DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pigs and Plec

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001157012.1	Gene:	Plec / 18810	MGIID:	1277961	Length:	4691	Species:	Mus musculus

Alignment Length:	425	Identity:	91/425 - (21%)
Similarity:	149/425 - (35%)	Gaps:	112/425 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 IASATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSM 497
            |:|:.|..:::..|..||:.........::       |||    :|:||.|.:|..|:..:: .|
Mouse  4327 ISSSDGVVKSMIIDRRSGRQYDIDDAITKN-------LID----RSALDQYRAGTLSITEFA-DM 4379

  Fly   498 EEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKR-- 560
            ...|.|   |..:...|.||:.|......|...:..:.||...|.....    |::.:...::
Mouse  4380 LSGNAG---GFRSRSSSVGSSSSYPISSAGPRTQLASWSDPTEETGPVA----GILDTETLEKVS 4437

  Fly   561 --ESLHSQASIEDAESNARL--DQTSSDSQISPS-------DEPAEKATTDILEEEDLNGQDRE- 613
              |::|  .::.|..:..||  .|..:...|.||       .|...|...|.:..:.:|...:.
Mouse  4438 ITEAMH--RNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAF 4500

  Fly   614 ---EDQEDYSVCDGPQSLPA----ILSGAHKLSDKFEQSGVFITD--DEITVDIA---KTEDQSV 666
               ||....:.....|:|..    ..:|...|..::...|:...|  ..:::|.|   .|.|...
Mouse  4501 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDART 4565

  Fly   667 ANTMGNPTPNLSK---IPRSPLAQRRRRSIDNSTC-GGAGGSLQDLSSRS--GLPAPAFSRKQPV 725
            |..:.:.:. .||   .|::.|....:.::|.|.. .|.|..|.:.:::|  |..:|
Mouse  4566 AQKLRDVSA-YSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSP-------- 4621

  Fly   726 YRSVRTRNSTGATTTPVAPPRSRQATQLPMVRDVTNTWSGRTTG--APKRRPPCTADTFVAPTNG 788
             .||....||..:.|                        |..||  |..||
Mouse  4622 -YSVSGSGSTAGSRT------------------------GSRTGSRAGSRR-------------- 4647

  Fly   789 TGPAGSFERNGKGRS---SQILYDSN--GRRVRSG 818
                |||:..|.|.|   |...|.|:  |||..||
Mouse  4648 ----GSFDATGSGFSMTFSSSSYSSSGYGRRYASG 4678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981
pigs	NP_001245550.1	GAS2	258..325	CDD:280367
Plec	NP_001157012.1	Globular 1. /evidence=ECO:0000250	1..1478
		S10_plectin	7..101	CDD:281497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..186
		Actin-binding	181..411
		CH	186..293	CDD:237981
		CH	308..406	CDD:278723
		SPEC	667..761	CDD:197544
		SPEC	763..941	CDD:238103
		SPEC	1247..1437	CDD:238103
		Central fibrous rod domain. /evidence=ECO:0000250	1479..2762
		GBP_C	<1497..1598	CDD:303769
		Myosin_tail_1	1526..2713	CDD:279860
		coiled coil	1588..1598	CDD:293879
		ATP-synt_B	<1620..1743	CDD:304375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1626..1653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1801..1835
		SPEC	1871..2046	CDD:295325
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2100..2141
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2223..2317
		GBP_C	<2326..2510	CDD:303769
		coiled coil	2477..2490	CDD:293879
		coiled coil	2499..2510	CDD:293879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2675..2728
		Globular 2. /evidence=ECO:0000250	2763..4691		91/425 (21%)
		Plectin	2834..2875	CDD:279071
		Plectin	2873..2913	CDD:279071
		PLEC	2910..2946	CDD:197605
		Plectin	2948..2989	CDD:279071
		Plectin	3164..3203	CDD:279071
		Plectin	3201..3241	CDD:279071
		PLEC	3238..3274	CDD:197605
		Plectin	3276..3315	CDD:279071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3312..3338
		Plectin	3494..3534	CDD:279071
		Plectin	3532..3572	CDD:279071
		PLEC	3569..3600	CDD:197605
		Plectin	3607..3648	CDD:279071
		Plectin	3828..3869	CDD:279071
		Plectin	3867..3907	CDD:279071
		PLEC	3904..3940	CDD:197605
		Plectin	3942..3983	CDD:279071
		Plectin	4071..4112	CDD:279071
		Plectin	4110..4150	CDD:279071
		Plectin	4185..4226	CDD:279071
		Binding to intermediate filaments. /evidence=ECO:0000250	4257..4307
		Plectin	<4287..4317	CDD:279071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4387..4420		7/32 (22%)
		PLEC	4419..4452	CDD:197605	5/38 (13%)
		Plectin	4454..4493	CDD:279071	9/38 (24%)
		Plectin	4530..4571	CDD:279071	8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4618..4691		26/112 (23%)
		4 X 4 AA tandem repeats of G-S-R-X	4632..4647		5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900