DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14443 and Ddx21

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_062426.2	Gene:	Ddx21 / 56200	MGIID:	1860494	Length:	851	Species:	Mus musculus

Alignment Length:	696	Identity:	150/696 - (21%)
Similarity:	277/696 - (39%)	Gaps:	123/696 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DNETDAEKVQKKPFLKGTKSSIWGSSASDISGQSRSLKSSSSVLSSKFVTKRLFTIQHGIEGQKP 79
            |...::.:...||..|.|:.....|...:      :.:.....:|||              .:|.
Mouse    14 DGAEESMETLPKPSEKKTRKEKTKSKTEE------ATEGMEEAVSSK--------------AKKT 58

  Fly    80 NFKIRSESFSGPHSAGGFSKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSSGSESSSSDSNSG 144
            |.|..||....|..:....|...|.:..:.|......:.|..|...::|..........|:..:.
Mouse    59 NKKGPSEDDVDPPKSRKAKKQEEEPQDDTASTSKTSKKKKEPLEKQADSETKEIITEEPSEEEAD 123

  Fly   145 SSSDSDSTTGSSSHGSDTGER-PRMRSAVFR-IHETWQSPNSFKAVKTSRENKESRSRSSSLPQK 207
            .........|..::| |.||: |::::.:.: ..|....|...|..|....|.::..:|..|...
Mouse   124 MPKPKKMKKGKEANG-DAGEKSPKLKNGLSQPSEEEADIPKPKKMKKGKEANGDAGEKSPKLKNG 187

  Fly   208 RFCPSKTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTRSRSP 272
            ...||:.:.|:    |:||........|...|.::|..|.                 ..::...|
Mouse   188 LSQPSEEEVDI----PKPKKMKKGKEASGDAGEKSPRLKD-----------------GLSQPSEP 231

  Fly   273 HRNTLCYQDQSKNPSRPSNYNTWKQ-PMDEVYNNAANYRKRHNITLTSWNMRNLPEPVLSFERSG 336
            ..|:      |..|...|:..|.|: |:::.....:|:                  |:
Mouse   232 KSNS------SDAPGEESSSETEKEIPVEQKEGAFSNF------------------PI------- 265

  Fly   337 FNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQH 401
             :...::.|:.:|.:...||||:|:.....||:::..:..|||||..:.:|.|.|:  |.||.:.
Mouse   266 -SEETVKLLKARGVNFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKL--QGGLQER 327

  Fly   402 KKG--PIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGR 459
            |:|  |.||:|...||.|..|.::....|..|.:.  |..|.:.:.|..|     .|:||.:.||
Mouse   328 KRGRAPQVLVLAPTRELANQVSKDFSDITKKLSVA--CFYGGTPYGGQIERMRSGIDILVGTPGR 390

  Fly   460 LLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLC-------RLRPHAQLIVSST--S 515
            :...:.|.|  ::|.:..::|||.:|:|:|:|....:..:||       ...|.. |:.|:|  .
Mouse   391 IKDHLQNGK--LDLTKLKHVVLDEVDQMLDMGFADQVEEILCVAYKKDSEDNPQT-LLFSATCPH 452

  Fly   516 WSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVE-VVNGLSKVER--LMKELTAIYDTSD 577
            |..|:.:       :|......:::.||.:.|.....|| :.......||  ::.::..:|  |.
Mouse   453 WVFNVAK-------KYMKSTYEQVDLIGKKTQKAAITVEHLAIKCHWTERAAVIGDVIRVY--SG 508

  Fly   578 IPGKVVIYVKRQKVVEELVDLIRNCV--PCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSN 640
            ..|:.:|:.:.:|..:||..  ..|:  ..:.:||....::.:..:..|..|.:.::|||.:.:.
Mouse   509 HQGRTIIFCETKKDAQELSQ--NTCIKQDAQSLHGDIPQKQREITLKGFRNGNFGVLVATNVAAR 571

  Fly   641 CLDVPGIRYVINYDFPDNIDKYVQRMSRTG-------CLSYNRNCE 679
            .||:|.:..|:....|.:::.|:.|..|||       |:.:.:|.|
Mouse   572 GLDIPEVDLVVQSCPPKDVESYIHRSGRTGRAGRTGVCICFYQNKE 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	60/218 (28%)
		DEXDc	345..544	CDD:214692	61/214 (29%)
		Helicase_C	560..670	CDD:278689	25/113 (22%)
Ddx21	NP_062426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..260		53/293 (18%)
		3 X 37 AA tandem repeats	117..227		24/131 (18%)
		PRK01297	191..633	CDD:234938	115/498 (23%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	258..286		6/53 (11%)
		DEADc	260..467	CDD:238167	62/246 (25%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	411..414		1/2 (50%)
		HELICc	501..610	CDD:238034	25/112 (22%)
		GUCT_RHII_Gualpha_beta	689..781	CDD:240593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..851
		AdoMet_MTases	794..>840	CDD:302624
		3 X 5 AA repeats	807..833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910