DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and Gas2l2

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001013781.1	Gene:	Gas2l2 / 237891	MGIID:	3652048	Length:	860	Species:	Mus musculus

Alignment Length:	994	Identity:	283/994 - (28%)
Similarity:	393/994 - (39%)	Gaps:	300/994 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RPYRPFKSSEEYLEAMREDLAEWLSTLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYLAR 71
            |..|||||||:|||||:|||||||..|| .|.|:||||:..|:||:.||:|||.|.:||:.:||.
Mouse    19 RSIRPFKSSEQYLEAMKEDLAEWLRDLY-GLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAE 82

  Fly    72 RQARNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETD 136
            ...|.:.:.           :....|....||:.|||.||||:||||.||||.:.|.|.|:|||:
Mouse    83 APERAQKIP-----------MPQAGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETE 136

  Fly   137 DLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDALE 201
            ||::|||.|.|:|||||:.||..:||:.||.||.:|.:||.|:..|:               ||.
Mouse   137 DLVLRKNVKSVVLCLLELGRRAWRFGVAAPALVHLEEEIDEELRRDL---------------ALP 186

  Fly   202 TGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVE 266
            :                                .|..|.:....:|....|    ||:||:.||.
Mouse   187 S--------------------------------PDPPPPIPPARRPCHFHN----LDQMVQSLVS 215

  Fly   267 KCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRA---- 327
            .||||.||.||::||||||:||:..|||:||||||||||||||||||.|||||||||||.:
Mouse   216 HCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHK 280

  Fly   328 ------------QHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERSPPAARRVFNSPNCNGGP 380
                        ||...|       |.....|...:.:.::|   ...||...:.:.|.:....|
Mouse   281 PGSFLKPPGPPVQHEVKV-------QDGPSQPQPTMTISRSQ---SPLPPVDWKTYTSSSRKLRP 335

  Fly   381 GTGSSCGTGVVGVAVPP----TLQNG---HSLSPNSGKYRSRSPTPQRKFLNQQANGGGIASA-- 436
            .|.||.|..    :.||    ||:..   .|....:...|..||.||   .:....|..:.|.
Mouse   336 PTPSSPGLR----SEPPVRARTLREDPLPRSQEKPTPSQRMSSPGPQ---FSSTCRGPDLQSTLS 393

  Fly   437 ------------TGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRL--IDMRKKQSSLDSYSSGP 487
                        .|.:.|:.....:|      |....:.:|:|:||  .:...|::|    :.||
Mouse   394 GKRANRCPGEPPRGRTPTLWVHKEAG------SRGTHTKAPTPQRLQIPEATSKRTS----ARGP 448

  Fly   488 KSLPGYSCSMEEAN-------GGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDE 545
             |.|..|.|:...:       |.|...|....|.|.|.|.|:.......:.....:...|.:..|
Mouse   449 -SPPPRSSSLASPHMIWVLHQGASPQLSEPMTVHSSSPGKGLTKIPIRLSPARPPTPGRSSLGTE 512

  Fly   546 GYRSL--GVIQSGAQK---RESLHSQASIEDAESNARLDQTSSDSQISPS--------------- 590
            |..|.  |.|.|.|.:   ..|.|...|:|.:..:....||:|:::...|
Mouse   513 GEYSTGRGSISSRALEGNLDRSTHGHHSVEASGDHQTDIQTTSETEDPRSLGTQKWKERHTSLAL 577

  Fly   591 DEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEIT 655
            ....|:|..|.|:||.:......|....|:.....|::|              :|||::
Mouse   578 GRRREQALYDNLKEEVVANMKLLEVGTAYTQGTRSQAIP--------------RSGVYV------ 622

  Fly   656 VDIAKTEDQSVANTMGNPTPNLSKIPRS------PLAQRRRRSID------NSTCGGAGGSLQDL 708
                    .|:......|.....|:.|.      ||.:     :|      .|.|
Mouse   623 --------PSLGGRWPEPGGPYDKVIRELVQGPPPLLK-----VDLKAWKVGSEC---------- 664

  Fly   709 SSRSGLPAPAFSRKQPV----YRSVRTR-----NSTGATTTPVAPPRSRQATQLPMVRDVTNTWS 764
                 ||.|......|.    .|...||     |:...|...|:|.|.:
Mouse   665 -----LPRPIVDPGSPKEKLGSRETGTRIKASLNAEDTTVRTVSPARGQ---------------- 708

  Fly   765 GRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERN---GKGRSS-------QILYDSNGR-RVRSG 818
            |.:|      ||.:|: ..|||.......|.:.:   |||:.:       ..:|....| |:|
Mouse   709 GCST------PPVSAN-LEAPTRSCSDPSSDKASVCLGKGKRTLRKPQKIPSIYKLKLRPRIR-- 764

  Fly   819 APGCTSSLTTSPVKNH--------ASSPLAQQLLEAASSAKNDAQILEKMKSLLSRYAAGNQ-TK 874
                       |.::|        ...||....|                  :|:|.|.|:: .|
Mouse   765 -----------PRRDHRPEKRPSRIPKPLPYSCL------------------VLARTAPGSRLLK 800

  Fly   875 AGVGATATAANKINSNGKK 893
            |.:|.......::|..|||
Mouse   801 ATLGGKGGVPCQVNGTGKK 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	68/136 (50%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	51/66 (77%)
Gas2l2	NP_001013781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		1/2 (50%)
		CH	34..159	CDD:237981	68/136 (50%)
		GAS2	207..274	CDD:280367	51/66 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..459		42/205 (20%)
		Interaction with ADORA2A and GNAS. /evidence=ECO:0000269\|PubMed:23994616	431..860		100/496 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..574		22/100 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..743		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..781		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..860		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5228
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3091
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343422at2759
OrthoFinder	1	1.000	-	-		FOG0001647
OrthoInspector	1	1.000	-	-		otm44096
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46756
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.930