DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pat1 and TTC19

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_060245.3	Gene:	TTC19 / 54902	HGNCID:	26006	Length:	380	Species:	Homo sapiens

Alignment Length:	307	Identity:	57/307 - (18%)
Similarity:	131/307 - (42%)	Gaps:	51/307 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 IIDVLRQAAKACVVKRDFARANLLICQAVRRAREYFGPTHQKYG-----DALLDYGFF---LLNV 389
            ||.:|:: ||..::|.:...|.|::..|:|.|.:    |..|..     |.:.:..|.   |.|.
Human    96 IIQLLKR-AKLSIMKDEPEEAELILHDALRLAYQ----TDNKKAITYTYDLMANLAFIRGQLENA 155

  Fly   390 DSVFQSVNIYKEALAVRRGIFGNMNFHVAIAHEDLSYAYYVHEYSTGDF----SCAQDHVDKAVN 450
            :.:|::...|.....:::.  .|....:::....:..|....|::...:    |..::.:::...
Human   156 EQLFKATMSYLLGGGMKQE--DNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKE 218

  Fly   451 IMQHLV-----PSNHLMLASAKRVKALLLEEIALDKMADGIDEEDLLLQSEELHNFALLLSLQVF 510
            :.:.::     .:.||:|.            :.||..|..:.......|::.::..||.:|.::.
Human   219 LAEDIMSVEEKANTHLLLG------------MCLDACARYLLFSKQPSQAQRMYEKALQISEEIQ 271

  Fly   511 GEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKKAIKIKSELLGHFDY-EVGLSIGHLASLYNYQM 574
            ||.:.||.....:|........||:||....::|    |:|....:: |:.:.:.:||::..::
Human   272 GERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRA----SDLARQINHPELHMVLSNLAAVLMHR- 331

  Fly   575 KKYRDAEQLYMRSIDISLRLFGNSYSGLEYDYLGLCHVYETLHNFEK 621
            ::|..|:::|..::         ..:.|:.|.:.:.|:.|.|....|
Human   332 ERYTQAKEIYQEAL---------KQAKLKKDEISVQHIREELAELSK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142
		TPR_12	478..547	CDD:290160	17/68 (25%)
		TPR_12	516..590	CDD:290160	16/74 (22%)
		TPR_10	517..553	CDD:290111	9/35 (26%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	559..590	CDD:276809	5/30 (17%)
		TPR repeat	603..628	CDD:276809	5/19 (26%)
TTC19	NP_060245.3	TPR 1	136..169		6/32 (19%)
		TPR 2	179..212		3/32 (9%)
		TPR_12	233..311	CDD:290160	22/93 (24%)
		TPR 3	237..270		7/44 (16%)
		TPR_12	275..349	CDD:290160	16/87 (18%)
		TPR repeat	278..308	CDD:276809	8/33 (24%)
		TPR 4	279..312		8/36 (22%)
		TPR 5	318..351		5/42 (12%)
		TPR repeat	318..346	CDD:276809	5/37 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900