DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and Syne2

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001005510.2	Gene:	Syne2 / 319565	MGIID:	2449316	Length:	6874	Species:	Mus musculus

Alignment Length:	918	Identity:	165/918 - (17%)
Similarity:	298/918 - (32%)	Gaps:	287/918 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ETDDLIMRKNEKHVILCLLEVARR-GAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQT 197
            :.::.||.|..|.....|.::..| ..:.|:|...|...:.::..:.|::.:.:.|.......:.
Mouse  1094 QQEESIMEKEGKDCSASLSDLQERYDTQRGLLEQHLQDSKSRVTSDFASEQERSSACLQSKLAEL 1158

  Fly   198 DALETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGD---QNPVLMYGPQPQIITNDLKSLD- 258
            ..|.....:......||:..:.. |..|::......:.|   .|..:::|    ::...::||:
Mouse  1159 QVLLADTDAHWEKFEITSLNLRR-LMSDAEKPVLNQERDLLKGNEQVLHG----LLNTRMESLEM 1218

  Fly   259 --EMVRDLVEKCT--CPSQFPMVRVS---------EGKYRIGDTKVLIFVRILRSHV--MVRVGG 308
              ::|..|.::|:  |.|..|:..|:         :|.|:        .:|.:|..:  .:||..
Mouse  1219 ALQIVLPLEKECSLLCASDLPLCTVAVQDLHPVEIDGVYQ--------NLRDIRDSIAKQIRVCT 1275

  Fly   309 GWDTLSHYLDKH----DPC-------RCRAQ--------------------HRSSVAARLIPRQS 342
            ..:..|:.:.:.    |.|       :||.|                    ..:|:.|..:..:.
Mouse  1276 SLEEPSNSVPRELHTLDQCAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAEL 1340

  Fly   343 PNHNP--------SNGIELHKAQVIFERSPPAARRV----FNSPNCNGGPGTGSSCGTGVVGVAV 395
            |...|        |..|.|.|     |::.|...|:    .|..:..||..|......|.:.|
Mouse  1341 PADRPAPKAPEVLSEDILLMK-----EKAGPLDERLRTLGINIKDAEGGENTTCERLVGALSV-- 1398

  Fly   396 PPTLQNGHSLSPNSGKYRSRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGSPSLAR 460
                    :|....|:.:...|...:|.|  :|..........:.|.:....|...|....:.|.
Mouse  1399 --------NLVAMDGQSKEEGPPEDKKLL--EACSSKNLELFKNIQDLQNQISKIGLKDPTAPAV 1453

  Fly   461 RSMSPSPRRL-----------IDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVS 514
            :....|..||           :.::|...||..:..|.:......|....|...|...|....:
Mouse  1454 KHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWESTKASVTESL- 1517

  Fly   515 SGSAGSGVAGEQGGA-----NKFENISDNGSEI--SDEGYRSLGVIQSGAQKRESLHSQ-ASIED 571
                      ||.|:     .:::||.:|.:.:  .:||..|.   |:....:::|..: |.||.
Mouse  1518 ----------EQCGSALELLRQYQNIKNNLTALIQKEEGIISQ---QASYMGKDNLKKKIAEIET 1569

  Fly   572 A--ESNARLDQTSSDSQISPS------------DEPAEKATTDILEE-EDLNGQDREEDQEDYSV 621
            .  |.:..|:.....:||..:            |.|.||....|::. .|:|     |..|:|.
Mouse  1570 VKEEFSDHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDIN-----EKTEEYG- 1628

  Fly   622 CDGPQSLPAILSGAHKLSDKFEQSGVFITD---DEITVDI-AKTEDQSVANTMGNPTPNLSKIPR 682
                ::|...|:    |.||     :||..   ||.|..| .|.|...:............|:..
Mouse  1629 ----ENLGRALA----LWDK-----LFIIKNNIDEWTEQILGKAESHELTEEDRGRLKEELKVLE 1680

  Fly   683 SPLAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATTTPVAPPRS 747
            ...|:..||..|          :|.|..         |.::|:...|
Mouse  1681 EQSAEFSRRVAD----------IQSLLQ---------SNEKPLELQV------------------ 1708

  Fly   748 RQATQLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGKGRSSQILYDSNG 812
            .:::.|..::||....:|                   .:|...|:||        ::::..|.:.
Mouse  1709 MESSVLSKMKDVKTHVAG-------------------GSNSYAPSGS--------TAELREDLDQ 1746

