DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and ddx21

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001039224.1	Gene:	ddx21 / 734085	XenbaseID:	XB-GENE-1012547	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	141/712 - (19%)
Similarity:	248/712 - (34%)	Gaps:	212/712 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKAKKLVIGNWKDNETDAEKVQKKPFLKGTKSSIWGSSASDISGQSRSLKSSSSVLSSKFVTKRL 67
            |..||.     |.:||...|::|:....|....:      |:...:.|:...
Frog    13 ESVKKK-----KQSETPLPKIKKRKMQNGATEDL------DLEQVAESVNGE------------- 53

  Fly    68 FTIQHGIEGQKPNFKIRSESFSGPHSAGGFSKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSS 132
                  |....|..|::.:....|.|....:....|......|....|...|..|:...|
Frog    54 ------INNNNPTPKLKKKKKPVPQSDLSETAEQYEGEQPDPSTPIPKKVKKKKLKEGKE----- 107

  Fly   133 GSESSSSDSNSGSSSDSDSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKES 197
                           |||     :..|:|..| |:|              |..|:||.|::|
Frog   108 ---------------DSD-----TQEGTDKSE-PQM--------------NGVKSVKKSKKN--- 134

  Fly   198 RSRSSSLPQKRFCPSKTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSMSCSSIQKILV 262
                                 |.|.....:|..|.:::..:
Frog   135 ---------------------TTGDDNEPTPKKRKKDTMEI------------------------ 154

  Fly   263 SRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANYRKRHNITLTSWNMRNLPE 327
                |.|.......|..:::..|..:...
Frog   155 ----TASEECEEKQLTKEEEEINQEKIDG------------------------------------ 179

  Fly   328 PVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKM 392
               .|.:...:...::.|:.:|.....|||::|:..|..||::|:.:..|||||..:.:|.:.::
Frog   180 ---DFSKFPISKDTIKNLQAKGVSYLFPIQSKTFHTAYSGKDVVVQARTGTGKTFSFAIPLVERL 241

  Fly   393 HNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHA-----ECDL 452
            :..:..:...:.|.|:||...||.|:.:..|:...|.  :|:..|..|.:.:|...     ..|.
Frog   242 NEDQQPLARGRAPRVIILTPTRELAIQITNEIRSITK--KLKVCCFYGGTPYQQQVFSIKEGFDF 304

  Fly   453 LVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLL-CRLRPHAQ-----LIV 511
            ||.:.||:..::.|.:  ::|....::|||.:|.|.|:|....:..:| .|.:|..:     |:.
Frog   305 LVGTPGRVRDLVQNYR--LDLTVLKHVVLDEVDMMFDMGFSEQVEEILSVRYKPDPEENPQTLLF 367

  Fly   512 SST--SWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVE---VVNGLSKVERLMKELTA 571
            |:|  .|..|:.:       :|...:..:|:.:|.|.|.....||   :....|:...::.::..
Frog   368 SATCPDWMYNVAK-------KYMKKQFEKIDLVGHRSQKAAITVEHLAIECTRSQKAAVLGDIVQ 425

  Fly   572 IYDTSDIPGKVVIYVKRQKVVEELVDLIRNC----VPCEGIHGGRTAQENQGIIHDFGTGAYNII 632
            :|..|.  ||.:|:...:....||.   .||    ...:.:||....:|.:.|:..|..|::.::
Frog   426 VYSGSH--GKSIIFCDSKLEAHELA---TNCGSLKQSAKPLHGDLQQKEREVILKGFRQGSFEVL 485

  Fly   633 VATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG-------CLS--------YNRNCE 679
            |||.:.:..||:|.:..|:.|..|...|.||.|..|||       |:|        |.||.|
Frog   486 VATNVAARGLDIPEVDLVVLYSAPKEADAYVHRSGRTGRAGRTGICISLYEPRERHYLRNVE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	53/215 (25%)
		DEXDc	345..544	CDD:214692	53/211 (25%)
		Helicase_C	560..670	CDD:278689	30/113 (27%)
ddx21	NP_001039224.1	PRK01297	83..551	CDD:234938	125/612 (20%)
		DEADc	181..385	CDD:238167	53/214 (25%)
		HELICc	404..534	CDD:238034	35/134 (26%)
		GUCT_RHII_Gualpha_beta	611..703	CDD:240593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000