DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pigs and EVPL

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001307676.1	Gene:	EVPL / 2125	HGNCID:	3503	Length:	2055	Species:	Homo sapiens

Alignment Length:	943	Identity:	174/943 - (18%)
Similarity:	278/943 - (29%)	Gaps:	340/943 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LLEVAR-RGAKFGML----------APMLVQMERQIDREIAADIKANGAGCS---ENGTQTDALE 201
            ||:.|. ||...|.|          ...|.:.:|:|.::..:|:.|:.||..   |:..|.:.|.
Human   214 LLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLS 278

  Fly   202 TGNS------SAATMTTITTTTV------------------------ETDLYDDSDDSETEDDGD 236
            ...|      ....|..:....|                        ||.|....|....:::.|
Human   279 QEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEAD 343

  Fly   237 ----------QNPVLMYGPQP------------------------QIITNDLKSLDEMVRDLVEK 267
                      .|....|.|.|                        :..|.||:.....|..|.::
Human   344 SVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQR 408

  Fly   268 CTCPSQFPM------------VRVSEG-KYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDK 319
            ...|.| |:            |::.:| :|::.|.        ...|..|..|.|.:|      |
Human   409 RNPPQQ-PLHVDSICDWDSGEVQLLQGERYKLVDN--------TDPHAWVVQGPGGET------K 458

  Fly   320 HDPCRC------------RA-----------QHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFE 361
            ..|..|            ||           |..::|.:||                 ||..:..
Human   459 RAPAACFCIPAPDPDAVARASRLASELQALKQKLATVQSRL-----------------KASAVES 506

  Fly   362 RSPPAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTPQ-RKFLN 425
            ..|       :.....||||.| .||.......: ||..:|..|:           .|| :|.|.
Human   507 LRP-------SQQGTQGGPGRG-GCGARRSRFRL-PTAPSGSDLA-----------NPQAQKLLT 551

  Fly   426 QQANGGG---------IASATGS-SQTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSL 480
            |.....|         :|.|... |:....:...|::......|:|..|....:....::.::.|
Human   552 QMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFL 616

  Fly   481 DSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDE 545
            .:...||.:|.              :..|...|.               |||.::.
Human   617 STRPVGPAALQ--------------LPVALNSVK---------------NKFSDVQ--------- 643

  Fly   546 GYRSLGVIQS--GAQKRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTDILEE--ED 606
                  |:.|  |.:.:.:|..:..|:||:   |:.:....:.:..:..|||...   |:|  .:
Human   644 ------VLCSLYGEKAKAALDLERQIQDAD---RVIRGFEATLVQEAPIPAEPGA---LQERVSE 696

  Fly   607 LNGQDREEDQEDYSV------------------------CDGPQSLPAILSGAHKLSDKFEQSGV 647
            |..|.||..::...|                        |   |.||........|:|::...|.
Human   697 LQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFC---QDLPRQQRQVRALTDRYHAVGD 758

  Fly   648 FITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSPL--------------AQRR------RRS 692
            .:...|..|..|....|...|...|.:..|..:|||.:              ||:|      .|.
Human   759 QLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRE 823

  Fly   693 IDNSTCGGAGGSLQ---------------DLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATT-TP 741
            .|.:|......:||               .|.....:.||...|..|:..|::.:....|.. |.
Human   824 RDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTE 888

  Fly   742 VAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGKGRSSQI 806
            ||..:.:...||...|.:...   :......||      |..|......||.:      ||.|:.
Human   889 VAAAQQQLLQQLEFARKMLEK---KELSEDIRR------THDAKQGSESPAQA------GRESEA 938

  Fly   807 L---YDSNGRRVRSGAPGCTSSLTTSPVKNHASSPLAQQLLEAASSAK----NDAQILE-----K 859
            |   .:...:||..              ..|.......|||:..:...    .:.:::|     :
Human   939 LKAQLEEERKRVAR--------------VQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQ 989

  Fly   860 MKSLLSRYAA----GNQTKAGVGA-TATAANKI 887
            ::..|||..|    ..:.:||:.| ...||.|:
Human   990 LEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKV 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981	4/8 (50%)
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	16/79 (20%)
EVPL	NP_001307676.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		4 X 4 AA tandem repeats of K-G-S-P	12..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..85
		SPEC	228..415	CDD:238103	30/187 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..418		8/30 (27%)
		Central fibrous rod domain	864..1695		37/188 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	913..938		9/36 (25%)
		Smc	934..1698	CDD:224117	20/103 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1658
		Globular 2	1696..2055
		Plectin	<1710..1740	CDD:279071
		PLEC	1840..1877	CDD:197605
		Plectin	1879..1920	CDD:279071
		PLEC	1916..1953	CDD:197605
		Plectin	1957..1996	CDD:279071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900