DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pat1 and nphp3

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001189370.1	Gene:	nphp3 / 562601	ZFINID:	ZDB-GENE-091204-117	Length:	1303	Species:	Danio rerio

Alignment Length:	589	Identity:	122/589 - (20%)
Similarity:	215/589 - (36%)	Gaps:	147/589 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 TEFSSLYTYDSESTNA----DSISDFNDEFSADIGSIVGLPHRRATQEE--------LDAINDSG 195
            |.||:.:|.|......    |::|.:.      :|..|.|....:.||:        |...:.:|
Zfish   701 THFSTSWTLDRTLQQCVMCQDTVSLYR------LGLKVALDSLNSDQEKHIMKELLCLVCASHNG 759

  Fly   196 LEELSAVELQVIDLGLRLGSFLSEAGWMQESITVL------------ACLNVRLKDLPTHKHWLQ 248
            :.|...:||..   .|...:.:|....::..:.:.            ||..|..:.|...|....
Zfish   760 ISESEVLELFP---DLTFPALISMLHNLERLLIITYACGLIRFQHSQACEGVNQEFLDGDKCRGS 821

  Fly   249 FRLDCL----QRLLYAESAHCNFKEAEKTYAELMGLNKWLNKSVPNQLVAITYSQISA--MYFAR 307
            :|..|:    |:|   |.....::.|::.        .||.:...::    :..|:|.  ::.::
Zfish   822 YREKCIRFFSQQL---EQDRVTWRVADEL--------PWLLQQQEDR----SKLQMSLLNLFVSQ 871

  Fly   308 NEYKNSHLWSGLA-MRFL-KGYANPRT-IIDVLRQAAKACVVKRDFAR-ANL------------L 356
            |.||..|....|| .:|: |...:..| ..|.|::..|.|..::..:| |||            |
Zfish   872 NLYKRGHFSELLAYWQFVGKDKCSMATEYFDALKEFEKTCESEQSMSRLANLYETLGRFLKDLGL 936

  Fly   357 ICQAV---RRAREY----FGPTHQKYGDALLDYGFFLLNVDSVFQSVNIYKEALAVRRGIFGNMN 414
            :.|||   :|:.|.    ..|.|.....:|.......::......:..:||:|:.:....:|..:
Zfish   937 LSQAVAPLQRSLEIRETALDPDHPSVAQSLHQLAGVYVHWRKFGNAEQLYKQAMEICENAYGPEH 1001

  Fly   415 FHVAIAHEDLSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLV-PSNHLMLASAKRVKALLLEEIA 478
            ..||...:.||..|    .....:..|:....::|.|.|... ...|:...:..:.:||.|||:.
Zfish  1002 STVARELDSLSLLY----QKQNKYEQAEKLRKRSVKIRQKTARQKGHMYGFALLKRRALQLEELT 1062

  Fly   479 LDKMADGIDEEDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKK 543
            |.|     |..|                          .||....||.||...|..:.|:....:
Zfish  1063 LGK-----DSTD--------------------------CAKTLNELGVLYYLQNNLDAAKLFLTR 1096

  Fly   544 AIKIKSELLGHFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSIDISLRLFGNSYSGLEYDYLG 608
            :::::..:||....:...|:.:||:|:: :.|:|..||:||.|::||..|.....:..|.|....
Zfish  1097 SLEMRQRVLGPDHPDCAQSLNNLAALHS-ERKEYESAEELYERALDIRKRALAPDHPSLAYTLKH 1160

  Fly   609 LCHVYETLHNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIEVDYSIEEVKAKYFSMCASKKSA 673
            |..:|:.....||                        :.|..|:..   |::.|.|.      ..
Zfish  1161 LAMLYKRRGKLEK------------------------AVPLYELAL---EIREKSFG------PK 1192

  Fly   674 HPSV 677
            ||||
Zfish  1193 HPSV 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142
		TPR_12	478..547	CDD:290160	12/68 (18%)
		TPR_12	516..590	CDD:290160	21/73 (29%)
		TPR_10	517..553	CDD:290111	8/35 (23%)
		TPR repeat	518..546	CDD:276809	8/27 (30%)
		TPR repeat	559..590	CDD:276809	11/30 (37%)
		TPR repeat	603..628	CDD:276809	5/24 (21%)
nphp3	NP_001189370.1	Uso1_p115_C	90..180	CDD:282695
		OmpH	<101..>186	CDD:281871
		TPR 1	449..482
		TPR 2	802..840		10/40 (25%)
		TPR_12	920..995	CDD:290160	15/74 (20%)
		TPR_10	920..960	CDD:290111	10/39 (26%)
		TPR 3	921..954		9/32 (28%)
		TPR repeat	921..949	CDD:276809	8/27 (30%)
		TPR_12	959..1037	CDD:290160	14/81 (17%)
		TPR_10	962..1001	CDD:290111	5/38 (13%)
		TPR repeat	962..992	CDD:276809	4/29 (14%)
		TPR 4	963..996		4/32 (13%)
		TPR repeat	1005..1057	CDD:276809	10/55 (18%)
		TPR 5	1005..1038		8/36 (22%)
		TPR_12	1069..1145	CDD:290160	24/102 (24%)
		TPR_10	1071..1111	CDD:290111	10/39 (26%)
		TPR 6	1071..1104		8/32 (25%)
		TPR repeat	1071..1099	CDD:276809	8/27 (30%)
		TPR_12	1109..1187	CDD:290160	23/105 (22%)
		TPR_10	1113..1152	CDD:290111	14/39 (36%)
		TPR 7	1113..1146		13/33 (39%)
		TPR repeat	1113..1141	CDD:276809	11/28 (39%)
		TPR_12	1151..1229	CDD:290160	15/79 (19%)
		TPR_10	1154..1194	CDD:290111	11/72 (15%)
		TPR 8	1155..1188		8/59 (14%)
		TPR repeat	1155..1183	CDD:276809	7/54 (13%)
		TPR_12	1193..1271	CDD:290160	4/4 (100%)
		TPR_10	1196..1237	CDD:290111	1/1 (100%)
		TPR repeat	1196..1234	CDD:276809	1/1 (100%)
		TPR 9	1197..1230		122/589 (21%)
		TPR 10	1239..1272
		TPR repeat	1239..1267	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1303
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810