DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pigs and Gas2l1

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_006251402.1	Gene:	Gas2l1 / 360973	RGDID:	1311206	Length:	678	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	249/836 - (29%)
Similarity:	348/836 - (41%)	Gaps:	240/836 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARPYRPFKSSEEYLEAMREDLAEWLSTLYP-ELSINADNFMDRLDTGVALCKHANYVRQAAVDYL 69
            |:..|||:|||.|:|||:||||:||:.||. .|..:.|.|:..|.||..||:|||.|.:||....
  Rat    13 AKSVRPFRSSEAYVEAMKEDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTKAARALA 77

  Fly    70 ARRQARNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFE 134
            |.|..|                   |......:...|:|.|||||::||.|||..|.:.|.|:||
  Rat    78 AARPTR-------------------GVAFQAHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFE 123

  Fly   135 TDDLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDA 199
            |:||::|||||.|:|||||||||||:.|:|||.|||.|::|:||:.|..:|:....:|.    |.
  Rat   124 TEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELRATPQASSVPAAEE----DV 184

  Fly   200 LETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDL 264
            .|...:..|...|                                  |::..||:::|||:||::
  Rat   185 TEIAAAPGAPART----------------------------------PRMTPNDIRNLDELVREI 215

  Fly   265 VEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQ- 328
            :.|||||.||||::|||||||:||:.:|||||:||:|||||||||||||.|||||||||||.:.
  Rat   216 LGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRCTSST 280

  Fly   329 HRSSVAARLIPRQ----------SPNHNPSNGIELHKAQVIFERSP-PAARRVFNSP-------- 374
            ||       :|:|          ||..:|..|            || |.:.|..:.|
  Rat   281 HR-------LPQQRTGTFSPQRGSPTPSPRPG------------SPVPGSERRSSRPEVTPISLR 326

  Fly   375 NCNGGPGT------------------------GSSCGTGVVGVAVPPTLQNGHSLSPN----SGK 411
            :...||.|                        .||..:|.:|.....:........||    ||.
  Rat   327 STKEGPETPLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPMGARSDDSATGSRRERPNHRLTSGL 391

  Fly   412 YRS--RSPTPQRKFLNQQANG------GGIASATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPR 468
            ..|  |.|||:.:..::...|      ||..:...:|              ||:...||.:...:
  Rat   392 TASPRRPPTPRSQSRDRLDRGRPRMAPGGRGAQLSAS--------------SPARRTRSQNREEQ 442

  Fly   469 RLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQG-GANKF 532
            .::.:|:.:....|:           .:.....|||| ||......:..|.|..|.... |.:..
  Rat   443 AVLVVRRDRDGQHSW-----------VARGRGGGGSG-GSGRSTPQTPRARSPAAPRPSRGPSPG 495

  Fly   533 ENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNAR-LDQTSSDSQI-SPSDEPAE 595
            ..::...:.|    :|:  .:|...|:.:.|..:.. |:..:||| |:..:|.:.: |..|.||
  Rat   496 PELAATPASI----FRT--PLQLDPQQEQQLFRRLE-EEFLANARALEAAASHTLMGSAPDHPA- 552

  Fly   596 KATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEITVDIAK 660
                                 .|.:.|....|    .|....|..|..|               .
  Rat   553 ---------------------PDSAYCSSSSS----SSSLSVLGGKCGQ---------------P 577

  Fly   661 TEDQSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPV 725
            .|....||  |.|.|....:..|        |.:.|.|...|.:|.  ::||.|..|     :|.
  Rat   578 RESGRTAN--GLPAPRSQALSSS--------SDEGSPCLAVGRTLD--AARSSLAGP-----EPS 625

  Fly   726 YRSVRTRNST------GATTTPVAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRP 775
            ....|.|..|      ....||..|.|....|:|       ..|....:..|:..|
  Rat   626 LTWARGRMDTQPDRKPSRIPTPRGPRRPSGPTEL-------GAWHALHSVTPRTEP 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	62/137 (45%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	51/66 (77%)
Gas2l1	XP_006251402.1	CH	29..148	CDD:237981	62/137 (45%)
Gas2l1	XP_006251402.1	GAS2	209..276	CDD:280367	51/66 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334399
Domainoid	1	1.000	131	1.000	Domainoid score	I5063
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343422at2759
OrthoFinder	1	1.000	-	-		FOG0001647
OrthoInspector	1	1.000	-	-		oto98376
orthoMCL	1	0.900	-	-		OOG6_107791
Panther	1	1.100	-	-	O	PTHR46756
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3764
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750