DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and Ddx55

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_080685.2	Gene:	Ddx55 / 67848	MGIID:	1915098	Length:	600	Species:	Mus musculus

Alignment Length:	476	Identity:	103/476 - (21%)
Similarity:	187/476 - (39%)	Gaps:	130/476 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 NITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGT 378
            ::|..:|....:|          .:..:|..|.:.|:...||:|:.|..:..:.|::...:..|:
Mouse     3 HVTEGAWESLQVP----------LHPRVLGALRELGFPHMTPVQSATIPLFMKNKDVAAEAVTGS 57

  Fly   379 GKTLGYLLPGI-MKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCL-LGN 441
            ||||.:::|.: :.:..:..|.:::.|.||  :...||.|:.:...:.::|......:..| :|.
Mouse    58 GKTLAFVIPILEILLRREEKLKKNQVGAIV--ITPTRELAIQIDEVLSHFTKHFPQFSQILWIGG 120

  Fly   442 -------SQWQGHAECDLLVASAGRLLQMIDNKKHVVELERCT----YLVLDNIDRMIDVGLEGN 495
                   .:::.|.. :::||:.|||..|...|...::|..|.    .||||..||::|:|.|.:
Mouse   121 RNPGEDVERFKQHGG-NIIVATPGRLEDMFRRKAEGLDLASCVKSLDVLVLDEADRLLDMGFEAS 184

  Fly   496 ICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL------GQYTAIRVGEINNIGVRLQNIRQRVE 554
            |..:|                         :||      |.::|.:..|:.|:
Mouse   185 INTIL-------------------------EFLPKQRRTGLFSATQTQEVENL------------ 212

  Fly   555 VVNGLSKVERL-MKEL-TAIYDTSDIPGKV---VIYVKRQKVVEELVDLIRN------------- 601
            |..||....|: :||. .|...|...|.::   .:..|..:...:||..:|:
Mouse   213 VRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYMICKADEKFNQLVHFLRSRQQEKHLVFFSTC 277

  Fly   602 -CVPCEG--------------IHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVI 651
             ||...|              |||....:.|: |..:|......|:|.|.:.:..:|:|.:.:|:
Mouse   278 ACVEYYGKALEALLKKVKILCIHGKMKYKRNK-IFMEFRKLQSGILVCTDVMARGIDIPEVNWVL 341

  Fly   652 NYDFPDNIDKYVQRMSRTGCLSYNRNCEV---------ISFFTMANYK-------LVTEVVDFLK 700
            .||.|.|...:|.|..||..:.:..:..|         |:|..: |.|       |....:|.|
Mouse   342 QYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEEAYINFLAI-NQKCPLQEMSLQRNTIDLL- 404

  Fly   701 ICKQEIGPHL--LQLAEEKMF 719
                   |.|  :.||:..:|
Mouse   405 -------PKLRAMALADRAVF 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	49/221 (22%)
		DEXDc	345..544	CDD:214692	50/217 (23%)
		Helicase_C	560..670	CDD:278689	32/142 (23%)
Ddx55	NP_080685.2	DEADc	9..224	CDD:238167	57/264 (22%)
		Q motif	9..37		7/37 (19%)
		DEXDc	24..228	CDD:214692	55/243 (23%)
		DEAD box	171..174		1/2 (50%)
		Helicase_C	252..363	CDD:278689	26/111 (23%)
		DUF4217	403..462	CDD:290667	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900