Protein Alignment APC7 and Anapc7

DIOPT Version :10

• Sequence 1: NP_572329.3
• Gene: APC7 / 31594
• FlyBaseID: FBgn0029879
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_062779.3
• Gene: Anapc7 / 56317
• MGIID: 1929711
• Length: 565
• Species: Mus musculus
• Alignment Length: 550
• Identity: 148/550 - (26%)
• Similarity: 249/550 - (45%)
• Gaps: 20/550 - (3%)

  Fly    35 ADLLRTVLKNDRYVATLDVEYQVLLYLLNANYKERNYRAALRHFDEII-HKRRLMMRHKNAVLVA 98
            :.||.|:..|:..:.:...:||:|:|..::.:.::.||.|:..:...: .|:.|....|......
Mouse    23 SSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYAMALQQKKALSKTSKVRPSTG 87

  Fly    99 IESSYPEF----GDAEQRRRAAECYRQIGNTDMAIETLLQVPPTLRSPRINLMLARLQHHGSRHG 159
            ..:|.|:.    .:.|.:.:.||||..:.....||..|..:|...|:|:||:|||.|.   .:.|
Mouse    88 NSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAVLDGIPSRQRTPKINMMLANLY---KKAG 149

  Fly   160 TTKKSEAVLAYKEVIRECPMALQVIEALLELGVNGNEINSLVMHAATVPDHFDWLSKWIKALAQM 224
            ..:.|  |.:||||:|:||:||..|..||.|.|.|.|:.|:.|:......:.||||.||||.|.:
Mouse   150 QERPS--VTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFV 212

  Fly   225 FNFKHSDASQTFLMLHDNTTLRCNEHLMMALGKCLYYNGDYFQAEDIFSSTLCANPDNVEAIGLM 289
            ....:|.|..|...|...:.||.|..|:.:|....:..||...:...|......:|..:..:.:.
Mouse   213 HTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDSKNSVLKFEQAQMLDPYLIRGMDVY 277

  Fly   290 AVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDEGKFERGLNFVEKCLDSEPRN 354
            ..|..:||..|    |::.|..::.:.....|..|.......:...::.|.|....|.:.....:
Mouse   278 GYLLAREGRLE----DVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNS 338

  Fly   355 HEALILRGRLLIALERHTQAVCAFRTAQMVAPYRFEIYRGLFHSYLAQKRFKEANALCNWTIRLF 419
            .:||:|:|..|..:.|..:|:..||.|..:||.|.:.|.||...|||....:||..:.|...:..
Mouse   339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTL 403

  Fly   420 QNSPRSFTMFGRTLFLFPDPRMRRTARKFAEKSLKINHIYTPAVNLIADICQVEGPTKAIIKLLE 484
            ..:.::.|:.. |:.| .||..:..|:...:|:|.....|..||...|::...|...:..|.||.
Mouse   404 GANAQTLTLLA-TVCL-EDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLR 466

  Fly   485 KHVIIFPKVNLLNHLGDIMRKQKEPVKAMEYYYKALRQDPKSKRTLRGLRLLAKSDDESPVLDES 549
            ..:.......|...|||.:....|..:||:.|..||..||..:::|.|::.:.|.:..:....|.
Mouse   467 NALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEE 531

  Fly   550 DDIGMDNQQSINDLTTLCEATNAQGAEGAE 579
            |...|:......||    |.::::.|:.|:
Mouse   532 DVDDMEGSGEEGDL----EGSDSEAAQWAD 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APC7	NP_572329.3	CpoB	34..135	CDD:441335	24/104 (23%)
		LapB	108..411	CDD:442196	92/302 (30%)
		TPR repeat	251..277	CDD:276809	5/25 (20%)
		LapB	254..523	CDD:442196	64/268 (24%)
		TPR repeat	321..349	CDD:276809	5/27 (19%)
		TPR repeat	354..384	CDD:276809	10/29 (34%)
		TPR repeat	459..489	CDD:276809	8/29 (28%)
		TPR repeat	493..521	CDD:276809	9/27 (33%)
Anapc7	NP_062779.3	TPR 1	101..134		9/32 (28%)
		TPR 2	169..202		11/32 (34%)
		TPR 3	203..236		12/32 (38%)
		Spy	233..>392	CDD:443119	39/162 (24%)
		TPR 4	237..270		6/32 (19%)
		LapB	319..529	CDD:442196	56/211 (27%)
		TPR repeat	338..368	CDD:276809	10/29 (34%)
		TPR 5	339..372		12/32 (38%)
		TPR 6	373..406		9/32 (28%)
		TPR 7	407..439		8/33 (24%)
		TPR 8	442..474		7/31 (23%)
		TPR repeat	442..470	CDD:276809	7/27 (26%)
		TPR 9	475..508		12/32 (38%)
		TPR repeat	475..503	CDD:276809	9/27 (33%)
		TPR 10	509..531		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	513..565		10/48 (21%)