DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and Ddx50

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_444413.1	Gene:	Ddx50 / 94213	MGIID:	2182303	Length:	734	Species:	Mus musculus

Alignment Length:	598	Identity:	121/598 - (20%)
Similarity:	232/598 - (38%)	Gaps:	146/598 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 KTSRENKESRSRSSSLPQKRFCPSKTQNDLT--YGSPEPKSPSNRGR--NSWRVGMR-----TPW 244
            :.||.:.||..|:.:          .:|.:|  ..:|:||....|.:  ...:.|:|     :|.
Mouse    33 RKSRHHSESEERTET----------RENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPS 87

  Fly   245 KKSQSRSMSCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANY 309
            .||:.:.:....:.:                   |:.:||..|...|.:......:|
Mouse    88 HKSRRKDLPNGDVDE-------------------YEKRSKRVSSSENSHKSSDKAEE-------- 125

  Fly   310 RKRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMIS 374
                  |||    |...|.  :|.....:...::.|:.:|.....|||.:|:....|||:::..:
Mouse   126 ------TLT----REQKEG--AFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQA 178

  Fly   375 GKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLL 439
            ..|||||..:.:|.|.::...:..::..:.|.||:|...||.|..|.::....|..|.:.  |..
Mouse   179 RTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVA--CFY 241

  Fly   440 GNSQWQGHAE-----CDLLVASAGRLLQMIDNKKHV----VELERCTYLVLDNIDRMIDVGLEGN 495
            |.:.:|....     .|:||.:.||:      |.|:    ::|.:..::|||.:|:|:|:|....
Mouse   242 GGTSYQSQINQIRNGIDILVGTPGRI------KDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQ 300

  Fly   496 ICRLLCRLRPHAQLIVSSTS------WSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVE 554
            :..::     |......|..      :|:...:...|...:|...|..:::.:|...|.....||
Mouse   301 VEDII-----HESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVE 360

  Fly   555 ---VVNGLSKVERLMKELTAIYDTSDIPGKVVIYVKRQKVVEELV--DLIRNCVPCEGIHGGRTA 614
               :....|:...::.::..:|..|:  |:.:|:.:.:|.|.|:.  ..|:....|  :||....
Mouse   361 HLAIQCHWSQRPAVIGDVLQVYSGSE--GRAIIFCETKKNVTEMAMNPHIKQNAQC--LHGDIAQ 421

  Fly   615 QENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG-------CL 672
            .:.:..:..|..|::.::|||.:.:..||:|.:..||....|.:::.|:.|..|||       |:
Mouse   422 SQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICV 486

  Fly   673 SY---------------------------------NRNCEVISFFTMANYKLVTEVVDFLKICKQ 704
            .:                                 :::.:.|......:|    ..|||.:
Mouse   487 CFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSY----AAVDFFR---- 543

  Fly   705 EIGPHLLQLAEEK 717
               |...:|.|||
Mouse   544 ---PSAQRLIEEK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	50/217 (23%)
		DEXDc	345..544	CDD:214692	50/213 (23%)
		Helicase_C	560..670	CDD:278689	26/111 (23%)
Ddx50	NP_444413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		26/144 (18%)
		SrmB	130..608	CDD:223587	95/454 (21%)
		Q motif	134..162		5/29 (17%)
		DEADc	136..339	CDD:238167	50/215 (23%)
		DEVD box	287..290		1/2 (50%)
		HELICc	369..486	CDD:238034	28/120 (23%)
		GUCT_RHII_Gualpha_beta	565..656	CDD:240593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..734
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910