DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pigs and MACF1

DIOPT Version :9

Sequence 1:NP_001245550.1 Gene:pigs / 31596 FlyBaseID:FBgn0029881 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001380991.1 Gene:MACF1 / 23499 HGNCID:13664 Length:7555 Species:Homo sapiens


Alignment Length:395 Identity:92/395 - (23%)
Similarity:144/395 - (36%) Gaps:135/395 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 TTITTTTVETDLYDDSDD---------SETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVE 266
            ||....|...|::|...|         :....:.|     .|.|     |.|...:::.|...|.
Human  7178 TTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-----AYRP-----TTDADKIEDEVTRQVA 7232

  Fly   267 KCTCPSQFPMVRVSEGKYR------IGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRC 325
            :|.|..:|.:.::.|.|||      .||::.|..||||||.|||||||||..|..:|.|:||||.
Human  7233 QCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV 7297

  Fly   326 --------RAQHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFE--------------RSPPAAR 368
                    |:...||:::     |||.......|||.:..::.|              ||.|::|
Human  7298 HHPGSKIKRSDSSSSISS-----QSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR 7357

  Fly   369 RVFNSP------------NCNGGPGTGSSCGTG---------------VVGVAVPPTLQNGHS-- 404
            ..  ||            :|...|.:.::..:|               :|.......:::.||  
Human  7358 AA--SPTRSSSSASQSNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPD 7420

  Fly   405 -------LSPNSG-KYRSRSPT-----------------------------PQRKFLNQQANGGG 432
                   :.|:|| |.:..:||                             |::......:..|.
Human  7421 LQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGS 7485

  Fly   433 IASATGSS--------------QTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSY 483
            .|.:..||              |:..:|||.....|....:||.:: .|.::..|.||.::....
Human  7486 RAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLN-KPSKIPTMSKKTTTASPR 7549

  Fly   484 SSGPK 488
            :.|||
Human  7550 TPGPK 7554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pigsNP_001245550.1 CH 22..159 CDD:237981
GAS2 258..325 CDD:280367 33/72 (46%)
MACF1NP_001380991.1 SAC6 36..>292 CDD:227401
SPEC 581..675 CDD:197544
SPEC 677..866 CDD:238103
SPEC 1159..1338 CDD:413338
PLEC 1764..1800 CDD:197605
PLEC 1807..1838 CDD:197605
PLEC 2285..2317 CDD:197605
PLEC 2681..2718 CDD:197605
SbcC <3364..3905 CDD:223496
SPEC 3486..3722 CDD:238103
SPEC 3878..4106 CDD:238103
Smc 4187..5025 CDD:224117
SMC_prok_B 4877..5807 CDD:274008
SPEC 5343..5556 CDD:238103
SPEC 5778..5990 CDD:238103
SPEC 5888..6104 CDD:238103
SPEC 6106..6323 CDD:238103
SPEC 6326..6542 CDD:238103
SPEC 6547..6761 CDD:238103
SPEC 6766..6978 CDD:238103
SPEC 6988..7112 CDD:197544
EFh 7146..7208 CDD:238008 6/29 (21%)
GAS2 7221..7296 CDD:128539 32/74 (43%)
PHA03307 7379..>7553 CDD:223039 27/174 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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