DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pat1 and Klc4

DIOPT Version :9

Sequence 1:NP_001259286.1 Gene:Pat1 / 31593 FlyBaseID:FBgn0029878 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_001344059.1 Gene:Klc4 / 74764 MGIID:1922014 Length:619 Species:Mus musculus


Alignment Length:555 Identity:130/555 - (23%)
Similarity:189/555 - (34%) Gaps:146/555 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 AGH--EEEELESSMDTVEDRSTEFSSLYTYDSESTNADSISDFNDEFSADIGSIVGLPHRRATQE 186
            |||  .:||:..|...|.      ..|....||............|.....|...||.|.:|.|.
Mouse    13 AGHRLSQEEILGSTKVVS------QGLEALHSEHQAVLQSLSHTIECLQQGGHEEGLVHEKARQL 71

  Fly   187 ELDAIN-DSGLEE----------LSAVELQVIDLGLRLGSFLSEAGWMQESITVLACLNVRLK-- 238
            .....| :.||.|          ||.||.:...|..::.....|..|:::.   ||....||:  
Mouse    72 RRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDE---LAGTQQRLQRS 133

  Fly   239 -----DLPTHKHWLQFRLDCLQRLLYAESAH-CNFKEAEKTYAELMGLNKWLNKSVPNQLVAITY 297
                 .|...|..|:|.....|   |.|..| ...||.|.|...|..|       .||:     .
Mouse   134 EQAVAQLEEEKKHLEFLRQLRQ---YDEDGHGMEEKEGEATKDSLDDL-------FPNE-----E 183

  Fly   298 SQISAMYFARNEYKNSHLWSGLAMRFLKGYANP---RTIIDVLRQAAKACVVKRDFARANLLICQ 359
            .:.|....:|.:        |.|.....||..|   ||:.:::.|.|    .:..:..|..|..|
Mouse   184 EEDSGNDLSRGQ--------GAAAAQQGGYEIPARLRTLHNLVIQYA----AQGRYEVAVPLCKQ 236

  Fly   360 AVRRAREYFGPTHQKYGDALLDYGFFLLNVDS-VFQSVNIYKEALAVRRGIFGNMNFHVAIAHED 423
            |:.......|..|.....        :||:.: |::..|.||||                 ||. 
Mouse   237 ALEDLERTSGRGHPDVAT--------MLNILALVYRDQNKYKEA-----------------AHL- 275

  Fly   424 LSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLVPSNHLMLASAKRVKALLLEEIALDKMADGIDE 488
            |:.|..:.|.:.|     :||...|..:       |:|.:...||.|                  
Mouse   276 LNDALSIRESTLG-----RDHPAVAATL-------NNLAVLYGKRGK------------------ 310

  Fly   489 EDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKKAIKIKSELLG 553
               ..::|.|...||.:..:|.|..:...||...||..|.|...::|..||.:::|:.|....||
Mouse   311 ---YKEAEPLCQRALEIREKVLGTDHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYESQLG 372

  Fly   554 HFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSIDISLRLFGNSYSGLEYDYLGLCHVYE--TL 616
            ..:..|..:..:|||.| .:..||.:||.||.                   :.|...||.|  ::
Mouse   373 PDNPNVARTKNNLASCY-LKQGKYSEAEALYK-------------------EILTCAHVQEFGSV 417

  Fly   617 HNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIE 651
            .:..|.: :.|..|..:|.|.:   ...||.|..|
Mouse   418 DDDHKPI-WMHAEEREEMSRSR---PRDSSAPYAE 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pat1NP_001259286.1 DnaQ_like_exo <53..110 CDD:299142
TPR_12 478..547 CDD:290160 16/68 (24%)
TPR_12 516..590 CDD:290160 24/73 (33%)
TPR_10 517..553 CDD:290111 11/35 (31%)
TPR repeat 518..546 CDD:276809 10/27 (37%)
TPR repeat 559..590 CDD:276809 11/30 (37%)
TPR repeat 603..628 CDD:276809 5/26 (19%)
Klc4NP_001344059.1 TPR repeat 212..239 CDD:276809 8/30 (27%)
TPR_12 251..327 CDD:315987 26/134 (19%)
TPR 3 253..286 13/58 (22%)
TPR repeat 253..281 CDD:276809 12/53 (23%)
TPR_12 294..369 CDD:315987 23/102 (23%)
TPR 4 295..328 10/60 (17%)
TPR repeat 295..323 CDD:276809 9/55 (16%)
TPR_12 335..406 CDD:315987 24/90 (27%)
TPR repeat 336..366 CDD:276809 10/29 (34%)
TPR 5 337..370 11/32 (34%)
TPR_12 378..496 CDD:315987 24/95 (25%)
TPR 6 379..412 12/52 (23%)
TPR repeat 379..406 CDD:276809 10/46 (22%)
TPR 7 464..497
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 571..619
SMC_prok_B 33..>148 CDD:274008 27/117 (23%)
TPR 1 55..88 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..199 14/62 (23%)
TPR_12 210..285 CDD:315987 22/104 (21%)
TPR 2 211..244 8/36 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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