DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14443 and Ddx59

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_080776.1	Gene:	Ddx59 / 67997	MGIID:	1915247	Length:	619	Species:	Mus musculus

Alignment Length:	678	Identity:	154/678 - (22%)
Similarity:	284/678 - (41%)	Gaps:	124/678 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KSTRESRSKSRSMGNGKFRGKSHLRSSSES------------AHSSGSESSSSDSNSGSSSDSDS 151
            :|.:..||.:..:.:|:.:     :|..|:            .|:|.:|.:.:....|.:|.::|
Mouse     5 RSLKIKRSSNDDLKSGEAK-----KSKPEAGGLQVEGDRDTPVHTSVTEEAVTADKPGHASSTNS 64

  Fly   152 TTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRSSSLPQKRFCPSKTQN 216
            .:...:..|.||                  |:  :.||.|..::|        |.|.|  ||||.
Mouse    65 PSCQLAEVSSTG------------------PD--EGVKDSHPSEE--------PVKSF--SKTQR 99

  Fly   217 DLTYGSPEPKSP--SNRGRNSWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTRSRSPHRNTLCY 279
                 .|||..|  ...||....:..:|   .....|:.|.:...:.|...
Mouse   100 -----WPEPGEPVCVVCGRYGEYICDKT---DEDVCSLECKAKHLLQVKEG-------------- 142

  Fly   280 QDQSKNPSRPSNYNTW-KQPMDEVYNNAANYRKRHNITLT---------------SWNMRNLPEP 328
             :.|..||.|...... :.|:|..|     ..|.|...:|               |...:::..|
Mouse   143 -EGSLRPSSPQRVAAEPESPLDAFY-----VYKEHPFIVTLKEDQIETLKQQLGISVQGQDVARP 201

  Fly   329 VLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMH 393
            ::.||..||..|:.|.|:..||:.|||||.|...:...|::|:..:..|:|||..:|||.|::..
Mouse   202 IIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAF 266

  Fly   394 NQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPL-ELRTHCLLGN-----SQWQGHAECDL 452
            ::      .|.|..|||...||.|:.::|:.....:.| .::|..|:|.     ..::......:
Mouse   267 SE------DKTPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKV 325

  Fly   453 LVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWS 517
            ::|:.||||.:|  |:..|.|.....:|:|..|.|:.:|.:..:..:|.......|.|:.|.:..
Mouse   326 IIATPGRLLDII--KQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIP 388

  Fly   518 SNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVERLMKELTAIYDTSDIPGKV 582
            .:::::.::.|.....|..|:.|   :...::||.:..|...:|.::|.:.|.   |.......|
Mouse   389 DSIEQLTDQLLHNPVRIITGDKN---LPCASVRQIILWVEDPAKKKKLFEILN---DQKLFKPPV 447

  Fly   583 VIYVKRQKVVEELVDLIRNC--VPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVP 645
            :::|..:...:.|.:.::..  :....||..::..|.:.|:.....|.|.::|:|.:....||:.
Mouse   448 LVFVDCKLGADLLSEAVQKITGLNSTSIHSEKSQVERRDILKGLLEGDYEVVVSTGVLGRGLDLV 512

  Fly   646 GIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEVISFFTMANYKLVTEVVDFLKICKQEIGPHL 710
            .::.|:|:|.|.::|:||.::.|.|.|  .:|...|:|....:.:|..:|...:|.....:.|.|
Mouse   513 NVKLVVNFDMPSSMDEYVHQVGRVGRL--GQNGTAITFINNNSKRLFWDVAKRVKPTGSILPPQL 575

  Fly   711 LQ---LAEEKMFGPRQRRRHRPQRYNRM 735
            |.   |.|:|    |:.::...|..|.:
Mouse   576 LNSPYLHEQK----RKEQQKDRQTQNSL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	57/208 (27%)
		DEXDc	345..544	CDD:214692	54/204 (26%)
		Helicase_C	560..670	CDD:278689	25/111 (23%)
Ddx59	NP_080776.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101		27/135 (20%)
		PLN00206	70..593	CDD:215103	140/600 (23%)
		Q motif	203..231		13/27 (48%)
		DEAD box	353..356		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..603		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900