DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and SYNE1

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_006715470.1	Gene:	SYNE1 / 23345	HGNCID:	17089	Length:	8846	Species:	Homo sapiens

Alignment Length:	1041	Identity:	187/1041 - (17%)
Similarity:	352/1041 - (33%)	Gaps:	276/1041 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KSSEEYLEAMREDLAEWLSTLYPELSINADNFMDRLDTGVA-LCKHANYVRQ-----------AA 65
            |..:..||||.|.| ::|:::|         ..:::...|| |.:....:||           ||
Human  5584 KEIDSELEAMTEKL-QYLTSVY---------CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA 5638

  Fly    66 VDY------LARRQARNKSMTRSMTSGLAGPILAMGNV----HYLPAAKS------------GTF 108
            .|.      |.:.||..:....::||...|.:.....:    |.|...:|            ...
Human  5639 KDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL 5703

  Fly   109 FARDNVSNFITWCRKSLKIIE------------CLLFETDDLIMRKNE---KHVILCLLEVARRG 158
            ...::|...:..|..:|::.|            |.:.:...:...:.|   || :..|:|.|.|.
Human  5704 RIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKH-LQQLIEGAHRE 5767

  Fly   159 AKFGMLAPMLVQ-MERQIDR--EIAADIKANGAGCSENGTQTDALETGNSSAATMTTITTTTVET 220
            .:...:|...:| ::.||.|  |:|..||......:...::...| |..:..||| .:|.|.||
Human  5768 IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML-TMKAKHATM-LLTVTEVE- 5829

  Fly   221 DLYDDSDDSE----------------------------TEDDGDQ-------NPVLMYGPQP--- 247
            .|.:.::|.:                            ||:.|::       :|.....|.|
Human  5830 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVAN 5894

  Fly   248 --QIITNDLK-----SLDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVR 305
              ..:..|:.     |.:.:..|..:      ..|....|:..|..|          |......:
Human  5895 TDASVNQDIAYYQALSAERLQTDAAK------IHPSTSASQEFYEPG----------LEPSATAK 5943

  Fly   306 VGG---GWDTLSHYLDK---------------HDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIE 352
            :|.   .|:||.:.:.:               .|..:..:....::..:|.....|..:|.:.:.
Human  5944 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMA 6008

  Fly   353 LHKA--QVIFE------------RSPPAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGH 403
            .|::  |.:.:            :|..|...|  |.:|...|..         .:|:..||.
Human  6009 EHQSFLQALMDEILMLQDEINELQSSLAEELV--SESCEADPAE---------QLALQSTLT--- 6059

  Fly   404 SLSPNSGKYRSRSPTPQRKFLNQQANGGGIASATGSSQTV-----TTDTSSGQLLGSPSLARRSM 463
            .|:......|.:: :.:|:.|.::.|..  .......|.:     ..|.....||.:.:....::
Human  6060 VLAERMSTIRMKA-SGKRQLLEEKLNDQ--LEEQRQEQALQRYRCEADELDSWLLSTKATLDTAL 6121

  Fly   464 SPSPRR--------------LIDMRKKQSSLDSYSSGPKS--LPGYSCSMEEANGGSGVGSAAGG 512
            || |:.              |:::.:|..:|...|...::  |.|.:.:.:||       ....|
Human  6122 SP-PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEA-------EQLAG 6178

  Fly   513 VSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGA--------------QKRESL 563
            ......||.:..::...:|..|:....::..:|....|...||..              |::.||
Human  6179 KLRRLKGSLLELQRALHDKQLNMQQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSL 6243

  Fly   564 HSQASIED--AESNARLDQTSSDSQISPSDEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQ 626
            ..|..:|.  ||..:.|...:|..:.......|.:.:.|..|:.|:..|:...:.|..|..|
Human  6244 QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED--- 6305

  Fly   627 SLPAILSGAHKLSDKFEQ-SGVFITDDEITVDIAKTEDQSVANTMGNPTPNLSKIP--RSPLAQR 688
                      ::..|:|. ...|.|..::..::.:.|.:.|  ....|...||.:|  :..:..:
Human  6306 ----------QMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQ 6358

  Fly   689 RRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATTTPVAPPRSRQATQL 753
            .:.:: .|...|...:.:::||:||     .:::|.::...:..:...||:|
Human  6359 DKSAV-TSLLDGLNQAFEEVSSQSG-----GAKRQSIHLEQKLYDGVSATST------------- 6404

  Fly   754 PMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGKGRSSQILYDSNG--RRVR 816
             .:.||.......|...|:....|..:..:...:....:...::| |...|| .:..||  |.|.
Human  6405 -WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN-KNLFSQ-AFPENGDNRDVI 6466

  Fly   817 SGAPGC---TSSLTTSPVKN--HASSPLAQQLLE--------AASSAKNDAQILEKMKSLLSRYA 868
            ....||   ..||..|.|..  |......||:|.        ..|.|.|...||:|:.::..:..
Human  6467 EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV 6531

  Fly   869 A 869
            |
Human  6532 A 6532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	34/185 (18%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	11/84 (13%)
SYNE1	XP_006715470.1	CH	28..141	CDD:237981
		CH	187..285	CDD:278723
		SPEC	1454..1661	CDD:295325
		SPEC	1663..1874	CDD:238103
		SPEC	2417..2622	CDD:238103
		SPEC	2523..2739	CDD:238103
		SPEC	2741..2944	CDD:295325
		SPEC	3072..3283	CDD:238103
		SPEC	3184..3395	CDD:238103
		SPEC	3397..3602	CDD:295325
		SPEC	3824..4042	CDD:238103
		SPEC	4148..4344	CDD:295325
		SPEC	4273..4459	CDD:295325
		SPEC	4493..4677	CDD:295325
		SPEC	4895..5088	CDD:295325
		SPEC	5003..5216	CDD:238103
		SPEC	5535..>5697	CDD:295325	26/122 (21%)
		SPEC	5643..5842	CDD:295325	41/202 (20%)
		SMC_prok_B	5944..6730	CDD:274008	115/651 (18%)
		SPEC	5971..6196	CDD:295325	38/249 (15%)
		SPEC	6808..7030	CDD:295325
		SPEC	6926..7137	CDD:238103
		SPEC	7046..7244	CDD:238103
		SPEC	7173..7361	CDD:295325
		SPEC	7365..7567	CDD:238103
		SPEC	7469..7680	CDD:238103
		SPEC	7793..8008	CDD:238103
		SPEC	8012..8222	CDD:238103
		SPEC	8476..8709	CDD:238103
		KASH	<8814..8845	CDD:287506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900