DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pigs and eppk1

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001313413.1	Gene:	eppk1 / 101885652	ZFINID:	ZDB-GENE-030416-1	Length:	5476	Species:	Danio rerio

Alignment Length:	554	Identity:	107/554 - (19%)
Similarity:	184/554 - (33%)	Gaps:	153/554 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 MTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVEKCTCPSQF 274
            :.||.|||:|| |.....:|:| ..|.:.||            .:|.|.|  ..:::..|
Zfish  1161 VVTIVTTTIET-LEQKEANSQT-TMGLRKPV------------SVKQLHE--SGIIDTTT----- 1204

  Fly   275 PMVRVSEGKYRIGD----TKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAA 335
             ..::..||..:.:    ..|..:::..||...|::......||.|..|:|     ....:.||.
Zfish  1205 -YKQLQNGKETLENMLKLESVQKYLKGTRSIAGVKLHPSGKVLSVYKAKND-----GLLTADVAL 1263

  Fly   336 RLIPRQS-------PNHNPSNGI-ELHKAQV----IFERSPPAARRV--FNSPNCNGGPGTGSSC 386
            .|:..|:       |..|..:.: |..|||:    |.|....|.|.|  |..|..|.......:.
Zfish  1264 SLLEAQAATGYVIDPIKNTHHSVLEAVKAQLIGPEILEHLLLAERAVTGFTDPYTNEQICLFEAM 1328

  Fly   387 GTGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTPQRK---FLNQQANGGGIASATGSSQT-VTTDT 447
            ..|::                           ||::   .|:.|...|||....||.:. |....
Zfish  1329 KKGLI---------------------------PQKQGQNLLHAQLATGGIVDPIGSHRVPVQIAI 1366

  Fly   448 SSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGG 512
            ..|.|....:....::..|.....|.:.|:..            .||..|.:....|........
Zfish  1367 KQGFLSKETNDLLANIGKSENGFSDPQTKEPL------------NYSQLMSKCERDSTTSLLLLP 1419

  Fly   513 VSSGSAGSGVAGEQGGANKF--ENISDNGSEISDEGYRSLGVIQS---GAQKRESL-----HSQA 567
            |:..:|.|....|:...|.|  :::..|..:.:|:.......:.|   .|:||:.|     .::.
Zfish  1420 VTENNAESSAYNEEQILNVFKEKSVITNAGKFADKRVSLWDALNSEYISAEKRKELLDQYKQNKL 1484

  Fly   568 SIEDAE----------SNARLDQTSSDSQISPSD---------EPAEKATTDILEEEDLNGQDRE 613
            |||:..          :..|........|:|.|:         |...|...:.:::||:|..
Zfish  1485 SIEEITQIVTAIIIEVTTKRHSFKGLRRQVSASELFEAKIISKEMIGKLINNEVDDEDINNM--- 1546

  Fly   614 EDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEITVDIAKTEDQSVANTMGNPTPNLS 678
                        :|:...|...:.:      :|||:...:.|:.|.:      |...|..||..|
Zfish  1547 ------------ESIQKYLGATNCI------AGVFVQSTKQTMSIFE------AKNKGLLTPGTS 1587

  Fly   679 KIPRSPLA---------QRRRRSIDNSTCGGAGG 703
            .:.....|         :.::.|::.:...|..|
Zfish  1588 LVLLEAQAATGFVIDPVKNKKLSVEQAVAEGIVG 1621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	13/70 (19%)
eppk1	NP_001313413.1	Plectin	4263..4304	CDD:279071
		Plectin	4302..4342	CDD:279071
		PLEC	4339..4375	CDD:197605
		Plectin	4377..4418	CDD:279071
		Plectin	4602..4643	CDD:279071
		Plectin	4641..4681	CDD:279071
		PLEC	4678..4714	CDD:197605
		Plectin	4716..4757	CDD:279071
		Plectin	4941..4982	CDD:279071
		Plectin	4980..5020	CDD:279071
		PLEC	5017..5053	CDD:197605
		Plectin	5055..5096	CDD:279071
		Plectin	5280..5321	CDD:279071
		Plectin	5319..5359	CDD:279071
		PLEC	5356..5392	CDD:197605
		Plectin	5394..5435	CDD:279071
		Plectin	42..81	CDD:279071
		PLEC	79..113	CDD:197605
		Plectin	117..154	CDD:279071
		Plectin	243..283	CDD:279071
		Plectin	281..320	CDD:279071
		PLEC	317..354	CDD:197605
		Plectin	356..397	CDD:279071
		Plectin	607..647	CDD:279071
		PLEC	648..675	CDD:197605
		Plectin	682..723	CDD:279071
		Plectin	895..935	CDD:279071
		Plectin	933..972	CDD:279071
		PLEC	970..1001	CDD:197605
		Plectin	1008..1049	CDD:279071
		Plectin	1265..1304	CDD:279071	10/38 (26%)
		PLEC	1302..1333	CDD:197605	7/30 (23%)
		Plectin	1341..1379	CDD:279071	10/37 (27%)
		Plectin	1551..1592	CDD:279071	11/52 (21%)
		Plectin	1590..1630	CDD:279071	4/32 (13%)
		PLEC	1627..1663	CDD:197605
		Plectin	1665..1706	CDD:279071
		Plectin	1890..1931	CDD:279071
		Plectin	1929..1969	CDD:279071
		PLEC	1966..2002	CDD:197605
		Plectin	2004..2045	CDD:279071
		Plectin	2229..2270	CDD:279071
		Plectin	2268..2308	CDD:279071
		PLEC	2305..2341	CDD:197605
		Plectin	2343..2384	CDD:279071
		Plectin	2568..2609	CDD:279071
		Plectin	2607..2647	CDD:279071
		PLEC	2644..2680	CDD:197605
		Plectin	2682..2723	CDD:279071
		Plectin	2907..2948	CDD:279071
		Plectin	2946..2986	CDD:279071
		PLEC	2983..3019	CDD:197605
		Plectin	3021..3062	CDD:279071
		Plectin	3246..3287	CDD:279071
		Plectin	3285..3325	CDD:279071
		PLEC	3322..3358	CDD:197605
		Plectin	3360..3401	CDD:279071
		Plectin	3585..3626	CDD:279071
		Plectin	3624..3664	CDD:279071
		PLEC	3661..3697	CDD:197605
		Plectin	3699..3740	CDD:279071
		Plectin	3924..3965	CDD:279071
		Plectin	3963..4003	CDD:279071
		PLEC	4000..4036	CDD:197605
Plectin	4038..4079	CDD:279071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900