DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pat1 and ttc19

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001333173.1	Gene:	ttc19 / 564788	ZFINID:	ZDB-GENE-070912-490	Length:	403	Species:	Danio rerio

Alignment Length:	411	Identity:	74/411 - (18%)
Similarity:	150/411 - (36%)	Gaps:	103/411 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LACLNVRLK----DLPTHKHWLQFRLDCLQRL-----LYAESAHCNFKEAEKTYAELMGLNKWLN 285
            ||....|||    :.|.:.....|.|..::.|     :.|.|:.|              :.:|..
Zfish    10 LAAQVFRLKLCGNECPRNAPGCSFSLAGIKSLHEPTGVLARSSRC--------------VKRWHR 60

  Fly   286 KS--------VPNQLVAITYSQISAMYFARNEYKNSHLWSGLAMRFLKGYANPRT--------II 334
            :|        :|:|......:..|....|         |..:|.. |.|.::.:|        :|
Zfish    61 RSWHRCASLQMPSQKSHSDTTDFSRWTLA---------WGAVAFS-LFGGSDEKTEEQKLEDELI 115

  Fly   335 DVLRQAAKACVVKRDFARANLLICQAVRRAREYFGPTHQKYGDALLDYGFFLL-----------N 388
            .:|:: ||..::..:...|:..:.:|||.|       ||.:.:..:.|.:.|:           |
Zfish   116 LLLKK-AKYSMMIGELDAADGFLHRAVRLA-------HQMHNNDAIIYTYSLMANLAFVRGQLDN 172

  Fly   389 VDSVF-------------QSVNIYKEALAVRRGIFGNMNFHVAIAHEDLSYAYYVHEYSTGDFSC 440
            .:.:|             |..|...|.......|:...|               .:|.:...|..
Zfish   173 AEKLFKAAMSFMLSGGTPQDDNALIEMSLKLASIYATQN---------------KNELAEHGFQF 222

  Fly   441 AQDHVDKAVNIMQHLVPSNHLMLASAKRVKALLLEEIALDKMADGIDEEDLLLQSEELHNFALLL 505
            ..|.::..::..:.|.|.:   |:..:|....||..::||..|..:......:.:...:..||.:
Zfish   223 CTDSLEAKMDKQKDLPPES---LSDEERKDTRLLLGLSLDARARYLAANHRFIGACRDYRHALQI 284

  Fly   506 SLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKKAIKIKSELLGHFDYEVGLSIGHLASLY 570
            ..:..||.:.||.....:|..:.....:.:||....|||::: .:..||.:..|  .:|::|.:.
Zfish   285 CQEEQGESHPQTLVLMSDLATVLDLQGKHDEALVYVKKAVEL-GQAAGHPEQHV--LLGNMAGIL 346

  Fly   571 NYQMKKYRDAEQLYMRSIDIS 591
            .:. .::.::.:||..::.::
Zfish   347 MHN-GEFEESAKLYQEALALA 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142
		TPR_12	478..547	CDD:290160	15/68 (22%)
		TPR_12	516..590	CDD:290160	15/73 (21%)
		TPR_10	517..553	CDD:290111	7/35 (20%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	559..590	CDD:276809	5/30 (17%)
		TPR repeat	603..628	CDD:276809
ttc19	NP_001333173.1	TPR 1	154..187		4/32 (13%)
		TPR 2	297..330		6/33 (18%)
		TPR 3	336..369		5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900