Protein Alignment CG14443 and TDRD12

DIOPT Version :9

• Sequence 1: NP_572330.2
• Gene: CG14443 / 31595
• FlyBaseID: FBgn0029880
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_011525773.1
• Gene: TDRD12 / 91646
• HGNCID: 25044
• Length: 1335
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 118/635 - (18%)
• Similarity: 224/635 - (35%)
• Gaps: 187/635 - (29%)

  Fly   186 KAVKTSRENKESRSRSSSLPQKRFC----------------PSKTQNDLTYGSPEPKSPSNRGRN 234
            ||||.:.::.....:..| .:|..|                |:| :....|..|:....|...:.
Human   290 KAVKCNMDSLRDSPKDKS-EKKHHCISLKDTNKRVESSVYWPAK-RGITIYADPDVPEASALSQK 352

  Fly   235 SWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPM 299
            |....:|...||......||..:.:.|                     :.:|.|....:..:|
Human   353 SNEKPLRLTEKKEYDEKNSCVKLLQFL---------------------NPDPLRADGISDLQQ-- 394

  Fly   300 DEVYNNAANYRKRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIA 364
                     .:|...:......:||..:|.|:.:.|..:|.:.:.|:...:.||:..::.:|...
Human   395 ---------LQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPI 450

  Fly   365 KEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGL----MQHKKGPIVLILVDCREAAVMVQR--- 422
            ..|.::|:||...:...| ||||.:..:  |.|.    :..:.||:.:|:....:.|..:..
Human   451 ARGCDVVVISHCESNPLL-YLLPVLTVL--QTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLG 512

  Fly   423 EVLYYTNPLE--LRTHCLLGNSQWQGHAE----------CDLLVASAGRLLQMIDNKK------- 468
            |....:.||.  |.|..|        |.|          ||::|.:...||:::..:.
Human   513 EYSMSSRPLHPVLLTIGL--------HKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFLRLC 569

  Fly   469 HVV---------ELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMA 524
            |::         |.....:.:|||..:.|:|....:        .|| |::.....|:.:::.:.
Human   570 HLILDEVEVLFLEANEQMFAILDNFKKNIEVEERES--------APH-QIVAVGVHWNKHIEHLI 625

  Fly   525 NKFLGQ-YTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVERLMKEL---------TAIYDTSDIP 579
            .:|:.. |..|...|   ......|::|.|.:.....|...|::.|         |.|:..|...
Human   626 KEFMNDPYIVITAME---EAALYGNVQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAE 687

  Fly   580 GKVVIYVKRQKVVEELVDLIRNCVPCEGIHGGRTAQEN----QGIIHDF----GTGAYNIIVATQ 636
            .::|.     ||||.      :.:.|..:|     :|.    |.::..:    .:|: .||:|
Human   688 TEIVC-----KVVES------SSIFCLKMH-----KEMIFNLQNVLEQWKKKLSSGS-QIILA-- 733

  Fly   637 MTSNC---LDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCE------------------- 679
            :|.:|   |.:.....||::.||.:...:..|:.   |:|.:.:.|
Human   734 LTDDCVPLLAITDATCVIHFSFPASPKVFGGRLY---CMSDHFHAEQGSPAEQGDKKAKSVLLLT 795

  Fly   680 ---------VISFFTMANYKLVTEVVDFLKICKQEIGPHLLQLAEEKMFG 720
                     |:.:...|:.|:..|:.:|.        ..:|:..|:|..|
Human   796 EKDASHAVGVLRYLERADAKVPAELYEFT--------AGVLEAKEDKKAG 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	47/238 (20%)
		DEXDc	345..544	CDD:214692	47/234 (20%)
		Helicase_C	560..670	CDD:278689	27/129 (21%)
TDRD12	XP_011525773.1	TUDOR	10..128	CDD:278965
		TUDOR	60..109	CDD:119391
		P-loop_NTPase	419..635	CDD:304359	47/235 (20%)
		SrmB	422..881	CDD:223587	90/469 (19%)
		P-loop_NTPase	659..762	CDD:304359	26/121 (21%)
		TUDOR	<913..1004	CDD:278965
		alpha-crystallin-Hsps_p23-like	1193..1297	CDD:294116

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900