DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC7 and Cdc16

DIOPT Version :9

Sequence 1:	NP_572329.3	Gene:	APC7 / 31594	FlyBaseID:	FBgn0029879	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	132/699 - (18%)
Similarity:	221/699 - (31%)	Gaps:	256/699 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EKMEIALFAN-AKKLYDHKLYECVIPAADLLRTVLKNDRYVATL------DVEYQV-LLYLLNAN 65
            |.:::||:.. .|:..|.:.|.          |.|.....||.|      |:.||. .:|||...
  Fly    15 EHIDLALYRQLVKQFIDMRRYS----------TALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEY 69

  Fly    66 YK----------ERN------------YRAALRHFDE---IIHKRRLMMRHKNAVLVAIESS--- 102
            ::          |:|            |  |.:.|.|   :|....:.:...:.:...:::|
  Fly    70 HRAAHTIQHHKLEKNSLPCFNLLLESLY--AAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGC 132

  Fly   103 YPE----FGDAEQRRR---------AAECYRQIGNTDMAIETLLQVPPTLRSP--RINLMLARLQ 152
            |.|    ||..|..|.         ..:.|..:.|..||::..:|   .|...  ....:.|.:|
  Fly   133 YLESNSVFGGEENHRNELLSSIYLMKGKVYEALDNRGMAMDFYVQ---ALHKSIYCFEALEALVQ 194

  Fly   153 HHGSRHGTTKKSEAVLAYK--EVIRECPMALQVIEA----LLEL-------------GVNGNEIN 198
            |           |.::|::  |::...|:|.|..||    :|:|             ..|..|::
  Fly   195 H-----------EMLMAWEEFELMHHLPLAQQSSEADAKFILKLYESRLKKYYELISARNAEEMS 248

  Fly   199 SLV---------------------------MHAATVP-DHFDWLSKWIKAL----AQMFNFKHS- 230
            .:|                           :.|..|| ....::|...|.|    |..|:.:.|
  Fly   249 PIVNPDILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSL 313

  Fly   231 -------DASQTFLM---------LHDNTTL----RC------NEHLMMALGKCLYYNGDYFQAE 269
                   |||...:.         .||..||    .|      :..||.|..:..:|:.||.|..
  Fly   314 SKASSLIDASHRSMFDSSSRRRSRDHDTDTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCL 378

  Fly   270 DIFSSTLCANPDNVEAIGLMAVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDE 334
            .|.:..|..:|.:..|:.:. :.|..|.|   |...:.|:..|:.......|..|:| ....||.
  Fly   379 KILNELLKVDPFHNTALTIQ-IACLVENG---DFNRLFYVAHKLVDRYPDKAISWYA-VGCYYDM 438

  Fly   335 -GKFERGLNFVEKCLDSEPRNHEALILRGRLLIALERHTQAVCA-FRTAQM-------------- 383
             ||.:....::.|....:.....|.:..|........|.||:.| |:..|:
  Fly   439 IGKSDPARRYLSKATALDRLYGPAWLAYGHSFANENEHEQAMAAYFKATQLMRGCHLPLLYIGVE 503

  Fly   384 -------------------VAP-------------YRFEIYRG---------------------- 394
                               :||             |.:|.:.|
  Fly   504 CGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEE 568

  Fly   395 -----------LFHSYLAQKRFKEANALCNWTIRLFQNSPRSFTMFG--RTLFLFPDPRMRRTAR 446
                       |.||.....:::||.....:.:.|...||.::|..|  ..|....||     |.
  Fly   569 ISSRWEPLFINLGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIGFIHALLGNLDP-----AI 628

  Fly   447 KFAEKSLKINH--IYTPAV------NLIADICQVEGPTKAIIKLLEKHV 487
            :...|||.:|.  |.|..:      :|:.|...::....|.::.:.|::
  Fly   629 EAFHKSLALNRDCIVTSTILKSCIEDLMDDSATIDEICSAALRDVAKNI 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC7	NP_572329.3	TPR repeat	251..277	CDD:276809	8/25 (32%)
		TPR_11	321..386	CDD:290150	16/99 (16%)
		TPR repeat	321..349	CDD:276809	8/28 (29%)
		TPR repeat	354..384	CDD:276809	8/63 (13%)
		TPR_11	356..418	CDD:290150	18/141 (13%)
		TPR repeat	459..489	CDD:276809	5/35 (14%)
		TPR repeat	493..521	CDD:276809
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	20/92 (22%)
		TPR_11	425..489	CDD:290150	15/64 (23%)
		TPR repeat	426..454	CDD:276809	8/28 (29%)
		TPR repeat	462..488	CDD:276809	7/25 (28%)
		TPR repeat	493..523	CDD:276809	0/29 (0%)
		TPR repeat	528..552	CDD:276809	3/23 (13%)
		TPR_11	576..638	CDD:290150	17/66 (26%)
		TPR repeat	576..602	CDD:276809	5/25 (20%)
		TPR repeat	607..637	CDD:276809	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12558
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940