DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment APC7 and Cdc27

DIOPT Version :9

Sequence 1:	NP_572329.3	Gene:	APC7 / 31594	FlyBaseID:	FBgn0029879	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	63/290 - (21%)
Similarity:	109/290 - (37%)	Gaps:	72/290 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 AIGLMAVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDEGKFERGLNFVEKCLD 349
            |.||||:|.|                              .|.|..|....:.:..:..:|..:
  Fly   536 ADGLMALLRG------------------------------LAEAYQLLSNFQCKAAIKQLETTI- 569

  Fly   350 SEPRNH------EALILRGRLLIALERHTQAVCAFRTAQMVAPYR---FEIY-RGLFHSYLAQKR 404
              |::|      ::||  |.....:..:..||..|.|.....|.|   .||| ..|:|    .:|
  Fly   570 --PKHHLNSSWVQSLI--GLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWH----LQR 626

  Fly   405 FKEANALCNWTIRLFQNSPRSFTMFGRTLFLFPDPRMRRTARKFAEKSLKINHIYTPAVNLIA-D 468
            ..|.:||....|...:.||.::.:.|....|   .:...||.||.:::::::..:..:..|:. :
  Fly   627 EVELSALAQDLINQDKTSPVTWCVSGNCFSL---QKEHETAIKFFKRAVQVDPDFVYSYTLLGHE 688

  Fly   469 ICQVEGPTKAIIKLLEKHVIIFPK-VNLLNHLGDIMRKQKEPVKAMEYYYKALRQDP-------- 524
            :...|...|| :......|:..|: .|....:|.|..||::...|..:|.|||:.:|
  Fly   689 LVLTEEFDKA-MDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVH 752

  Fly   525 ---------KSKRTLRGLRLLAKSDDESPV 545
                     |...:|:.|...|..|.::|:
  Fly   753 IGAMQFYMKKKDLSLQTLNTAATLDPKNPL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC7	NP_572329.3	TPR repeat	251..277	CDD:276809
		TPR_11	321..386	CDD:290150	13/70 (19%)
		TPR repeat	321..349	CDD:276809	4/27 (15%)
		TPR repeat	354..384	CDD:276809	8/35 (23%)
		TPR_11	356..418	CDD:290150	19/65 (29%)
		TPR repeat	459..489	CDD:276809	5/30 (17%)
		TPR repeat	493..521	CDD:276809	9/27 (33%)
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650
		TPR_11	67..145	CDD:290150
		TPR repeat	68..104	CDD:276809
		TPR repeat	109..143	CDD:276809
		TPR_12	539..601	CDD:290160	16/96 (17%)
		TPR repeat	582..605	CDD:276809	7/24 (29%)
		TPR	590..850	CDD:223533	47/201 (23%)
		TPR_1	645..678	CDD:278916	7/35 (20%)
		TPR repeat	678..708	CDD:276809	5/30 (17%)
		TPR_1	713..746	CDD:278916	11/32 (34%)
		TPR repeat	713..741	CDD:276809	9/27 (33%)
		TPR repeat	747..773	CDD:276809	3/25 (12%)
		TPR repeat	781..809	CDD:276809	1/2 (50%)
		TPR repeat	815..838	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12558
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940