  Fly   813 RRVRSGAPGCTSSLTTSPVKNHASSP------------LAQQLLEAASSAKNDAQILE------- 858
            .:.:.   |.|.||.      :|.||            :.||:.:    .|:...:||
Mouse  1747 AKTQM---GMTESLL------NALSPSDSLEIFTKLEEIQQQIFQ----QKHSMTVLENQIGCLT 1798

  Fly   859 -KMKSLLSRYAAGNQTKAGVGATATAANKINSNGKKTPVYEDFTT----------AWVHSNGNLE 912
             ::..|..:|             |:.:|..|:  ||..:.:.|.|          .| .||....
Mouse  1799 PELSELKRQY-------------ASVSNLFNT--KKNALQDHFATFLNEQCKNFNDW-FSNVKTN 1847

  Fly   913 RSESCSPP 920
            ..|...||
Mouse  1848 LQECFEPP 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	6/25 (24%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	16/93 (17%)
Syne2	NP_001005510.2	Actin-binding	1..286
		CH	33..135	CDD:237981
		CH	184..283	CDD:278723
		Spectrin 1	299..380
		Spectrin 2	381..474
		Spectrin 3	475..577
		Spectrin 4	578..680
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..723
		Spectrin 5	727..834
		Smc	806..1698	CDD:224117	126/676 (19%)
		Spectrin 6	835..928
		Spectrin 7	929..1030
		Spectrin 8	1120..1211		13/95 (14%)
		Spectrin 9	1262..1322		9/59 (15%)
		Spectrin 10	1323..1409		19/100 (19%)
		Spectrin 11	1410..1514		19/105 (18%)
		PRK03918	<1414..2000	CDD:235175	105/570 (18%)
		Spectrin 12	1515..1626		26/129 (20%)
		Spectrin 13	1627..1728		28/170 (16%)
		Spectrin 14	1729..1820		23/126 (18%)
		Spectrin 15	1821..1928		8/36 (22%)
		Spectrin 16	1929..2026
		SPEC	1934..>2076	CDD:295325
		Spectrin 17	2027..2122
		Spectrin 18	2123..2233
		Smc	2167..3049	CDD:224117
		Spectrin 19	2234..2350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2338..2397
		Spectrin 20	2422..2503
		Spectrin 21	2504..2610
		Spectrin 22	2611..2707
		SMC_prok_B	2692..>3557	CDD:274008
		Spectrin 23	2708..2821
		Spectrin 24	2822..2923
		Spectrin 25	2924..3027
		Spectrin 26	3028..3133
		Spectrin 27	3134..3239
		Spectrin 28	3240..3343
		Smc	3247..4049	CDD:224117
		Spectrin 29	3344..3456
		Spectrin 30	3457..3563
		Spectrin 31	3564..3669
		Spectrin 32	3670..3767
		Spectrin 33	3768..3870
		Spectrin 34	3871..3976
		Spectrin 35	3977..4074
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4062..4152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4171..4193
		Spectrin 36	4218..4337
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4326..4348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4401..4429
		Spectrin 37	4507..4626
		Spectrin 38	4627..4714
		Spectrin 39	4715..4823
		Spectrin 40	4824..4929
		SPEC	4868..5039	CDD:295325
		Spectrin 41	4930..5037
		Spectrin 42	5038..5150
		SPEC	5049..>5218	CDD:238103
		Spectrin 43	5151..5252
		Spectrin 44	5253..5377
		SPEC	5302..5446	CDD:295325
		Spectrin 45	5378..5473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5435..5459
Spectrin 46	5474..5576
Spectrin 47	5577..5691
Spectrin 48	5692..5786
Spectrin 49	5787..5894
Spectrin 50	5895..6004
SPEC	5906..6120	CDD:238103
Spectrin 51	6005..6122
Spectrin 52	6123..6230
SPEC	6124..6334	CDD:238103
Spectrin 53	6231..6342
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6336..6473
Spectrin 54	6450..6534
Spectrin 55	6535..6650
SPEC	6539..6756	CDD:238103
Spectrin 56	6651..6767
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6790..6812
KASH	<6845..6874	CDD:287506
Sufficient for interaction with SUN2. /evidence=ECO:0000250\|UniProtKB:Q8WXH0	6861..6874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900