DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14443 and DDX17

DIOPT Version :9

Sequence 1:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001091974.1	Gene:	DDX17 / 10521	HGNCID:	2740	Length:	731	Species:	Homo sapiens

Alignment Length:	596	Identity:	169/596 - (28%)
Similarity:	285/596 - (47%)	Gaps:	80/596 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SSDSDSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRSSSLPQKRFC 210
            |...::.|.:|:.|....||   .||......|.::|.  .:|.|..|.:...|.:...|.....
Human    16 SPTREAATVASATGDSASER---ESAAPAAAPTAEAPP--PSVVTRPEPQALPSPAIRAPLPDLY 75

  Fly   211 PSKTQNDLTYGSPEPKSPSNRGRNSWRVGMR-----------TPWKKSQSRSMSCSSIQKILVSR 264
            |..|.....:|.      .:|.|:....|.|           .|.::.:.:....|.:.|.
Human    76 PFGTMRGGGFGD------RDRDRDRGGFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKF---- 130

  Fly   265 SFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANYRKRHNITLTSWNMRNLPEPV 329
                    .:|   :..:....:|.:.|.     :||:       |::..||:...::  .|:||
Human   131 --------EKN---FYVEHPEVARLTPYE-----VDEL-------RRKKEITVRGGDV--CPKPV 170

  Fly   330 LSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHN 394
            .:|..:.|...::..|.||.:..|||||.|.:.:|..|:::|.|:..|:||||.||||.|:.: |
Human   171 FAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHI-N 234

  Fly   395 QRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAECDL------L 453
            .:..::...|||.|:|...||.|..||:....|.....|::.|:.|.:. :|....||      .
Human   235 HQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAP-KGPQIRDLERGVEIC 298

  Fly   454 VASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSS 518
            :|:.|||:..:::.|  ..|.||||||||..|||:|:|.|..|.:::.::||..|.::.|.:|..
Human   299 IATPGRLIDFLESGK--TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPK 361

  Fly   519 NLKRMANKFLGQYTAIRVGEIN---NIGVRLQNIRQRVEVVNGLS---KVERLMKELTAIYDTSD 577
            .::::|..||..||.|.||.:.   |     .||.|.|:|.....   |:.:||:|:.|     :
Human   362 EVRQLAEDFLRDYTQINVGNLELSAN-----HNILQIVDVCMESEKDHKLIQLMEEIMA-----E 416

  Fly   578 IPGKVVIYVKRQKVVEELV-DLIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNC 641
            ...|.:|:|:.::..::|. .:.|:..|...|||.::..|...::::|.:|...|::||.:.|..
Human   417 KENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRG 481

  Fly   642 LDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEVISFFTMANYKLVTEVVDFLKICKQEI 706
            |||..:::|||||:|::.:.||.|:.|| ..|.|:. ...:|||..|.|...|::..|:...|.|
Human   482 LDVEDVKFVINYDYPNSSEDYVHRIGRT-ARSTNKG-TAYTFFTPGNLKQARELIKVLEEANQAI 544

  Fly   707 GPHLLQLAEEK 717
            .|.|:||.:.:
Human   545 NPKLMQLVDHR 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	74/208 (36%)
		DEXDc	345..544	CDD:214692	76/207 (37%)
		Helicase_C	560..670	CDD:278689	34/113 (30%)
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..115		22/105 (21%)
		Q motif	171..199		9/27 (33%)
		DEADc	173..378	CDD:238167	74/208 (36%)
		DEXDc	191..393	CDD:214692	75/210 (36%)
		DEAD box	325..328		1/2 (50%)
		HELICc	389..521	CDD:238034	42/138 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..731
		Interaction with YAP1. /evidence=ECO:0000269\|PubMed:24581491	720..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920