DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pat1 and Klc2

DIOPT Version :9

Sequence 1:NP_001259286.1 Gene:Pat1 / 31593 FlyBaseID:FBgn0029878 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_001356290.1 Gene:Klc2 / 16594 MGIID:107953 Length:636 Species:Mus musculus


Alignment Length:433 Identity:105/433 - (24%)
Similarity:168/433 - (38%) Gaps:99/433 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 QEELDAINDSGLEELSAVELQVI-DLGLRLGSFLSEAGWMQESITVLACLNVRLKDLPTHKHWLQ 248
            :..|:||      ||...|.||| .|...||:..||   .|:       |..:::.|.....||:
Mouse    62 RRSLEAI------ELGLGEAQVILALSSHLGAVESE---KQK-------LRAQVRRLVQENQWLR 110

  Fly   249 FRL-DCLQRLLYAESAHCNFKEAEKTYAELMGLNKWLNKSVPNQLVA-ITYSQISAMYFARNEYK 311
            ..| ...|:|..:|.|....:|.::....:..:.|....:.||:... :....:..::  .||.:
Mouse   111 EELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDSLDDLF--PNEDE 173

  Fly   312 NSHLWS---GLAMRFLKGYANP---RTIIDVLRQAAKACVVKRDFARANLLICQAVRRAREYFGP 370
            .|...|   |.......||..|   ||:.:::.|.|.    :..:..|..|..||:....:..|.
Mouse   174 QSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYAS----QGRYEVAVPLCKQALEDLEKTSGH 234

  Fly   371 THQKYGDALLDYGFFLLNVDS-VFQSVNIYKEALAVRRGIFGNMNFHVAIAHEDLSYAYYVHEYS 434
            .|.....        :||:.: |::..|.||:|                 ||. |:.|..:.|.:
Mouse   235 DHPDVAT--------MLNILALVYRDQNKYKDA-----------------AHL-LNDALAIREKT 273

  Fly   435 TGDFSCAQDHVDKAVNIMQHLVPSNHLMLASAKRVKALLLEEIALDKMADGIDEEDLLLQSEELH 499
            .|     :||...|..:       |:|.:...||.|                     ..::|.|.
Mouse   274 LG-----KDHPAVAATL-------NNLAVLYGKRGK---------------------YKEAEPLC 305

  Fly   500 NFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKKAIKIKSELLGHFDYEVGLSIG 564
            ..||.:..:|.|:.:...||...||..|.|...:.||.|..:::|::|.:..||..|..|..:..
Mouse   306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370

  Fly   565 HLASLYNYQMKKYRDAEQLYMRSIDISLRL----FGNSYSGLE 603
            :|||.| .:..||:|||.||.   :|..|.    ||:..:.||
Mouse   371 NLASCY-LKQGKYQDAETLYK---EILTRAHEKEFGSVNARLE 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pat1NP_001259286.1 DnaQ_like_exo <53..110 CDD:299142
TPR_12 478..547 CDD:290160 16/68 (24%)
TPR_12 516..590 CDD:290160 26/73 (36%)
TPR_10 517..553 CDD:290111 11/35 (31%)
TPR repeat 518..546 CDD:276809 10/27 (37%)
TPR repeat 559..590 CDD:276809 12/30 (40%)
TPR repeat 603..628 CDD:276809 1/1 (100%)
Klc2NP_001356290.1 SMC_prok_B <9..>139 CDD:274008 25/92 (27%)
TPR_12 197..272 CDD:315987 21/104 (20%)
TPR repeat 199..226 CDD:276809 8/30 (27%)
TPR_12 238..314 CDD:315987 25/134 (19%)
TPR repeat 240..268 CDD:276809 11/53 (21%)
TPR_12 281..354 CDD:315987 22/100 (22%)
TPR repeat 282..310 CDD:276809 9/55 (16%)
TPR_12 322..396 CDD:315987 27/77 (35%)
TPR repeat 323..353 CDD:276809 10/29 (34%)
TPR repeat 366..393 CDD:276809 11/30 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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