DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pigs and plecb

DIOPT Version :9

Sequence 1:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_021322489.1	Gene:	plecb / 100321011	ZFINID:	ZDB-GENE-100917-2	Length:	5908	Species:	Danio rerio

Alignment Length:	842	Identity:	153/842 - (18%)
Similarity:	253/842 - (30%)	Gaps:	301/842 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQ-VIFERSPPAA 367
            ::..|.|:  |..|......|...:.....|.|.:...|.:|      |.|.|: |..||.....
Zfish   174 IKPKGSWE--SKELPIRSDNRDYTKEMEPSARRKVAMHSFSH------ETHHAKPVEQERMVECT 230

  Fly   368 RRVFNSPNCNGGPGTGSSCGTGVVGVAVP---------------------PTLQNGHSLSPNSGK 411
            :..|........||..:.....|....||                     .|.:..|..:|:..|
Zfish   231 KTAFIQDMPKASPGVLTISSAAVESPLVPVHSEAIKEKPKVDVSRQSTSITTAKEAHHPTPSKLK 295

  Fly   412 YRSRSPTPQRKFLNQQANGGGIASATGSSQTV-----------------------TTDTSSGQLL 453
            ..........:.::...|   :|||   .:|:                       ||.|::|.|.
Zfish   296 VEKTEKALVSRKMDHVPN---VASA---EETIALESFVHAQENPKEEEFTKVTKQTTSTTTGALR 354

  Fly   454 GSPS------------------LARRSMSP-------------------SPRRLIDMRKKQSSLD 481
            .:||                  ::..|..|                   |.:..:....|.:..|
Zfish   355 ATPSKPKVDKTQETMVAKNELDVSNESSKPPVSIEAAKTKPKQDVCIKVSEKTTVVNASKMAEGD 419

  Fly   482 SY--SSGPK-----SLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNG 539
            ::  |||||     ::|..|.::|       :.:....|||
Zfish   420 AHLTSSGPKVDKSNNVPAVSAALE-------ISAFKSSVSS------------------------ 453

  Fly   540 SEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTDILEE 604
              :|.|..:.:       .|.||..|:......:|||    .|..||:....|..:|||
Zfish   454 --VSTEAIKEI-------PKEESCVSKEITSKGDSNA----ASHHSQLKTKGEKRQKAT------ 499

  Fly   605 EDLNGQDREEDQEDYSVCDGPQSLPAIL--SGAHKLSDKFEQSGVFITDDEITVDIAKTEDQSVA 667
                   :.:..:| |.|..|....:::  ||:..:.:|        |::|:.|   |...||..
Zfish   500 -------KTKSVQD-STCVPPAEEMSVVKPSGSEAVKEK--------TEEEVCV---KLSQQSAL 545

  Fly   668 NTMGN-----PTPNLSKIPRSPLAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPVYR 727
            ...|.     |.|.:|. |:...||:.|::          ..:|||...|.....:...::|
Zfish   546 KGEGGIEKDAPHPTVSS-PQVEKAQKTRKN----------KKVQDLPMFSSTVQSSEKAEKP--- 596

  Fly   728 SVRTRNSTGAT---TTPVAPPRSRQATQLPMVRDVTNTWSGRTT-----GAPKRRPPCTADTFVA 784
              :...||..|   |.||. ..|:.|...|....|..|.....|     |...:.|.|:.....|
Zfish   597 --KDDESTKVTKEITLPVT-DESKMAIDAPHPTHVEKTVKTIVTKNVQDGTSLKSPVCSVPAETA 658

  Fly   785 PTNGTGPAGSFERNGK---GRSSQILYDSNGRRVRSGAP-------------------------- 820
            .          |::.|   |..||.....:..:....||
Zfish   659 N----------EKSNKEVCGIVSQETSSKDDNKTAFSAPSKSKVGKTATRIKNVQDKPAISSAVE 713

  Fly   821 -----GCTSSLTTSPV----------------------KNHA-SSPLAQQLLEAASSAK------ 851
                 ..|.||:|..:                      ||:| .|..:.|.:|...:.|
Zfish   714 TTVVASSTFSLSTETIKEQYKEKVCVIASQETPFKGDKKNYAFHSATSTQKMEKMQTTKTAQTKP 778

  Fly   852 --NDAQILEKMKSLLSRYAAGNQTKAGVGATATAANKINSNGKKTPVYEDFTTAWVHSNGNLERS 914
              :.|:.:.::||.:|..|...::|..||...|.....|.:.||..::
Zfish   779 AVSSAEEMMEVKSSMSTEAVNEKSKREVGGIVTQETTSNGDNKKDALH----------------- 826

  Fly   915 ESCSPPAKARSKRSSAASSCESNNSNAGAGSGAAAGSASVVSPRRERGMSKIPAPVRHHTEL 976
                 ||.::||......|..:::|...:....|...::::|...|:...::...|...|.|
Zfish   827 -----PAVSKSKVVKILESKNAHDSTVVSSWMEAEVKSTLISTDAEKPKEEVCLMVSQETTL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pigs	NP_001245550.1	CH	22..159	CDD:237981
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	4/20 (20%)
plecb	XP_021322489.1	S10_plectin	7..99	CDD:308874
		COG3942	439..>726	CDD:332523	73/382 (19%)
		Spr	<943..>1241	CDD:333284
		SAC6	1414..>1657	CDD:227401
		SPEC	1922..2016	CDD:197544
		SPEC	2017..2198	CDD:238103
		NBD94	<2325..>2999	CDD:330409
		Neuromodulin_N	<2680..3484	CDD:331332
		Neuromodulin_N	<3187..3978	CDD:331332
		Plectin	4117..4157	CDD:307019
		Plectin	4193..4233	CDD:307019
		Plectin	4445..4484	CDD:307019
		Plectin	4520..4560	CDD:307019
		PLEC	4737..4773	CDD:197605
		Plectin	4776..4815	CDD:307019
		PLEC	4813..4844	CDD:197605
		Plectin	4851..4890	CDD:307019
		Plectin	5103..5142	CDD:307019
		PLEC	5140..5174	CDD:197605
		Plectin	5178..5218	CDD:307019
		Plectin	5303..5343	CDD:307019
		Plectin	5342..5381	CDD:307019
		PLEC	5379..5415	CDD:197605
		Plectin	5417..5456	CDD:307019
		Plectin	<5519..5548	CDD:307019
		PLEC	5652..5685	CDD:197605
		Plectin	5687..5726	CDD:307019
		Plectin	5763..5802	CDD:307019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900