DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and Recql4

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_006521609.1	Gene:	Recql4 / 79456	MGIID:	1931028	Length:	1267	Species:	Mus musculus

Alignment Length:	743	Identity:	149/743 - (20%)
Similarity:	250/743 - (33%)	Gaps:	202/743 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GQSRSLKSSSSVLSSKFVTKRLFTIQHG------------------------IEGQKPNFK---- 82
            ||.:.|:||        :::||.::..|                        .|..:|...
Mouse   171 GQLQQLRSS--------LSRRLTSLDPGWLERCHNRVSDLLEVPGACGLDLSAEESQPQMSGKVN 227

  Fly    83 -----IRSE-SFSGPHS-----AGGFSKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSSGSES 136
                 |:|| |...|.:     |...|:|.:...||.|.            |..:|    .|.:.
Mouse   228 IADPDIQSEVSVQSPEAIAQQPAQVLSQSPKSINSKGRK------------RKWNE----KGEDF 276

  Fly   137 SSSDSNSGSSSDSDSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRS 201
            :....:||:...|:... ::.||.|....|...:..       |..||....:|.:....:...:
Mouse   277 AQDQPSSGAGPLSEGAR-ATVHGQDPPGEPTQVNVP-------QPCNSSNQARTEKAKGTTHLHA 333

  Fly   202 SSLP--------------QKRFCPSKTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSM 252
            |..|              .|||.               :..:||||...:...:..|||.|: :.
Mouse   334 SPRPASLDRGNYIRLNMKNKRFV---------------RVGANRGRLLRKQVWKQKWKKKQA-AF 382

  Fly   253 SCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQP---MDEVYNNAANYRKRHN 314
            ..|..:.......|...:..|..:.|.|.......:.......|||   ::||..........|:
Mouse   383 GGSGPRATDKDTCFRCGQFGHWASQCSQPGPTLTVQEEGDRDDKQPISTLEEVAQRTGTASCHHS 447

  Fly   315 I------TLTSWNMRNLPEPVLSFERSG-------FNATILQQLEDQGYDGPTPIQAQTWSIAKE 366
            .      ......:.:.|.|:......|       ..|.:.|.||..||....|.|.:.......
Mouse   448 AGEETQPAAPELQVPHCPTPMSPLYPPGPLGQVAETPAEVFQALERLGYRAFRPGQERAIMRILS 512

  Fly   367 GKNIVMISGKGTGKTLGYLLPGIMKMHNQRG-LMQHKKGPIVLILVD-------CREAAVM---- 419
            |.:.:::...|.||:|.|.||.:  ::.||. .:.....|::.::.|       |.:||.:
Mouse   513 GISTLLVLPTGAGKSLCYQLPAL--LYAQRSPCLTLVVSPLLSLMDDQVSDLPSCLKAACLHSGM 575

  Fly   420 --VQRE-VLYYTNPLELRTHCLLGNSQWQGHAECDLLVA----SAGRLLQMIDNKKHVVELERCT 477
              .||| ||......::  |.|:        ...:.||.    ..|.|.|       ..:|....
Mouse   576 TKKQRESVLKKVRAAQV--HVLI--------VSPEALVGCGARGPGSLPQ-------AAQLPPIA 623

  Fly   478 YLVLDNIDRMIDVGLEGNICRL-LCR-LRPH----AQLIVSSTSWSSNLKRMANKFLGQYTAIRV 536
            :..:|.:..:.........|.| :|: ||.|    ..|.:::|:..|..:.:|     |:..| .
Mouse   624 FACIDEVHCLSQWSHNFRPCYLRVCKVLREHMGVRCFLGLTATATRSTARDVA-----QHLGI-A 682

  Fly   537 GEIN---------NIGVRLQNIRQRVEVVNGLSKVERLMKELTAIYDTSDIPGKVVIYVKRQKVV 592
            ||..         |:.:.:...|...:.:..|.:.:|        :.|.|   .|:||..|:|..
Mouse   683 GEFELSGSANIPANLHLSVSMDRDSDQALVTLLQGDR--------FRTLD---SVIIYCTRRKDT 736

  Fly   593 EELVDLIRNCVP---------------CEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCL 642
            |.:..|:|.|:.               .|..|.|.::||.:.:...|..|...::|||......|
Mouse   737 ERVAALLRTCLSMVGDSRPRGCGPEAIAEAYHAGMSSQERRRVQQAFMRGHLRMVVATVAFGMGL 801

  Fly   643 DVPGIRYVINYDFPDNIDKYVQRMSRTG 670
            |.|.:|.|::...|.:.:.|||.:.|.|
Mouse   802 DRPDVRAVLHLGLPPSFESYVQAIGRAG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	49/234 (21%)
		DEXDc	345..544	CDD:214692	50/232 (22%)
		Helicase_C	560..670	CDD:278689	32/124 (26%)
Recql4	XP_006521609.1	Drc1-Sld2	4..>49	CDD:371692
		ZnF_C2HC	394..408	CDD:197667	2/13 (15%)
		RecQ	483..>844	CDD:223588	87/383 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4803
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950