DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and evpla

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001112369.1	Gene:	evpla / 373136	ZFINID:	ZDB-GENE-030829-19	Length:	1975	Species:	Danio rerio

Alignment Length:	924	Identity:	174/924 - (18%)
Similarity:	307/924 - (33%)	Gaps:	284/924 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SSEEYLEAMRE-----DLAEW----LSTLYPELSINADNFMDRLDTGVALCKHA--NYVRQAAVD 67
            |.|||....::     |.::|    |::||        ::|...|..||..|..  ..::|...|
Zfish   187 SQEEYAAIKKQYANLLDNSKWRRHYLNSLY--------DYMQDCDKEVAYMKEEQNKILKQDWSD 243

  Fly    68 YL-----ARRQARN-KSMTRSMTSGLAGPILAMGN--VHYLPAAKSGTFFARDNVSNFITWCRKS 124
            .:     .|||..| |:.:..........:...|:  :.....|.|.....||.|.|  .| :|.
Zfish   244 QMVDHADVRRQYENFKNNSLLAHESEVNKLQDDGDRLIELKHPAASTVQAQRDTVRN--EW-QKF 305

  Fly   125 LKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAG 189
            |.:..|            .|.|     |:......|:.:.|..|.:...::...:.|. ..||..
Zfish   306 LNLCIC------------QETH-----LDNIEEYKKYQLDADTLSESLSKLGSTVDAK-SVNGKT 352

  Fly   190 CSENGTQTDA----LETGNSSAATM----TTIT-----------TTTVET--------------D 221
            .:|...|..:    |:......|.|    |||.           |||||:              :
Zfish   353 STEIQMQLQSEERPLQRNEQLLADMRKRSTTIVPLKLRRTPPSKTTTVESLCDWKTPKATLNRGE 417

  Fly   222 LYD-----DSDDSETE-DDGDQNP-----VLMYGPQPQIIT---------NDLKSLDEMVRDLV- 265
            |::     |:|:.|.: .||....     .::..|.|:.|.         .|||.....:|.|.
Zfish   418 LFNLKSNTDNDNWEVQSSDGTSQKFPGVCFMIPPPDPEAINRVDLLGKELEDLKKRRAALRTLQN 482

  Fly   266 -EKCTCP-SQFPM--VRVSEGKYRIGDTKVLIFVRILRSHVMVRVGG--GWDTLS---HYLDKHD 321
             ::...| ||.|:  .|..|      :.|..:...  |.:.|.:..|  ..|||:   ..|::.|
Zfish   483 NQQSKAPLSQAPVPAPRAEE------NPKAAVLAN--RLNQMDKDLGQVEMDTLNCIRSPLNRTD 539

  Fly   322 PC-----RCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERS-PPAARRVFNSPNCNGGP 380
            |.     |.:.|.:::.|.:               :|.|.:|..::. .|...:..|.|
Zfish   540 PATDLAKRLQEQEKTTAALQ---------------QLEKQRVAAQKEMEPLLSKDLNGP------ 583

  Fly   381 GTGSSCGTGVVGVAVPPTLQN-------GHSLSPNSGKYRSR---SPTPQRK----------FLN 425
             |.|:            .|||       ..||...:..|:.:   |...:|:          |..
Zfish   584 -TSST------------LLQNLSDAKNKQDSLVALNSLYKKKANASLVLERQLRQMDNTVSGFEK 635

  Fly   426 QQANGGGIASATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSL 490
            |.:..|.|.....:.||.|.:...         .:|.::.|..   :|:|....|::......||
Zfish   636 QLSEDGAIPDKPNAIQTRTQEIQG---------LKRDVAGSQN---EMQKLSEDLEALKKLCSSL 688

  Fly   491 PGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQS 555
                                              :||......:|....:|:.:...|...||..
Zfish   689 ----------------------------------QQGYQEYCPDIRRQEAEVKNLQSRYSNVINQ 719

  Fly   556 GAQKRESLHSQASIED------AESNARLDQTSSDSQISPSDEPAE---------KATTDILEE- 604
             ..:||.|..:|:.:.      ::|.:.|.....|:::||.|:.::         :...||..:
Zfish   720 -LSERERLLQEANTKHQDFQNVSQSLSLLLDNLPDNKVSPKDDLSQIQAKQNSQKRVIEDIQRKG 783

  Fly   605 EDLN-----GQDREEDQEDYSV-CDGPQSL--PAILSGAHKLSDKFEQSGVFITDDEITVDIAKT 661
            :|:|     .:|.:....:|.| ||..:::  ...::.|.:|......|.|...:.::|...|:|
Zfish   784 DDMNRVVDLSKDLQNVLNEYEVNCDKYKAILDDTTVTNAKRLHTSTLASSVAKQEKDLTKQYAET 848

  Fly   662 EDQS------VANTMGNPTPNLSKI------PRSPLAQR-----------------RRRSIDNST 697
            ..:|      :....|..|.|:.::      .:..|.|:                 :|.:.:| |
Zfish   849 AAESDQLLKQINFAKGIVTENVEQVNTIQQQQQQQLQQKAFEDTEVLQKELKEEIAKRTNAEN-T 912

  Fly   698 CGGAGGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATTTPV---APPRSRQATQLPMV-RD 758
            .|........|.||.|:...........||..:.:.|.......:   |..|::..:::.:: |.
Zfish   913 LGTIKSRYLSLKSRRGIERVEEKEILQYYRDPKLQASVDDFQKKIHEEALKRTKTQSEIEVLNRK 977

  Fly   759 VTNTWSGRTTGAPK 772
            :|:..|......||
Zfish   978 ITSLESELKNTKPK 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	31/155 (20%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	18/81 (22%)
evpla	NP_001112369.1	SPEC	215..>361	CDD:295325	36/174 (21%)
		SPEC	655..798	CDD:295325	29/189 (15%)
		Smc	893..1656	CDD:224117	18/100 (18%)
		Plectin	<1665..1695	CDD:279071
		Plectin	1784..1817	CDD:279071
		Plectin	1814..1855	CDD:279071
		PLEC	1851..1886	CDD:197605
		Plectin	1890..1931	CDD:279071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900