Protein Alignment pigs and GAS2L2

DIOPT Version :9

• Sequence 1: NP_001245550.1
• Gene: pigs / 31596
• FlyBaseID: FBgn0029881
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_644814.1
• Gene: GAS2L2 / 246176
• HGNCID: 24846
• Length: 880
• Species: Homo sapiens
• Alignment Length: 1094
• Identity: 285/1094 - (26%)
• Similarity: 394/1094 - (36%)
• Gaps: 445/1094 - (40%)

  Fly    10 RPFKSSEEYLEAMREDLAEWLSTLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQA 74
            |||||||:|||||:|||||||..|| .|.|:|.||:..|:||:.||:|||.|..||:.:||...|
Human    22 RPFKSSEQYLEAMKEDLAEWLRDLY-GLDIDAANFLQVLETGLVLCQHANVVTDAALAFLAEAPA 85

  Fly    75 RNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLI 139
            :.:.:          |:..:| |....||:.|||.|||||||||.||||.:.|.|.|:|||:||:
Human    86 QAQKI----------PMPRVG-VSCNGAAQPGTFQARDNVSNFIQWCRKEMGIQEVLMFETEDLV 139

  Fly   140 MRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDALETGN 204
            :|||.|:|:|||||:.||..:||:.||.|||:|.:|:.|:..::               ||
Human   140 LRKNVKNVVLCLLELGRRAWRFGVAAPTLVQLEEEIEEEVRREL---------------AL---- 185

  Fly   205 SSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVEKCT 269
                                        ...|.:|......||    ...::||:||:.||..||
Human   186 ----------------------------PPPDPSPPAPPRRQP----CHFRNLDQMVQSLVSHCT 218

  Fly   270 CPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVA 334
            ||.||.||:|||||||:||:..|||:||||:|||||||||||||.|||||||||||
Human   219 CPVQFSMVKVSEGKYRVGDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRC--------- 274

  Fly   335 ARLIPRQSPNHNPSNGIELHKAQVIFERSPPAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPT- 398
                  .|.:|.|.:.::           |||                             ||.
Human   275 ------TSLSHKPGSFLK-----------PPA-----------------------------PPVQ 293

  Fly   399 ----LQNGHS-LSPNSGKYRSRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGSPSL 458
                :|:|.| ..|.....||:||.|...:                    .|.|||.:.|..|:
Human   294 HEVRVQDGPSQTQPTMTISRSQSPPPPVDW--------------------KTYTSSDRRLRPPT- 337

  Fly   459 ARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVA 523
               ..||.|||                                             ...||:|.:
Human   338 ---PSSPRPRR---------------------------------------------ERGAGTGAS 354

  Fly   524 GEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQIS 588
            .|.....:.:.             |||  |.|..|                     .|:.||..|
Human   355 REMAPFLRCQE-------------RSL--IPSWRQ---------------------PTAGDSPPS 383

  Fly   589 PSDEPAEKATTDILEEEDLNGQDRE-----EDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVF 648
            |.....:|            |:|.:     :.:|.|     |..||.
Human   384 PQSSSTQK------------GRDPQCTSSGKREERY-----PPELPR------------------ 413

  Fly   649 ITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGAGGSLQDLSSRSG 713
               ..|.......|..|.....|||||            :|.|:|:.:|.|        :|:|..
Human   414 ---GRIPTSWVHEETDSWGTDAGNPTP------------QRLRAIEATTKG--------ISARGP 455

  Fly   714 LPAPA----------------------FSRKQPVYRSVRTRNST-GATTTPVAPPRSRQATQLPM 755
            .|.|.                      |..::|  .|||:.... |.|..|:..|.:|..|.
Human   456 SPLPRSFGPAECLGLRLPLRDEAKGAFFQFREP--ESVRSPTPVQGLTKIPIRLPPARPPTP--- 515

  Fly   756 VRDVTNTWSGRTTGAPKR---RPP-----------------CTADT----------FVAPTNGTG 790
                ..::.|.|:|:|:.   |.|                 |:.:.          .:|....:.
Human   516 ----GRSFPGATSGSPRTELGRDPIPLRAVTVDLAGSTHGDCSVEVRQEDQQLDIQVMAEARESW 576

  Fly   791 PAGSFERNGK-------GRSSQILYDS-------NGR--RVRSGAPGCTSS--LTTSPV------ 831
            ..|..|:.|:       |...|.:|.|       |.:  .|||..|..|.|  :..|.|
Human   577 DLGLQEQEGRYTPLPLGGNKEQAIYCSLEEEILGNMKLLEVRSACPQGTRSGVIPRSGVYIPRLA 641

  Fly   832 ---------KNHASSPLAQ----------QLLEAASSAKNDAQILE---KMKSLLSRYAAGNQTK 874
                     .:.|...|||          :..:||.:......:..   .:|..|....:|.:||
Human   642 GQWPEPGGPYDKAIQELAQGSPSLLKVDLEAWKAAPTGSPKPAVTPGPGSLKGKLGARQSGPRTK 706

  Fly   875 AGVGATATAANKINSNGKKTPVYEDFTTAWVHSNGNLERSESCSPPAKARSKRSSAASSCESNNS 939
            |.:.|..|...|:...|                      .:.||....:.|..:...|..:.|:.
Human   707 ASLSAKGTHMRKVPPQG----------------------GQDCSASTVSASPEAPTPSPLDPNSD 749

  Fly   940 NAGAGSGAAAGSASVVSPRR---------------------ERGMSKIPAPVRH 972
            .|.|  ..:.|..::..|:|                     |:..|:||.|:.:
Human   750 KAKA--CLSKGRRTLRKPKRVPSIYKLKLRPRIRPRRDHRPEKQPSRIPRPLAY 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	70/136 (51%)
		GAS2	258..325	CDD:280367	51/66 (77%)
GAS2L2	NP_644814.1	CH	34..159	CDD:237981	70/136 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..200		4/66 (6%)
		GAS2	207..274	CDD:280367	51/66 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..360		29/185 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..437		20/123 (16%)
		Interaction with ADORA2A. /evidence=ECO:0000250|UniProtKB:Q5SSG4	438..880		75/405 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..533		13/50 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..880		26/150 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5370
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343422at2759
OrthoFinder	1	1.000	-	-		FOG0001647
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46756
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3764
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.920