DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and Gpr149

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_796320.2	Gene:	Gpr149 / 229357	MGIID:	2443628	Length:	732	Species:	Mus musculus

Alignment Length:	384	Identity:	74/384 - (19%)
Similarity:	121/384 - (31%)	Gaps:	132/384 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CEKAKKLVIGNWKDNET-----DAEKVQKKPFLKGTKSSIWGSSASDISGQSRSLKSSSSVLSSK 61
            ||..|:    .|.||.:     ..|.....|....|.:.:...:.:||....:::|......|.|
Mouse   436 CEATKE----PWGDNRSVFNTITVEISTTPPLDSATLTGVHKCTNTDIPESKQAMKEEKGAFSVK 496

  Fly    62 FVTKRLFTIQHGIEGQKPNFKIRSESFSGPHSAGGF---------------SKSTRESRSKSRSM 111
            ..:    .|.:|          .:.||.||......               |||.|..|.:|
Mouse   497 TES----DINYG----------ETTSFEGPERRLSHEENQKPDLSDWEWCRSKSERTPRQRS--- 544

  Fly   112 GNG------KFRGKSHLRS-SSESAHSSGSESSSSDSNSGSSSDSDSTTGSSSHGSDTGERPRMR 169
            |.|      .|:|...|:: :.::...|..|.|:.......:|.......|.|.|.:....
Mouse   545 GGGLAIPICAFQGTVSLQAPTGKTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSE---- 605

  Fly   170 SAVFRIHETWQSPNSF--KAVKTSRE------NKESRSRSSSLPQKRFCPSKTQNDLTYGSPEPK 226
                      :||::|  .:||...|      |.|:....|.:           ::::..|.:.:
Mouse   606 ----------ESPSTFADTSVKIHLEVLEICDNDEALDTVSII-----------SNISQSSTKVR 649

  Fly   227 SPSNRGRNSWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSN 291
            |||.|            :.:.::|.:||...:....| .|..:..|        |...|.|.|
Mouse   650 SPSLR------------YSRKENRFVSCDLGETASYS-LFLPTSDP--------DGDINISIP-- 691

  Fly   292 YNTWKQPMDEVYNNAANYRKRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGY 350
                    |.|..:..|.|::|.                  ||.|:...|  ||.::.|
Mouse   692 --------DTVEAHRQNSRRQHE------------------ERDGYQEEI--QLLNKAY 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	7/19 (37%)
		DEXDc	345..544	CDD:214692	2/6 (33%)
		Helicase_C	560..670	CDD:278689
Gpr149	NP_796320.2	7tm_1	56..>211	CDD:278431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..302
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..526		6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900