DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pat1 and Nphp3

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001178811.1	Gene:	Nphp3 / 363126	RGDID:	1563856	Length:	1325	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	127/595 - (21%)
Similarity:	216/595 - (36%)	Gaps:	150/595 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ENYVSRYEVVAGHEEEELESSMDTVEDRSTEFSSLYTYDSESTNADSISDFNDEFS-ADIGSIVG 177
            ::.:|.|.:|..|..|.:.|  |..::..|:...|........:...:.:...|.| |.:.|||.
  Rat   738 QDTMSLYRLVLHHVRESMPS--DKEKEWMTQILCLINVSHNGVSESELMELYPEMSWASLTSIVH 800

  Fly   178 LPH------------RRATQEELDAINDSGLEE---LSAVELQVIDLGLRLGSFLSEAGWMQESI 227
            ..|            |....:..:.:..:.:|:   :|:...::||.      |.|:..  |:.:
  Rat   801 SLHKMHLLTYSCGLLRFQHLQAWETVRQAYMEDPALVSSYRQKLIDY------FTSQLS--QDRV 857

  Fly   228 TVLACLNVRLKDLPTHKHWL-------QFRLDCLQRLLYAESAHCNFKEAEKTYAELMGLNKWLN 285
            |..:.     .:||    ||       |....||..|..:::.   :|...  :|||  |:.|
  Rat   858 TWRSA-----DELP----WLFQQQGSKQKLHSCLLNLFVSQNL---YKRGH--FAEL--LSYW-- 904

  Fly   286 KSVPNQLVAITYSQISAMYF-ARNEYKNSHLWSGLAMRFLKGYANPRTIIDVLRQAAKACVVKRD 349
                 |.|....|.::..|| :..:|:|           .:|..|...:.|:.....:
  Rat   905 -----QFVGKDKSAMATEYFESLKQYEN-----------CEGEENMLCLADLYETLGR------- 946

  Fly   350 FARANLLICQAV---RRAREY----FGPTHQKYGDALLDYGFFLLNVDSVFQSVNIYKEALAVRR 407
            |.:...|:.|||   :|:.|.    ..|.|.:...:|.......:.......:..:||:||.:..
  Rat   947 FLKDLGLLSQAVVPLQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFSDAEQLYKQALEISE 1011

  Fly   408 GIFGNMNFHVAIAHEDLSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLVPSNHLMLASAKRVKAL 472
            ..:|..:.|.|...|.|:..|    :....:..|:....|:|.|.|           .|.|.|..
  Rat  1012 NAYGADHPHAARELEALATLY----HKQNKYEQAERFRKKSVIIRQ-----------QATRRKGS 1061

  Fly   473 LLEEIALDKMADGIDEEDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEA 537
            |.....|.:.|         ||.|||          ..|:...:.|:....||.||...|..|.|
  Rat  1062 LYGFALLRRRA---------LQLEEL----------TLGKDKPENARTLNELGVLYYLQNNLETA 1107

  Fly   538 ERMHKKAIKIKSELLGHFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSIDISLRLFGNSYSGL 602
            |:..|::::::..:||....:...|:.:||:|.| :.|:|..||:||.|::||..|.....:..|
  Rat  1108 EQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN-ERKQYARAEELYERALDIRRRALAPDHPSL 1171

  Fly   603 EYDYLGLCHVYETLHNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIEVDYSIEEVKAKYFSMC 667
            .|....|..:|:.....:|                        :.|..|:   ..|::.|.|.
  Rat  1172 AYTVKHLAILYKKTGRVDK------------------------AVPLYEL---AVEIRQKSFG-- 1207

  Fly   668 ASKKSAHPSV 677
                ..||||
  Rat  1208 ----PKHPSV 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142
		TPR_12	478..547	CDD:290160	18/68 (26%)
		TPR_12	516..590	CDD:290160	24/73 (33%)
		TPR_10	517..553	CDD:290111	10/35 (29%)
		TPR repeat	518..546	CDD:276809	10/27 (37%)
		TPR repeat	559..590	CDD:276809	12/30 (40%)
		TPR repeat	603..628	CDD:276809	4/24 (17%)
Nphp3	NP_001178811.1	Prefoldin	112..207	CDD:298833
		OmpH	<120..>202	CDD:281871
		P-loop_NTPase	502..>556	CDD:304359
		TPR_12	937..1012	CDD:290160	15/81 (19%)
		TPR_10	937..978	CDD:290111	10/47 (21%)
		TPR repeat	938..966	CDD:276809	7/34 (21%)
		TPR_12	976..1054	CDD:290160	17/92 (18%)
		TPR repeat	976..1009	CDD:276809	6/32 (19%)
		TPR_10	979..1020	CDD:290111	6/40 (15%)
		TPR repeat	1022..1074	CDD:276809	15/75 (20%)
		TPR_12	1085..1162	CDD:290160	26/77 (34%)
		TPR_10	1088..1128	CDD:290111	12/39 (31%)
		TPR repeat	1088..1116	CDD:276809	10/27 (37%)
		TPR_12	1126..1204	CDD:290160	23/105 (22%)
		TPR repeat	1129..1164	CDD:276809	15/35 (43%)
		TPR_10	1130..1169	CDD:290111	15/39 (38%)
		TPR_12	1168..1246	CDD:290160	14/79 (18%)
		TPR repeat	1172..1200	CDD:276809	6/54 (11%)
		TPR_10	1177..1211	CDD:290111	8/66 (12%)
		TPR_12	1210..1288	CDD:290160	4/4 (100%)
		TPR_10	1213..1254	CDD:290111	1/1 (100%)
		TPR repeat	1213..1243	CDD:276809	1/1 (100%)
		TPR repeat	1256..1284	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810