031..1748	CDD:274008	142/753 (19%)
		SPEC	1453..1665	CDD:295325	40/223 (18%)
		SPEC	1984..2197	CDD:295325
		SPEC	2107..2306	CDD:295325
		SPEC	2412..2618	CDD:238103
		SPEC	2525..2732	CDD:238103
		SPEC	2737..2948	CDD:295325
		SPEC	2971..3173	CDD:295325
		SPEC	3177..3391	CDD:238103
		SPEC	3393..3600	CDD:295325
		SPEC	3498..3706	CDD:295325
		SPEC	3824..4011	CDD:238103
		SPEC	3927..4145	CDD:238103
		SPEC	4144..4341	CDD:295325
		SPEC	4352..4565	CDD:295325
		SPEC	4461..4674	CDD:295325
		SPEC	4571..4781	CDD:295325
		SPEC	4694..4890	CDD:295325
		SPEC	4892..5103	CDD:295325
		SPEC	5000..5212	CDD:238103
		Smc	5117..>5851	CDD:224117
		SMC_prok_B	5577..6273	CDD:274008
		SPEC	5643..5854	CDD:295325
		Smc	5948..>6680	CDD:224117
		SPEC	6715..6900	CDD:295325
		SPEC	6909..7120	CDD:238103
		SPEC	7019..7227	CDD:238103
		SPEC	7126..7344	CDD:238103
		SPEC	7348..7557	CDD:238103
		SPEC	7456..7663	CDD:238103
		SPEC	7780..7991	CDD:238103
		SPEC	7995..8205	CDD:238103
		SPEC	8457..8676	CDD:238103
		KASH	8759..8816	CDD:287506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900