DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and DDX50

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_076950.1	Gene:	DDX50 / 79009	HGNCID:	17906	Length:	737	Species:	Homo sapiens

Alignment Length:	605	Identity:	122/605 - (20%)
Similarity:	233/605 - (38%)	Gaps:	140/605 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 VKTSRENKESRSRSSSLPQKRFCPS-----KTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKS 247
            ::.|...|:.|.:|.....:....|     ..:|.:|.....||:                 |||
Human    17 LEESESQKKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKA-----------------KKS 64

  Fly   248 QSRSMSCSSIQKIL--VSRSFTRSRSPHRNTLC------YQDQSKNPSR--PSNYNTWKQPMDEV 302
            :.:.......::..  :|..|::|....|..|.      |:.:||..|.  .|.:.:....::|
Human    65 KMKEKLNGDTEEGFNRLSDEFSKSHKSRRKDLPNGDIDEYEKKSKRVSSLDTSTHKSSDNKLEE- 128

  Fly   303 YNNAANYRKRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEG 367
                         |||    |...|.  :|.....:...::.|:.:|.....|||.:|:....||
Human   129 -------------TLT----REQKEG--AFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEG 174

  Fly   368 KNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLE 432
            |:::..:..|||||..:.:|.|.::...:..::..:.|.||:|...||.|..|.::....|..|.
Human   175 KDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLS 239

  Fly   433 LRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKHV----VELERCTYLVLDNIDRMI 488
            :.  |..|.:.:|....     .|:||.:.||:      |.|:    ::|.:..::|||.:|:|:
Human   240 VA--CFYGGTSYQSQINHIRNGIDILVGTPGRI------KDHLQSGRLDLSKLRHVVLDEVDQML 296

  Fly   489 DVGLEGNICRLLCRLRPHAQLIVSSTS------WSSNLKRMANKFLGQYTAIRVGEINNIGVRLQ 547
            |:|....:..::     |......|..      :|:...:...|...:|...|..:::.:|...|
Human   297 DLGFAEQVEDII-----HESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQ 356

  Fly   548 NIRQRVE---VVNGLSKVERLMKELTAIYDTSDIPGKVVIYVKRQKVVEELV--DLIRNCVPCEG 607
            .....||   :....|:...::.::..:|..|:  |:.:|:.:.:|.|.|:.  ..|:....|
Human   357 KAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSE--GRAIIFCETKKNVTEMAMNPHIKQNAQC-- 417

  Fly   608 IHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG-- 670
            :||.....:.:..:..|..|::.::|||.:.:..||:|.:..||....|.:::.|:.|..|||
Human   418 LHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRA 482

  Fly   671 -----CLSY---------------------------------NRNCEVISFFTMANYKLVTEVVD 697
                 |:.:                                 :::.:.|......:|    ..||
Human   483 GRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSY----AAVD 543

  Fly   698 FLKICKQEIGPHLLQLAEEK 717
            |.:       |...:|.|||
Human   544 FFR-------PSAQRLIEEK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	50/217 (23%)
		DEXDc	345..544	CDD:214692	50/213 (23%)
		Helicase_C	560..670	CDD:278689	26/111 (23%)
DDX50	NP_076950.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		24/144 (17%)
		SrmB	108..526	CDD:223587	94/454 (21%)
		Q motif	137..165		5/29 (17%)
		DEADc_DDX21_DDX50	148..349	CDD:350702	50/213 (23%)
		DEVD box	290..293		1/2 (50%)
		GUCT_RHII_Gualpha_beta	568..659	CDD:240593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..737
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910