DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and Ddx5

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001007614.1	Gene:	Ddx5 / 287765	RGDID:	619906	Length:	615	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	164/561 - (29%)
Similarity:	267/561 - (47%)	Gaps:	81/561 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 TSRENKESRSRSSSLPQKRFCPSKT--QNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSM 252
            :|..:...|.|.......||..|:|  .:...:|:|..|
  Rat     2 SSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEK-------------------------- 40

  Fly   253 SCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANYRKRHNITL 317
                    ||.:.:.....|......||:      .|.......|.:|       .||:...||:
  Rat    41 --------LVKKKWNLDELPKFEKNFYQE------HPDLARRTAQEVD-------TYRRSKEITV 84

  Fly   318 TSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTL 382
            ..   .|.|:|||:|..:.|.|.::..:..|.:..||.||||.|.:|..|.::|.::..|:||||
  Rat    85 RG---HNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTL 146

  Fly   383 GYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGH 447
            .||||.|:.: |.:..::...|||.|:|...||.|..||:....|.....|::.|:.|.:. :|.
  Rat   147 SYLLPAIVHI-NHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAP-KGP 209

  Fly   448 AECDL------LVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPH 506
            ...||      .:|:.|||:..::..|  ..|.|.||||||..|||:|:|.|..|.:::.::||.
  Rat   210 QIRDLERGVEICIATPGRLIDFLECGK--TNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPD 272

  Fly   507 AQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEIN---NIGVRLQNIRQRVEVVNGLSKVERLMKE 568
            .|.::.|.:|...::::|..||..|..|.:|.:.   |     .||.|.|:|.:.:.|.|:|::.
  Rat   273 RQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSAN-----HNILQIVDVCHDVEKDEKLIRL 332

  Fly   569 LTAIYDTSDIPGKVVIYVKRQKVVEELV-DLIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNII 632
            :..|  .|:...|.:::|:.::..:||. .:.|:..|..||||.::.||...::::|..|...|:
  Rat   333 MEEI--MSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPIL 395

  Fly   633 VATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEVISFFTMANYKLVTEVVD 697
            :||.:.|..|||..:::|||||:|::.:.|:.|:.||.  ...:.....:|||..|.|.|::::.
  Rat   396 IATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTA--RSTKTGTAYTFFTPNNIKQVSDLIS 458

  Fly   698 FLKICKQEIGPHLLQLAEEKMFGPRQRRR-----HRPQRYN 733
            .|:...|.|.|.||||.|::..| |.|.|     .|..||:
  Rat   459 VLREANQAINPKLLQLVEDRGSG-RSRGRGGMKDDRRDRYS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	71/208 (34%)
		DEXDc	345..544	CDD:214692	71/207 (34%)
		Helicase_C	560..670	CDD:278689	35/110 (32%)
Ddx5	NP_001007614.1	PTZ00110	6..507	CDD:240273	163/557 (29%)
Ddx5	NP_001007614.1	P68HR	498..532	CDD:400414	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820