Protein Alignment CG14443 and Ddx46

DIOPT Version :10

• Sequence 1: NP_572330.2
• Gene: CG14443 / 31595
• FlyBaseID: FBgn0029880
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_001268984.1
• Gene: Ddx46 / 212880
• MGIID: 1920895
• Length: 1032
• Species: Mus musculus
• Alignment Length: 700
• Identity: 176/700 - (25%)
• Similarity: 304/700 - (43%)
• Gaps: 110/700 - (15%)

  Fly    98 SKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSSGSESSSSDSNSGSSSDS------DSTTGSS 156
            |:..|.|||:.|.....:.||: ..||||..:.:..:|:.|.........||      |......
Mouse    79 SRERRRSRSRDRRRSRSRSRGR-RSRSSSPGSKTKKTENRSRSKEKAEGGDSSKEKKKDKDDKED 142

  Fly   157 SHGSDTGE------RPRMRSAVFRIHETWQSPNSFKAVKTSRENKE-----SRSRSSSL---PQK 207
            ....|.|.      ...||....|: |.|:.....||::...|.|:     .:.:..||   ...
Mouse   143 EKEKDAGNFDQNKLEEEMRKRKERV-EKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDD 206

  Fly   208 RFCPSKTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSM---------SCSSIQKIL-- 261
            ...|::.:.:.|....|...|    .:::...::...||...||:         |..::.|::
Mouse   207 EDDPAEAEKEGTEMEDEELDP----LDAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTV 267

  Fly   262 -----------------------------------VSRSFTRSRSPHRNTLCYQDQSKNPSRPSN 291
                                               :..:.|..::..|..|...|..|....|..
Mouse   268 VTTKKAVVDADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFR 332

  Fly   292 YNTW-------KQPMDEVYNNAANYR-KRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQ 348
            .|.:       |...:||  |.  :| :...||:..   :..|:|:.|:.:.|.:..||..|:..
Mouse   333 KNFYVEVPELAKMSQEEV--NV--FRLEMEGITVKG---KGCPKPIKSWVQCGISMKILNSLKKH 390

  Fly   349 GYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDC 413
            ||:.|||||.|.......|::::.|:..|:|||:.:|||....:.:||.| :..:|||.:|:...
Mouse   391 GYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSL-EEGEGPIAVIMTPT 454

  Fly   414 REAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE--------CDLLVASAGRLLQMI-DNKKH 469
            ||.|:.:.:|...::..|.||..|:.|.:   |.:|        .:::|.:.||::.|: .|...
Mouse   455 RELALQITKECKKFSKTLGLRVVCVYGGT---GISEQIAELKRGAEIIVCTPGRMIDMLAANSGR 516

  Fly   470 VVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAI 534
            |..|.|.||:|||..|||.|:|.|..:.|::..:||..|.::.|.::...::.:|.:.|.:...:
Mouse   517 VTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEV 581

  Fly   535 RVGEINNIGVRLQNIRQRVEVVNGLSKVERLMKELTAIYDTSDIPGKVVIYVKRQKVVEELV-DL 598
            :||   ...|...::.|:|.|:....|..:|: ||...|..|   |.|:|:|.:|:..:.|: ||
Mouse   582 QVG---GRSVVCSDVEQQVIVIEEEKKFLKLL-ELLGHYQES---GSVIIFVDKQEHADGLLKDL 639

  Fly   599 IRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYV 663
            :|...||..:|||....:...||:||..|...::|||.:.:..|||..:..|:||..|::.:.||
Mouse   640 MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYV 704

  Fly   664 QRMSRTGCLSYNRNCEVISFFTMANYKLVTEVVDFLKICKQEIGPHLLQL 713
            .|..||| .:.|:. ...:|.|....:...:::..|::....:.|.|.:|
Mouse   705 HRAGRTG-RAGNKG-YAYTFITEDQARYAGDIIKALELSGTAVPPDLEKL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	DEAD-like_helicase_N	<310..720	CDD:475120	124/414 (30%)
Ddx46	NP_001268984.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..227		33/149 (22%)
		DEADc_DDX46	361..582	CDD:350711	69/227 (30%)
		Q motif	372..400		11/27 (41%)
		SrmB	378..793	CDD:440279	118/387 (30%)
		DEAD box	529..532		1/2 (50%)
		KH-I_DDX46	929..1031	CDD:411901