DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14443 and bel

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	182/750 - (24%)
Similarity:	305/750 - (40%)	Gaps:	132/750 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GSSASDISGQSRSLKSSSSVLSSKFVTKRLFTIQHGIEGQKPNFKIRSESFSGPHSAGGFSKSTR 102
            |.|| |.||...|..|::||....:|...|    .|..|........|:. .|.....||...:.
  Fly    23 GGSA-DYSGPITSKTSTNSVTGGVYVPPHL----RGGGGNNNAADAESQG-QGQGQGQGFDSRSG 81

  Fly   103 ESRSKSRSM-----GNGKFR------GKSHLRSSSESAHSSGSESSS------SDSNSGSSSDS- 149
            ..|.::|..     |.|::|      |:...|.|.:..:.||.....      .|:.:|...||
  Fly    82 NPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGDYGYGSGGGGRRGGGGRFEDNYNGGEFDSR 146

  Fly   150 -----DSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRSSSLPQKRF 209
                 :.:.|....|...|..|..|..              .....|..|:::.....:..|:
  Fly   147 RGGDWNRSGGGGGGGRGFGRGPSYRGG--------------GGGSGSNLNEQTAEDGQAQQQQ-- 195

  Fly   210 CPSKTQNDLTYGSPE----------------PKSPSNRGRNSWRVGMRTPWKKSQSRSMSCSSIQ 258
               :.:|| .:..||                .:|.:|||..... |..:.||:....::
  Fly   196 ---QPRND-RWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGG-GYNSRWKEGGGSNV------ 249

  Fly   259 KILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANYRKRHNITLTSWNMR 323
                                  |.:|..:|......   .:..|.|...|:.|..:|.:.:.. :
  Fly   250 ----------------------DYTKLGARDERLEV---ELFGVGNTGINFDKYEDIPVEATG-Q 288

  Fly   324 NLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPG 388
            |:|..:.||:.......|...:....||.|||:|.....|...|::::..:..|:|||..:|:|.
  Fly   289 NVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPI 353

  Fly   389 IMKMH---------NQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQW 444
            :.:|:         :.|...:.|:.|:.|:|...||.|..:..|...:.....:|...|.|.:..
  Fly   354 LNQMYELGHVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNT 418

  Fly   445 QGHAE-----CDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLR 504
            .....     |.|:||:.|||..||...|  |.||...:||||..|||:|:|.|..|.|::.:|.
  Fly   419 SEQMRELDRGCHLIVATPGRLEDMITRGK--VGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLN 481

  Fly   505 ----PHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVERL 565
                ...|.::.|.::...::.:|:.||..|..:.||   .:|...:||.|.:..|....|...|
  Fly   482 MPPTGQRQTLMFSATFPKQIQELASDFLSNYIFLAVG---RVGSTSENITQTILWVYEPDKRSYL 543

  Fly   566 MKELTAIYD----TSDIPGKVVIYVKRQKVVEELVDLIRNC-VPCEGIHGGRTAQENQGIIHDFG 625
            :..|::|.|    |.|  ...:|:|:.:|..:.|.:.:..| .|...|||.||.:|.:..:..|.
  Fly   544 LDLLSSIRDGPEYTKD--SLTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFR 606

  Fly   626 TGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEV-ISFFTMANY 689
            :|...|:|||.:.:..||:|.:::|||:|.|.::::||.|:.|||.:.   |..| .|||...|.
  Fly   607 SGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMG---NLGVATSFFNEKNR 668

  Fly   690 KLVTEVVDFLKICKQEIGPHLLQLAEEKMFGPRQR 724
            .:.:::::.|...||||...:..::.::..|..:|
  Fly   669 NICSDLLELLIETKQEIPSFMEDMSSDRGHGGAKR 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	61/220 (28%)
		DEXDc	345..544	CDD:214692	61/216 (28%)
		Helicase_C	560..670	CDD:278689	37/114 (32%)
bel	NP_001262379.1	DEADc	297..516	CDD:238167	61/220 (28%)
		DEXDc	315..529	CDD:214692	64/218 (29%)
		Helicase_C	538..654	CDD:278689	39/117 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940