DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pat1 and appbp2

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_002933870.1	Gene:	appbp2 / 100487715	XenbaseID:	XB-GENE-951373	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	656	Identity:	257/656 - (39%)
Similarity:	364/656 - (55%)	Gaps:	109/656 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PKTLYDLSLQALIGSMNTKIPALDRISR----LAELPRNLLIDVYEMMSQQESLKDTLLEELAQL 78
            |:|||:.::.|::          |..||    :..||.|:..|||..:.||..|.. |..|..:|
Frog    10 PETLYNTAISAVV----------DNYSRARRDIRSLPENIQFDVYYKLYQQGRLCQ-LGSEFCEL 63

  Fly    79 EVFARLVRYPFARSQLLRIMASLMASQKMLAKRLSENYVSRYEVVAGHEEEELESSMDTVEDRST 143
            ||||:::|....|..|.....:||                                     |...
Frog    64 EVFAKVLRALDKRHLLHHCFQALM-------------------------------------DHGV 91

  Fly   144 EFSSLYTYDSESTNADSISDFNDEFSADIGSIVGLPHRRATQEELDAINDSGLEELSAVELQVID 208
            :.:|:..|               .||.....|              |.:|:.::|      :.|.
Frog    92 KVASVLAY---------------SFSRRCSYI--------------AESDAHVKE------KAIQ 121

  Fly   209 LGLRLGSFLSEAGWMQESITVL-ACLNV-RLKDLPTHKHWLQFR-LDCLQRLLYAESAHCNFKEA 270
            :|..||.|||:|||..::..|. :||.: ..::...|    .|| ::|..|||:..:.:|.:...
Frog   122 IGFVLGGFLSDAGWYSDAEKVFQSCLQLCGFQNEMLH----CFRAVECCVRLLHVRNGNCKYHLG 182

  Fly   271 EKTYA-------ELMGLNKWLNKSVPNQLVAITYSQISAMYFARNEYKNSHLWSGLAMRFLKGYA 328
            |:|:.       :|:...::.||       |..:.::.|:.||::.|..::.|...||:.:....
Frog   183 EETFKLAQTYMDKLVKHRQYANK-------AALFGELCALLFAKSHYDEAYKWCIEAMKEITSGL 240

  Fly   329 NPRTIIDVLRQAAKACVVKRDFARANLLICQAVRRAREYFGPTHQKYGDALLDYGFFLLNVDSVF 393
            ..:.|:||||||:|||||||:|.:|..||..||..|||.|||.|.||.||||||||:|||||::.
Frog   241 PVKVIVDVLRQASKACVVKREFKKAEQLIKHAVYLARENFGPKHPKYSDALLDYGFYLLNVDNIC 305

  Fly   394 QSVNIYKEALAVRRGIFGNMNFHVAIAHEDLSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLVPS 458
            |||.||:.||.:|:.:||..|.|||.|||||:|:.|||:||:|.|..|..|.::|:.|:.|::|.
Frog   306 QSVAIYQTALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIEIITHILPE 370

  Fly   459 NHLMLASAKRVKALLLEEIALDKMADGIDEEDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGN 523
            :||:|||:||||||:|||||:| ..:...|:.||.::.:||..:|.|:.:.|||.||||||||||
Frog   371 DHLLLASSKRVKALILEEIAID-CHNKETEQKLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGN 434

  Fly   524 LGRLYQTMNRFEEAERMHKKAIKIKSELLGHFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSI 588
            ||||||:|.:|:|||.||.|||:||.:|||..||||.||:|||||||||.|.:|.:||:||:|||
Frog   435 LGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMSQYENAEKLYLRSI 499

  Fly   589 DISLRLFGNSYSGLEYDYLGLCHVYETLHNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIEVD 653
            .|..:|||..||||||||.||..:|.::.|:||..:|.:.|.||..||.:..:...:........
Frog   500 AIGKKLFGEGYSGLEYDYRGLIKLYNSVGNYEKVFEYHNILANWNRLRDRQFSVTDALEDVNTSP 564

  Fly   654 YSIEEV 659
            .|.|||
Frog   565 LSTEEV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142	18/56 (32%)
		TPR_12	478..547	CDD:290160	38/68 (56%)
		TPR_12	516..590	CDD:290160	53/73 (73%)
		TPR_10	517..553	CDD:290111	26/35 (74%)
		TPR repeat	518..546	CDD:276809	21/27 (78%)
		TPR repeat	559..590	CDD:276809	21/30 (70%)
		TPR repeat	603..628	CDD:276809	11/24 (46%)
appbp2	XP_002933870.1	TPR_12	290..363	CDD:315987	42/72 (58%)
appbp2	XP_002933870.1	TPR_12	427..504	CDD:315987	54/76 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2376
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31378
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1850
OMA	1	1.010	-	-		QHG49921
OrthoDB	1	1.010	-	-		D263289at33208
OrthoFinder	1	1.000	-	-		FOG0008171
OrthoInspector	1	1.000	-	-		oto103973
Panther	1	1.100	-	-	LDO	PTHR46575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080